Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum
Background: Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects. Objectives: To assess resistin expression in synovial ti...
Gespeichert in:
| Veröffentlicht in: | Annals of the rheumatic diseases 2007-04, Vol.66 (4), p.458-463 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 463 |
|---|---|
| container_issue | 4 |
| container_start_page | 458 |
| container_title | Annals of the rheumatic diseases |
| container_volume | 66 |
| creator | Šenolt, L Housa, D Vernerová, Z Jirásek, T Svobodová, R Veigl, D Anderlová, K Müller-Ladner, U Pavelka, K Haluzík, M |
| description | Background: Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects. Objectives: To assess resistin expression in synovial tissues, serum and synovial fluid from patients with rheumatoid arthritis, osteoarthritis and spondylarthropathies (SpA), and to study its relationship with inflammatory status and rheumatoid arthritis disease activity. Methods: Resistin expression and localisation in synovial tissue was determined by immunohistochemistry and confocal microscopy. Serum and synovial fluid resistin, leptin, interleukin (IL)1β, IL6, IL8, tumour necrosis factor α, and monocyte chemoattractant protein-1 levels were measured. The clinical activity of patients with rheumatoid arthritis was assessed according to the 28 joint count Disease Activity Score (DAS28). Results: Resistin was detected in the synovium in both rheumatoid arthritis and osteoarthritis. Staining in the sublining layer was more intensive in patients with rheumatoid arthritis compared with those with osteoarthritis. In rheumatoid arthritis, macrophages (CD68), B lymphocytes (CD20) and plasma cells (CD138) but not T lymphocytes (CD3) showed colocalisation with resistin. Synovial fluid resistin was higher in patients with rheumatoid arthritis than in those with SpA or osteoarthritis (both p |
| doi_str_mv | 10.1136/ard.2006.054734 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1856051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4008406781</sourcerecordid><originalsourceid>FETCH-LOGICAL-b619t-88b0a6be7faaf32a90c2782b61913d1a0ba43918f0325967cfdb7fb6d220ff513</originalsourceid><addsrcrecordid>eNqFkd1rFDEUxYModlt99k0GxD6Is71JZvLxIsjiJ0VBtPoW7swkbtb5qMlMsf-9GWfpqi-FQLg5vxxOcgh5RGFNKRdnGJo1AxBrKAvJiztkRQuhcgYC7pIVAPC80EIekeMYd2kERdV9ckQlFKAFXZH3n2z0cfR9llbY2qnDcfBNhmHcBj_6mMXrfrjy2GZpiJN9fjhw7TSTfZNFG6buAbnnsI324X4_IV9ev_q8eZuff3zzbvPyPK8E1WOuVAUoKisdouMMNdRMKjaLlDcUocKCa6occFam7LVrKukq0TAGzpWUn5AXi-_lVHW2qW0_BmzNZfAdhmszoDf_Kr3fmu_DlaGqFPDH4HRvEIafk42j6Xysbdtib4cpGglMaEbhVpABU5oxkcAn_4G7YQp9-gVDpZSqBKplos4Wqg5DjMG6m8wUzFynSXWauU6z1JluPP77qQd-318Cnu4BjDW2LmBf-3jgVKmYFrNRvnCpa_vrRsfwwwjJZWk-XGzM1w1cfJNaGZb4ZwtfdbtbU_4GhiPE7g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777850197</pqid></control><display><type>article</type><title>Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Šenolt, L ; Housa, D ; Vernerová, Z ; Jirásek, T ; Svobodová, R ; Veigl, D ; Anderlová, K ; Müller-Ladner, U ; Pavelka, K ; Haluzík, M</creator><creatorcontrib>Šenolt, L ; Housa, D ; Vernerová, Z ; Jirásek, T ; Svobodová, R ; Veigl, D ; Anderlová, K ; Müller-Ladner, U ; Pavelka, K ; Haluzík, M</creatorcontrib><description>Background: Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects. Objectives: To assess resistin expression in synovial tissues, serum and synovial fluid from patients with rheumatoid arthritis, osteoarthritis and spondylarthropathies (SpA), and to study its relationship with inflammatory status and rheumatoid arthritis disease activity. Methods: Resistin expression and localisation in synovial tissue was determined by immunohistochemistry and confocal microscopy. Serum and synovial fluid