Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

Polycomb-repressive complex 2 (PRC2)-mediated histone methylation plays an important role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we show that S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A (DZNep) induces efficient apoptotic cell death in...

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Veröffentlicht in:	Genes & development 2007-05, Vol.21 (9), p.1050-1063
Hauptverfasser:	Tan, Jing, Yang, Xiaojing, Zhuang, Li, Jiang, Xia, Chen, Wei, Lee, Puay Leng, Karuturi, R K Murthy, Tan, Patrick Boon Ooi, Liu, Edison T, Yu, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosylhomocysteinase - antagonists & inhibitors Apoptosis - drug effects Apoptosis - genetics Base Sequence Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Chromatin Assembly and Disassembly Chromatin Immunoprecipitation Enzyme Inhibitors - pharmacology Epigenesis, Genetic Female Histones - metabolism Humans Methylation Polycomb-Group Proteins Promoter Regions, Genetic Repressor Proteins - antagonists & inhibitors Repressor Proteins - genetics Repressor Proteins - metabolism Research Paper RNA Interference RNA Polymerase II - metabolism RNA, Small Interfering - genetics
Online-Zugang:	Volltext
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