Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression

The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome. PTEN acts as a plasma-membrane lipid-phosphatase antagonizing the phosphoinositide 3-kinase/AKT cell survival pathway. However, PTEN is also...

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Veröffentlicht in:	Cell 2007-01, Vol.128 (1), p.141-156
Hauptverfasser:	Trotman, Lloyd C., Wang, Xinjiang, Alimonti, Andrea, Chen, Zhenbang, Teruya-Feldstein, Julie, Yang, Haijuan, Pavletich, Nikola P., Carver, Brett S., Cordon-Cardo, Carlos, Erdjument-Bromage, Hediye, Tempst, Paul, Chi, Sung-Gil, Kim, Hyo-Jong, Misteli, Tom, Jiang, Xuejun, Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Amino Acid Sequence Animals Cell Nucleus - metabolism Colonic Neoplasms - pathology Endosomal Sorting Complexes Required for Transport Glutamine - genetics Hamartoma Syndrome, Multiple - pathology Humans Lysine - genetics Mice Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - metabolism Mutation - genetics Nedd4 Ubiquitin Protein Ligases Neoplasm Staging Polyps - pathology Protein Structure, Secondary Protein Transport PTEN Phosphohydrolase - chemistry PTEN Phosphohydrolase - metabolism Tumor Suppressor Proteins - metabolism Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism
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