resistin, leptin, interleukin (IL)1β, IL6, IL8, tumour necrosis factor α, and monocyte chemoattractant protein-1 levels were measured. The clinical activity of patients with rheumatoid arthritis was assessed according to the 28 joint count Disease Activity Score (DAS28). Results: Resistin was detected in the synovium in both rheumatoid arthritis and osteoarthritis. Staining in the sublining layer was more intensive in patients with rheumatoid arthritis compared with those with osteoarthritis. In rheumatoid arthritis, macrophages (CD68), B lymphocytes (CD20) and plasma cells (CD138) but not T lymphocytes (CD3) showed colocalisation with resistin. Synovial fluid resistin was higher in patients with rheumatoid arthritis than in those with SpA or osteoarthritis (both p<0.001). In patients with rheumatoid arthritis and SpA, serum resistin levels were higher than those with osteoarthritis (p<0.01). Increased serum resistin in patients with rheumatoid arthritis correlated with both CRP (r = 0.53, p<0.02), and DAS28 (r = 0.44, p<0.05), but not with selected (adipo) cytokines. Conclusion: The upregulated resistin at local sites of inflammation and the link between serum resistin, inflammation and disease activity suggest a role for resistin in the pathogenesis of rheumatoid arthritis.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2006.054734</identifier><identifier>PMID: 17040961</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - metabolism ; Biological and medical sciences ; Biomarkers - blood ; Body mass index ; Cloning ; Cytokines ; DAS28 ; Diabetes ; Disease ; Disease Activity Score 28 ; disease-modifying antirheumatic drugs ; Diseases of the osteoarticular system ; DMARDs ; Extended Report ; Female ; Fluids ; Gene expression ; Humans ; Hypotheses ; Immunoenzyme Techniques ; Immunoglobulins ; Inflammation ; Inflammation Mediators - analysis ; Inflammatory diseases ; Inflammatory joint diseases ; Insulin ; Insulin resistance ; Joint surgery ; Lasers ; Male ; Medical sciences ; Microscopy, Confocal ; Middle Aged ; Molecular weight ; Obesity ; Osteoarthritis, Knee - blood ; Osteoarthritis, Knee - metabolism ; Patients ; Resistin - analysis ; Resistin - blood ; Rheumatism ; Rheumatoid arthritis ; Severity of Illness Index ; SpA ; Spondylarthropathies - blood ; Spondylarthropathies - metabolism ; spondylarthropathy ; Surgery ; Synovial Fluid - chemistry ; Synovial Membrane - chemistry ; TNF ; Tumor necrosis factor-TNF ; tumour necrosis factor</subject><ispartof>Annals of the rheumatic diseases, 2007-04, Vol.66 (4), p.458-463</ispartof><rights>Copyright 2007 by Annals of the Rheumatic Diseases</rights><rights>2007 INIST-CNRS</rights><rights>Copyright: 2007 Copyright 2007 by Annals of the Rheumatic Diseases</rights><rights>Copyright © 2007 BMJ Publishing Group and European League Against Rheumatism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b619t-88b0a6be7faaf32a90c2782b61913d1a0ba43918f0325967cfdb7fb6d220ff513</citedby><cites>FETCH-LOGICAL-b619t-88b0a6be7faaf32a90c2782b61913d1a0ba43918f0325967cfdb7fb6d220ff513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/66/4/458.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/66/4/458.