Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle

To explore the possible role of monocyte chemotactic protein (MCP-1) in inflammatory diseases of the heart, we expressed the murine MCP-1(JE) gene under the control of the alpha-cardiac myosin heavy chain promoter to attempt to target MCP-1 expression to the adult heart muscle. The five lines of tra...

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Veröffentlicht in:	The American journal of pathology 1998-01, Vol.152 (1), p.101-111
Hauptverfasser:	Kolattukudy, PE, Quach, T, Bergese, S, Breckenridge, S, Hensley, J, Altschuld, R, Gordillo, G, Klenotic, S, Orosz, C, Parker-Thornburg, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Cytokines - metabolism Echocardiography Gene Expression - physiology Gene Targeting Heart Heart - physiology Medical sciences Mice Mice, Transgenic - genetics Myocarditis - genetics Myocarditis - metabolism Myocarditis - pathology Myocarditis. Cardiomyopathies Myocardium - metabolism Myocardium - pathology RNA - metabolism Tissue Distribution
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