Oxytocin and Its Receptors Are Synthesized in the Rat Vasculature
Produced and released by the heart, oxytocin (OT) acts on its cardiac receptors to decrease the cardiac rate and force of contraction. We hypothesized that it might also be produced in the vasculature and regulate vascular tone. Consequently, we prepared acid extracts of the pulmonary artery and ven...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2000-05, Vol.97 (11), p.6207-6211 |
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| creator | Jankowski, Marek Wang, Donghao Hajjar, Fadi Mukaddam-Daher, Suhayla McCann, Samuel M. Gutkowska, Jolanta |
| description | Produced and released by the heart, oxytocin (OT) acts on its cardiac receptors to decrease the cardiac rate and force of contraction. We hypothesized that it might also be produced in the vasculature and regulate vascular tone. Consequently, we prepared acid extracts of the pulmonary artery and vena cava of male rats. OT concentrations in dog and sheep aortae were equivalent to those of rat aorta (2745 ± 180 pg/mg protein), indicating that it is present in the vasculature of several mammalian species. Reverse-phase HPLC of aorta and vena cava extracts revealed a single peak corresponding to the amidated OT nonapeptide. Reverse-transcribed PCR confirmed OT synthesis in these tissues. Using the selective OT receptor ligand compound VI, we detected a high number of OT-binding sites in the rat vena cava and aorta. Furthermore, OT receptor (OTR) mRNA was found in the vena cava, pulmonary vein, and pulmonary artery with lower levels in the aorta, suggesting vessel-specific OTR distribution. The abundance of OTR mRNA in the vena cava and pulmonary vein was associated with high atrial natriuretic peptide mRNA. In addition, we have demonstrated that diethylstilbestrol treatment of immature female rats increased OT significantly in the vena cava but not in the aorta and augmented OTR mRNA in both the aorta (4-fold) and vena cava (2-fold), implying regulation by estrogen. Altogether, these data suggest that the vasculature contains an intrinsic OT system, which may be involved in the regulation of vascular tone as well as vascular regrowth and remodeling. |
| doi_str_mv | 10.1073/pnas.110137497 |
| format | Article |
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We hypothesized that it might also be produced in the vasculature and regulate vascular tone. Consequently, we prepared acid extracts of the pulmonary artery and vena cava of male rats. OT concentrations in dog and sheep aortae were equivalent to those of rat aorta (2745 ± 180 pg/mg protein), indicating that it is present in the vasculature of several mammalian species. Reverse-phase HPLC of aorta and vena cava extracts revealed a single peak corresponding to the amidated OT nonapeptide. Reverse-transcribed PCR confirmed OT synthesis in these tissues. Using the selective OT receptor ligand compound VI, we detected a high number of OT-binding sites in the rat vena cava and aorta. Furthermore, OT receptor (OTR) mRNA was found in the vena cava, pulmonary vein, and pulmonary artery with lower levels in the aorta, suggesting vessel-specific OTR distribution. The abundance of OTR mRNA in the vena cava and pulmonary vein was associated with high atrial natriuretic peptide mRNA. In addition, we have demonstrated that diethylstilbestrol treatment of immature female rats increased OT significantly in the vena cava but not in the aorta and augmented OTR mRNA in both the aorta (4-fold) and vena cava (2-fold), implying regulation by estrogen. Altogether, these data suggest that the vasculature contains an intrinsic OT system, which may be involved in the regulation of vascular tone as well as vascular regrowth and remodeling.