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,723,776,780,881,3182,23551,27903,27904,53769,53771,77346,77377</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18582964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17040961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Šenolt, L</creatorcontrib><creatorcontrib>Housa, D</creatorcontrib><creatorcontrib>Vernerová, Z</creatorcontrib><creatorcontrib>Jirásek, T</creatorcontrib><creatorcontrib>Svobodová, R</creatorcontrib><creatorcontrib>Veigl, D</creatorcontrib><creatorcontrib>Anderlová, K</creatorcontrib><creatorcontrib>Müller-Ladner, U</creatorcontrib><creatorcontrib>Pavelka, K</creatorcontrib><creatorcontrib>Haluzík, M</creatorcontrib><title>Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Background: Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects. Objectives: To assess resistin expression in synovial tissues, serum and synovial fluid from patients with rheumatoid arthritis, osteoarthritis and spondylarthropathies (SpA), and to study its relationship with inflammatory status and rheumatoid arthritis disease activity. Methods: Resistin expression and localisation in synovial tissue was determined by immunohistochemistry and confocal microscopy. Serum and synovial fluid resistin, leptin, interleukin (IL)1β, IL6, IL8, tumour necrosis factor α, and monocyte chemoattractant protein-1 levels were measured. The clinical activity of patients with rheumatoid arthritis was assessed according to the 28 joint count Disease Activity Score (DAS28). Results: Resistin was detected in the synovium in both rheumatoid arthritis and osteoarthritis. Staining in the sublining layer was more intensive in patients with rheumatoid arthritis compared with those with osteoarthritis. In rheumatoid arthritis, macrophages (CD68), B lymphocytes (CD20) and plasma cells (CD138) but not T lymphocytes (CD3) showed colocalisation with resistin. Synovial fluid resistin was higher in patients with rheumatoid arthritis than in those with SpA or osteoarthritis (both p<0.001). In patients with rheumatoid arthritis and SpA, serum resistin levels were higher than those with osteoarthritis (p<0.01). Increased serum resistin in patients with rheumatoid arthritis correlated with both CRP (r = 0.53, p<0.02), and DAS28 (r = 0.44, p<0.05), but not with selected (adipo) cytokines. Conclusion: The upregulated resistin at local sites of inflammation and the link between serum resistin, inflammation and disease activity suggest a role for resistin in the pathogenesis of rheumatoid arthritis.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Body mass index</subject><subject>Cloning</subject><subject>Cytokines</subject><subject>DAS28</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Disease Activity Score 28</subject><subject>disease-modifying antirheumatic drugs</subject><subject>Diseases of the osteoarticular system</subject><subject>DMARDs</subject><subject>Extended Report</subject><subject>Female</subject><subject>Fluids</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Immunoenzyme Techniques</subject><subject>Immunoglobulins</subject><subject>Inflammation</subject><subject>Inflammation Mediators - analysis</subject><subject>Inflammatory diseases</subject><subject>Inflammatory joint diseases</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Joint surgery</subject><subject>Lasers</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Confocal</subject><subject>Middle Aged</subject><subject>Molecular weight</subject><subject>Obesity</subject><subject>Osteoarthritis, Knee - blood</subject><subject>Osteoarthritis, Knee - metabolism</subject><subject>Patients</subject><subject>Resistin - analysis</subject><subject>Resistin - blood</subject><subject>Rheumatism</subject><subject>Rheumatoid arthritis</subject><subject>Severity of Illness Index</subject><subject>SpA</subject><subject>Spondylarthropathies - blood</subject><subject>Spondylarthropathies - metabolism</subject><subject>spondylarthropathy</subject><subject>Surgery</subject><subject>Synovial Fluid - chemistry</subject><subject>Synovial Membrane - chemistry</subject><subject>TNF</subject><subject>Tumor necrosis factor-TNF</subject><subject>tumour necrosis