Dose dependent and divergent effects of superoxide anion on cell death, proliferation, and migration of activated human hepatic stellate cells

Background and aim: Activated myofibroblast-like cells, originating from hepatic stellate cells (HSC/MFs) or other cellular sources, play a key profibrogenic role in chronic liver diseases (CLDs) that, as suggested by studies in animal models or rat HSC/MFs, may be modulated by reactive oxygen inter...

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Veröffentlicht in:	Gut 2006-01, Vol.55 (1), p.90-97
Hauptverfasser:	Novo, E, Marra, F, Zamara, E, Valfrè di Bonzo, L, Caligiuri, A, Cannito, S, Antonaci, C, Colombatto, S, Pinzani, M, Parola, M
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxynonenal activated hepatic stellate cells in myofibroblast-like phenotype activated human hepatic stellate cells Apoptosis Apoptosis - drug effects Biological and medical sciences Cell Death - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured chronic liver diseases CLDs Collagen Type I - metabolism Cytotoxicity Dose-Response Relationship, Drug ECL ECM enhanced chemiluminescence Enzymes ERK Experiments extracellular matrix extracellular regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Gastroenterology. Liver. Pancreas. Abdomen Growth factors H2O2 hepatic stellate cells Hepatitis Hepatocytes - cytology Hepatocytes - drug effects HNE HSC HSC/MFs Humans hydrogen peroxide Hydrogen Peroxide - pharmacology hypoxanthine/xanthine oxidase system generating superoxide anion induction of cell death L-NAME lactate dehydrogenase LDH Liver Liver - cytology Liver - metabolism Liver diseases liver fibrosis Medical sciences MFs myofibroblast migration myofibroblast-like cells nitric oxide Nω-nitro-L-arginine methyl ester O2 Oxidative stress PDGF phosphatidyl inositol 3-kinase PI-3 K platelet derived growth factor reactive oxygen intermediates Rodents ROI serum free Iscove’s medium SFI medium Signal transduction Signal Transduction - physiology SOD superoxide anion superoxide dismutase Superoxides - metabolism Superoxides - pharmacology TGF-β1 TIMP tissue inhibitor of metalloproteinases transforming growth factor β1 X/XO
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