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.110137497</identifier><identifier>PMID: 10811917</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Aorta ; Aorta - drug effects ; Aorta - metabolism ; Atrial Natriuretic Factor - biosynthesis ; Atrial Natriuretic Factor - genetics ; Biological Sciences ; Blood vessels ; Blood Vessels - metabolism ; Cardiovascular system ; Cava ; Chromatography, High Pressure Liquid ; Complementary DNA ; Coronary vessels ; diethylstilbestrol ; Diethylstilbestrol - pharmacology ; Dogs - metabolism ; Estrogens - physiology ; Female ; Gene Expression Regulation - drug effects ; Heart ; Hormones ; Messenger RNA ; Organ Specificity ; Oxytocin - biosynthesis ; Oxytocin - genetics ; Polymerase Chain Reaction ; Pulmonary Artery - metabolism ; Pulmonary Veins - metabolism ; Rats ; Rats - metabolism ; Rats, Sprague-Dawley ; Receptors ; Receptors, Oxytocin - biosynthesis ; Receptors, Oxytocin - genetics ; Reverse transcriptase polymerase chain reaction ; RNA ; RNA, Messenger - biosynthesis ; Rodents ; Sheep - metabolism ; Species Specificity ; Vena Cava, Superior - drug effects ; Vena Cava, Superior - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (11), p.6207-6211</ispartof><rights>Copyright 1993-2000 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences May 23, 2000</rights><rights>Copyright © The National Academy of Sciences 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-d3ce88f0348d240653d1c3afc722fe47044e59ceb3da090a889663c26e866e8a3</citedby><cites>FETCH-LOGICAL-c583t-d3ce88f0348d240653d1c3afc722fe47044e59ceb3da090a889663c26e866e8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/97/11.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/122606$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/122606$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10811917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jankowski, Marek</creatorcontrib><creatorcontrib>Wang, Donghao</creatorcontrib><creatorcontrib>Hajjar, Fadi</creatorcontrib><creatorcontrib>Mukaddam-Daher, Suhayla</creatorcontrib><creatorcontrib>McCann, Samuel M.</creatorcontrib><creatorcontrib>Gutkowska, Jolanta</creatorcontrib><title>Oxytocin and Its Receptors Are Synthesized in the Rat Vasculature</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Produced and released by the heart, oxytocin (OT) acts on its cardiac receptors to decrease the cardiac rate and force of contraction. We hypothesized that it might also be produced in the vasculature and regulate vascular tone. Consequently, we prepared acid extracts of the pulmonary artery and vena cava of male rats. OT concentrations in dog and sheep aortae were equivalent to those of rat aorta (2745 ± 180 pg/mg protein), indicating that it is present in the vasculature of several mammalian species. Reverse-phase HPLC of aorta and vena cava extracts revealed a single peak corresponding to the amidated OT nonapeptide. Reverse-transcribed PCR confirmed OT synthesis in these tissues. Using the selective OT receptor ligand compound VI, we detected a high number of OT-binding sites in the rat vena cava and aorta. Furthermore, OT receptor (OTR) mRNA was found in the vena cava, pulmonary vein, and pulmonary artery with lower levels in the aorta, suggesting vessel-specific OTR distribution. The abundance of OTR mRNA in the vena cava and pulmonary vein was associated with high atrial natriuretic peptide mRNA. In addition, we have demonstrated that diethylstilbestrol treatment of immature female rats increased OT significantly in the vena cava but not in the aorta and augmented OTR mRNA in both the aorta (4-fold) and vena cava (2-fold), implying regulation by estrogen. Altogether, these data suggest that the vasculature contains an intrinsic OT system, which may be involved in the regulation of vascular tone as well as vascular regrowth and remodeling.</description><subject>Animals</subject><subject>Aorta</subject><subject>Aorta - drug effects</subject><subject>Aorta - metabolism</subject><subject>Atrial Natriuretic Factor - biosynthesis</subject><subject>Atrial Natriuretic Factor - genetics</subject><subject>Biological Sciences</subject><subject>Blood vessels</subject><subject>Blood Vessels - metabolism</subject><subject>Cardiovascular system</subject><subject>Cava</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Complementary DNA</subject><subject>Coronary vessels</subject><subject>diethylstilbestrol</subject><subject>Diethylstilbestrol - pharmacology</subject><subject>Dogs - metabolism</subject><subject>Estrogens - physiology</subject><subject>Female</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Heart</subject><subject>Hormones</subject><subject>Messenger RNA</subject><subject>Organ Specificity</subject><subject>Oxytocin - biosynthesis</subject><subject>Oxytocin - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Pulmonary