factor</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkd1rFDEUxYModlt99k0GxD6Is71JZvLxIsjiJ0VBtPoW7swkbtb5qMlMsf-9GWfpqi-FQLg5vxxOcgh5RGFNKRdnGJo1AxBrKAvJiztkRQuhcgYC7pIVAPC80EIekeMYd2kERdV9ckQlFKAFXZH3n2z0cfR9llbY2qnDcfBNhmHcBj_6mMXrfrjy2GZpiJN9fjhw7TSTfZNFG6buAbnnsI324X4_IV9ev_q8eZuff3zzbvPyPK8E1WOuVAUoKisdouMMNdRMKjaLlDcUocKCa6occFam7LVrKukq0TAGzpWUn5AXi-_lVHW2qW0_BmzNZfAdhmszoDf_Kr3fmu_DlaGqFPDH4HRvEIafk42j6Xysbdtib4cpGglMaEbhVpABU5oxkcAn_4G7YQp9-gVDpZSqBKplos4Wqg5DjMG6m8wUzFynSXWauU6z1JluPP77qQd-318Cnu4BjDW2LmBf-3jgVKmYFrNRvnCpa_vrRsfwwwjJZWk-XGzM1w1cfJNaGZb4ZwtfdbtbU_4GhiPE7g</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Šenolt, L</creator><creator>Housa, D</creator><creator>Vernerová, Z</creator><creator>Jirásek, T</creator><creator>Svobodová, R</creator><creator>Veigl, D</creator><creator>Anderlová, K</creator><creator>Müller-Ladner, U</creator><creator>Pavelka, K</creator><creator>Haluzík, M</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ</general><general>Elsevier Limited</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070401</creationdate><title>Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum</title><author>Šenolt, L ; Housa, D ; Vernerová, Z ; Jirásek, T ; Svobodová, R ; Veigl, D ; Anderlová, K ; Müller-Ladner, U ; Pavelka, K ; Haluzík, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b619t-88b0a6be7faaf32a90c2782b61913d1a0ba43918f0325967cfdb7fb6d220ff513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Body mass index</topic><topic>Cloning</topic><topic>Cytokines</topic><topic>DAS28</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Disease Activity Score 28</topic><topic>disease-modifying antirheumatic drugs</topic><topic>Diseases of the osteoarticular system</topic><topic>DMARDs</topic><topic>Extended Report</topic><topic>Female</topic><topic>Fluids</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Immunoenzyme Techniques</topic><topic>Immunoglobulins</topic><topic>Inflammation</topic><topic>Inflammation Mediators - analysis</topic><topic>Inflammatory diseases</topic><topic>Inflammatory joint diseases</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Joint surgery</topic><topic>Lasers</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Confocal</topic><topic>Middle Aged</topic><topic>Molecular weight</topic><topic>Obesity</topic><topic>Osteoarthritis, Knee - blood</topic><topic>Osteoarthritis, Knee - metabolism</topic><topic>Patients</topic><topic>Resistin - analysis</topic><topic>Resistin - blood</topic><topic>Rheumatism</topic><topic>Rheumatoid arthritis</topic><topic>Severity of Illness Index</topic><topic>SpA</topic><topic>Spondylarthropathies - blood</topic><topic>Spondylarthropathies - metabolism</topic><topic>spondylarthropathy</topic><topic>Surgery</topic><topic>Synovial Fluid - chemistry</topic><topic>Synovial Membrane - chemistry</topic><topic>TNF</topic><topic>Tumor necrosis factor-TNF</topic><topic>tumour necrosis factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Šenolt, L</creatorcontrib><creatorcontrib>Housa, D</creatorcontrib><creatorcontrib>Vernerová, Z</creatorcontrib><creatorcontrib>Jirásek, T</creatorcontrib><creatorcontrib>Svobodová, R</creatorcontrib><creatorcontrib>Veigl, D</creatorcontrib><creatorcontrib>Anderlová, K</creatorcontrib><creatorcontrib>Müller-Ladner, U</creatorcontrib><creatorcontrib>Pavelka, K</creatorcontrib><creatorcontrib>Haluzík, M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Šenolt, L</au><au>Housa, D</au><au>Vernerová, Z</au><au>Jirásek, T</au><au>Svobodová, R</au><au>Veigl, D</au><au>Anderlová, K</au><au>Müller-Ladner, U</au><au>Pavelka, K</au><au>Haluzík, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>66</volume><issue>4</issue><spage>458</spage><epage>463</epage><pages>458-463</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Background: Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects. Objectives: To assess resistin expression in synovial tissues, serum and synovial fluid from patients with rheumatoid arthritis, osteoarthritis and spondylarthropathies (SpA), and to study its relationship with inflammatory status and rheumatoid arthritis disease activity. Methods: Resistin expression and localisation in synovial tissue was determined by immunohistochemistry and confocal microscopy. Serum and synovial fluid resistin, leptin, interleukin (IL)1β, IL6, IL8, tumour necrosis factor α, and monocyte chemoattractant protein-1 levels were measured. The clinical activity of patients with rheumatoid arthritis was assessed according to the 28 joint count Disease Activity Score (DAS28). Results: Resistin was detected in the synovium in both rheumatoid arthritis and osteoarthritis. Staining in the sublining layer was more intensive in patients with rheumatoid arthritis compared with those with osteoarthritis. In rheumatoid arthritis, macrophages (CD68), B lymphocytes (CD20) and plasma cells (CD138) but not T lymphocytes (CD3) showed colocalisation with resistin. Synovial fluid resistin was higher in patients with rheumatoid arthritis than in those with SpA or osteoarthritis (both p<0.001). In patients with rheumatoid arthritis and SpA, serum resistin levels were higher than those with osteoarthritis (p<0.01). Increased serum resistin in patients with rheumatoid arthritis correlated with both CRP (r = 0.53, p<0.02), and DAS28 (r = 0.44, p<0.05), but not with selected (adipo) cytokines. Conclusion: The upregulated resistin at local sites of inflammation and the link between serum resistin, inflammation and disease activity suggest a role for resistin in the pathogenesis of rheumatoid arthritis.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>17040961</pmid><doi>10.1136/ard.2006.054734</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4967 |
| ispartof | Annals of the rheumatic diseases, 2007-04, Vol.66 (4), p.458-463 |
| issn | 0003-4967 1468-2060 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1856051 |
| source | MEDLINE; BMJ Journals - NESLi2; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - metabolism Biological and medical sciences Biomarkers - blood Body mass index Cloning Cytokines DAS28 Diabetes Disease Disease Activity Score 28 disease-modifying antirheumatic drugs Diseases of the osteoarticular system DMARDs Extended Report Female Fluids Gene expression Humans Hypotheses Immunoenzyme Techniques Immunoglobulins Inflammation Inflammation Mediators - analysis Inflammatory diseases Inflammatory joint diseases Insulin Insulin resistance Joint surgery Lasers Male Medical sciences Microscopy, Confocal Middle Aged Molecular weight Obesity Osteoarthritis, Knee - blood Osteoarthritis, Knee - metabolism Patients Resistin - analysis Resistin - blood Rheumatism Rheumatoid arthritis Severity of Illness Index SpA Spondylarthropathies - blood Spondylarthropathies - metabolism spondylarthropathy Surgery Synovial Fluid - chemistry Synovial Membrane - chemistry TNF Tumor necrosis factor-TNF tumour necrosis factor |
| title | Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T06%3A31%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resistin%20in%20rheumatoid%20arthritis%20synovial%20tissue,%20synovial%20fluid%20and%20serum&rft.jtitle=Annals%20of%20the%20rheumatic%20diseases&rft.au=%C5%A0enolt,%20L&rft.date=2007-04-01&rft.volume=66&rft.issue=4&rft.spage=458&rft.epage=463&rft.pages=458-463&rft.issn=0003-4967&rft.eissn=1468-2060&rft.coden=ARDIAO&rft_id=info:doi/10.1136/ard.2006.054734&rft_dat=%3Cproquest_pubme%3E4008406781%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1777850197&rft_id=info:pmid/17040961&rfr_iscdi=true |