Expression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage

Matrix metalloproteinases (MMPs) are expressed in osteoarthritic (OA) cartilage and are thought to be involved in the degradation of cartilage extracellular matrix (ECM). Among these proteinases, MMP-2 (gelatinase A) demonstrates a wide range of substrate specificity against the ECM present in carti...

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Veröffentlicht in:	The American journal of pathology 1997-07, Vol.151 (1), p.245-256
Hauptverfasser:	Imai, K, Ohta, S, Matsumoto, T, Fujimoto, N, Sato, H, Seiki, M, Okada, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Cartilage, Articular - enzymology Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Membrane - enzymology Cells, Cultured Collagenases - biosynthesis Collagenases - genetics Diseases of the osteoarticular system Enzyme Activation - drug effects Enzyme Precursors - biosynthesis Enzyme Precursors - metabolism Gelatinases - biosynthesis Gelatinases - metabolism Gene Expression Regulation, Enzymologic - drug effects Humans Interleukin-1 - pharmacology Matrix Metalloproteinase 1 Medical sciences Metalloendopeptidases - biosynthesis Metalloendopeptidases - metabolism Middle Aged Osteoarthritis Osteoarthritis - enzymology Osteoarthritis - genetics Osteoarthritis - pathology RNA, Messenger - biosynthesis Tumor Necrosis Factor-alpha - pharmacology
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