Artery - metabolism</subject><subject>Pulmonary Veins - metabolism</subject><subject>Rats</subject><subject>Rats - metabolism</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors</subject><subject>Receptors, Oxytocin - biosynthesis</subject><subject>Receptors, Oxytocin - genetics</subject><subject>Reverse transcriptase polymerase chain reaction</subject><subject>RNA</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Rodents</subject><subject>Sheep - metabolism</subject><subject>Species Specificity</subject><subject>Vena Cava, Superior - drug effects</subject><subject>Vena Cava, Superior - metabolism</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctr3DAQxkVJaTZprrkUiukhPXk7elgPyGUJfQQCgaTNVSjyOPHitTeSXLL96yuzabrtIQcxgvl9o0_zEXJMYU5B8U_r3sU5pUC5Eka9IjMKhpZSGNgjMwCmSi2Y2CcHMS4BwFQa3pB9CppSQ9WMLC4fN2nwbV-4vi7OUyyu0OM6DSEWi4DF9aZP9xjbX1gXGcr34sql4sZFP3YujQHfkteN6yIePdVD8uPL5-9n38qLy6_nZ4uL0leap7LmHrVugAtdMwGy4jX13DVeMdagUCAEVsbjLa8dGHBaGym5ZxK1zMfxQ3K6nbseb1dYe-xTcJ1dh3blwsYOrrX_dvr23t4NPy3V2UCWnzzJw_AwYkx21UaPXed6HMZoqapYVUmawQ__gcthDH3-mmXTmivBIUPzLeTDEGPA5tkHBTsFY6dg7HMwWfB-1_0Ovk1iB5iEf9pG5RlWMpiAjy8Cthm7LuFjyuS7LbmMOce_TzEmQfLft26qUA</recordid><startdate>20000523</startdate><enddate>20000523</enddate><creator>Jankowski, Marek</creator><creator>Wang, Donghao</creator><creator>Hajjar, Fadi</creator><creator>Mukaddam-Daher, Suhayla</creator><creator>McCann, Samuel M.</creator><creator>Gutkowska, Jolanta</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20000523</creationdate><title>Oxytocin and Its Receptors Are Synthesized in the Rat Vasculature</title><author>Jankowski, Marek ; 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We hypothesized that it might also be produced in the vasculature and regulate vascular tone. Consequently, we prepared acid extracts of the pulmonary artery and vena cava of male rats. OT concentrations in dog and sheep aortae were equivalent to those of rat aorta (2745 ± 180 pg/mg protein), indicating that it is present in the vasculature of several mammalian species. Reverse-phase HPLC of aorta and vena cava extracts revealed a single peak corresponding to the amidated OT nonapeptide. Reverse-transcribed PCR confirmed OT synthesis in these tissues. Using the selective OT receptor ligand compound VI, we detected a high number of OT-binding sites in the rat vena cava and aorta. Furthermore, OT receptor (OTR) mRNA was found in the vena cava, pulmonary vein, and pulmonary artery with lower levels in the aorta, suggesting vessel-specific OTR distribution. The abundance of OTR mRNA in the vena cava and pulmonary vein was associated with high atrial natriuretic peptide mRNA. In addition, we have demonstrated that diethylstilbestrol treatment of immature female rats increased OT significantly in the vena cava but not in the aorta and augmented OTR mRNA in both the aorta (4-fold) and vena cava (2-fold), implying regulation by estrogen. Altogether, these data suggest that the vasculature contains an intrinsic OT system, which may be involved in the regulation of vascular tone as well as vascular regrowth and remodeling.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>10811917</pmid><doi>10.1073/pnas.110137497</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Aorta Aorta - drug effects Aorta - metabolism Atrial Natriuretic Factor - biosynthesis Atrial Natriuretic Factor - genetics Biological Sciences Blood vessels Blood Vessels - metabolism Cardiovascular system Cava Chromatography, High Pressure Liquid Complementary DNA Coronary vessels diethylstilbestrol Diethylstilbestrol - pharmacology Dogs - metabolism Estrogens - physiology Female Gene Expression Regulation - drug effects Heart Hormones Messenger RNA Organ Specificity Oxytocin - biosynthesis Oxytocin - genetics Polymerase Chain Reaction Pulmonary Artery - metabolism Pulmonary Veins - metabolism Rats Rats - metabolism Rats, Sprague-Dawley Receptors Receptors, Oxytocin - biosynthesis Receptors, Oxytocin - genetics Reverse transcriptase polymerase chain reaction RNA RNA, Messenger - biosynthesis Rodents Sheep - metabolism Species Specificity Vena Cava, Superior - drug effects Vena Cava, Superior - metabolism |
| title | Oxytocin and Its Receptors Are Synthesized in the Rat Vasculature |
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