Oxytocin and Its Receptors Are Synthesized in the Rat Vasculature

Produced and released by the heart, oxytocin (OT) acts on its cardiac receptors to decrease the cardiac rate and force of contraction. We hypothesized that it might also be produced in the vasculature and regulate vascular tone. Consequently, we prepared acid extracts of the pulmonary artery and ven...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-05, Vol.97 (11), p.6207-6211
Hauptverfasser:	Jankowski, Marek, Wang, Donghao, Hajjar, Fadi, Mukaddam-Daher, Suhayla, McCann, Samuel M., Gutkowska, Jolanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Aorta - drug effects Aorta - metabolism Atrial Natriuretic Factor - biosynthesis Atrial Natriuretic Factor - genetics Biological Sciences Blood vessels Blood Vessels - metabolism Cardiovascular system Cava Chromatography, High Pressure Liquid Complementary DNA Coronary vessels diethylstilbestrol Diethylstilbestrol - pharmacology Dogs - metabolism Estrogens - physiology Female Gene Expression Regulation - drug effects Heart Hormones Messenger RNA Organ Specificity Oxytocin - biosynthesis Oxytocin - genetics Polymerase Chain Reaction Pulmonary Artery - metabolism Pulmonary Veins - metabolism Rats Rats - metabolism Rats, Sprague-Dawley Receptors Receptors, Oxytocin - biosynthesis Receptors, Oxytocin - genetics Reverse transcriptase polymerase chain reaction RNA RNA, Messenger - biosynthesis Rodents Sheep - metabolism Species Specificity Vena Cava, Superior - drug effects Vena Cava, Superior - metabolism
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