Secretory phospholipase A2 IIA is up-regulated by TNF-α and IL-1α/β after transient focal cerebral ischemia in rat
Cerebral ischemia initiates an inflammatory response in the brain that is associated with induction of a variety of cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-1α/β (IL-1α/β) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spontaneous...
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| Veröffentlicht in: | Brain research 2007-02, Vol.1134 (1), p.199-205 |
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| creator | MURALIKRISHNA ADIBHATLA, Rao HATCHER, J. F |
| description | Cerebral ischemia initiates an inflammatory response in the brain that is associated with induction of a variety of cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-1α/β (IL-1α/β) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in significant increases in TNF-α and IL-1β levels. We have previously demonstrated up-regulation of secretory phospholipase A
2
IIA (sPLA
2
IIA) mRNA and protein expression, increased PLA
2
activity, and loss of phosphatidylcholine after 1 hr tMCAO and 24 hr reperfusion in SHR. Treatment with TNF-α antibody or IL-1 receptor antagonist significantly attenuated infarction volume, sPLA
2
IIA protein expression, PLA
2
activity and significantly restored phosphatidylcholine levels after tMCAO. This suggests that cytokine induction up-regulates sPLA
2
IIA protein expression, resulting in altered lipid metabolism that contributes to stroke injury. |
| doi_str_mv | 10.1016/j.brainres.2006.11.080 |
| format | Article |
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2
IIA (sPLA
2
IIA) mRNA and protein expression, increased PLA
2
activity, and loss of phosphatidylcholine after 1 hr tMCAO and 24 hr reperfusion in SHR. Treatment with TNF-α antibody or IL-1 receptor antagonist significantly attenuated infarction volume, sPLA
2
IIA protein expression, PLA
2
activity and significantly restored phosphatidylcholine levels after tMCAO. This suggests that cytokine induction up-regulates sPLA
2
IIA protein expression, resulting in altered lipid metabolism that contributes to stroke injury.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2006.11.080</identifier><identifier>PMID: 17204250</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier</publisher><subject>Biological and medical sciences ; Medical sciences ; Neurology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Brain research, 2007-02, Vol.1134 (1), p.199-205</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18488142$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>MURALIKRISHNA ADIBHATLA, Rao</creatorcontrib><creatorcontrib>HATCHER, J. F</creatorcontrib><title>Secretory phospholipase A2 IIA is up-regulated by TNF-α and IL-1α/β after transient focal cerebral ischemia in rat</title><title>Brain research</title><description>Cerebral ischemia initiates an inflammatory response in the brain that is associated with induction of a variety of cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-1α/β (IL-1α/β) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in significant increases in TNF-α and IL-1β levels. We have previously demonstrated up-regulation of secretory phospholipase A
2
IIA (sPLA
2
IIA) mRNA and protein expression, increased PLA
2
activity, and loss of phosphatidylcholine after 1 hr tMCAO and 24 hr reperfusion in SHR. Treatment with TNF-α antibody or IL-1 receptor antagonist significantly attenuated infarction volume, sPLA
2
IIA protein expression, PLA
2
activity and significantly restored phosphatidylcholine levels after tMCAO. This suggests that cytokine induction up-regulates sPLA
2
IIA protein expression, resulting in altered lipid metabolism that contributes to stroke injury.</description><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpVj9tKw0AQhhdRbK2-guyNl0n3mMONUIrVQNEL63WYJJN2S5qE3UToY9UH6TO5oAheDMPwMx_fT8g9ZyFnPJrvw8KCaS26UDAWhZyHLGEXZMqTWASRUOySTJlPgiRN5YTcOLf3p5QpuyYTHgumhGZTMr5jaXHo7JH2u875aUwPDulC0CxbUOPo2AcWt2MDA1a0ONLN6yo4nyi0Fc3WAT-f5ucvCvWAlg4WWmewHWjdldDQEi16z8Zjyh0eDFDTUgvDLbmqoXF497tn5GP1tFm-BOu352y5WAc913oIklpFKuIVVinWkFYRIEAppawxVkxrLRTHSKNggJwpQIU-LWImtH_TsZyRxx9uPxYHrEpv5m3y3poD2GPegcn_J63Z5dvuM-eJ1jyVHvDwCwDnC9W-X2ncH4AnKkm4EvIbCrl7sw</recordid><startdate>20070223</startdate><enddate>20070223</enddate><creator>MURALIKRISHNA ADIBHATLA, Rao</creator><creator>HATCHER, J. F</creator><general>Elsevier</general><scope>IQODW</scope><scope>5PM</scope></search><sort><creationdate>20070223</creationdate><title>Secretory phospholipase A2 IIA is up-regulated by TNF-α and IL-1α/β after transient focal cerebral ischemia in rat</title><author>MURALIKRISHNA ADIBHATLA, Rao ; HATCHER, J. F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p155t-8f46461ded9efa9d6aeaac333fe740555241e65e20ae104ae4ec33b7025461573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MURALIKRISHNA ADIBHATLA, Rao</creatorcontrib><creatorcontrib>HATCHER, J. F</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MURALIKRISHNA ADIBHATLA, Rao</au><au>HATCHER, J. F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secretory phospholipase A2 IIA is up-regulated by TNF-α and IL-1α/β after transient focal cerebral ischemia in rat</atitle><jtitle>Brain research</jtitle><date>2007-02-23</date><risdate>2007</risdate><volume>1134</volume><issue>1</issue><spage>199</spage><epage>205</epage><pages>199-205</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Cerebral ischemia initiates an inflammatory response in the brain that is associated with induction of a variety of cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-1α/β (IL-1α/β) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in significant increases in TNF-α and IL-1β levels. We have previously demonstrated up-regulation of secretory phospholipase A
2
IIA (sPLA
2
IIA) mRNA and protein expression, increased PLA
2
activity, and loss of phosphatidylcholine after 1 hr tMCAO and 24 hr reperfusion in SHR. Treatment with TNF-α antibody or IL-1 receptor antagonist significantly attenuated infarction volume, sPLA
2
IIA protein expression, PLA
2
activity and significantly restored phosphatidylcholine levels after tMCAO. This suggests that cytokine induction up-regulates sPLA
2
IIA protein expression, resulting in altered lipid metabolism that contributes to stroke injury.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier</pub><pmid>17204250</pmid><doi>10.1016/j.brainres.2006.11.080</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain research, 2007-02, Vol.1134 (1), p.199-205 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Medical sciences Neurology Vascular diseases and vascular malformations of the nervous system |
| title | Secretory phospholipase A2 IIA is up-regulated by TNF-α and IL-1α/β after transient focal cerebral ischemia in rat |
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