Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis

Transforming growth factor (TGF)-beta 1 may potentiate wound healing and fibrosis by stimulating fibroblast collagen deposition. TGF-beta 1 is implicated in the pathogenesis of pulmonary fibrosis, but the role of TGF-beta 2 and TGF-beta 3 remains unclear. We examined their effects on lung fibroblast...

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Veröffentlicht in:	The American journal of pathology 1997-03, Vol.150 (3), p.981-991
Hauptverfasser:	Coker, RK, Laurent, GJ, Shahzeidi, S, Lympany, PA, du Bois, RM, Jeffery, PK, McAnulty, RJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin Carrier Proteins - genetics Carrier Proteins - pharmacology Cells, Cultured Fibroblasts - metabolism Fibrosis - chemically induced Gene Expression Gene Expression Regulation In Situ Hybridization Intracellular Signaling Peptides and Proteins Isomerism Latent TGF-beta Binding Proteins Lung - drug effects Lung - metabolism Lung - pathology Mice Procollagen - biosynthesis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Pulmonary Fibrosis - physiopathology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - pharmacology
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