Inhibition of Notch Signaling Induces Neural Differentiation in Ewing Sarcoma

Cells from Ewing sarcoma exhibit cellular features and express markers, suggesting that the tumor is of neuroectodermal origin. Because Notch signaling regulates the differentiation of neuroectodermal cells during development, we examined the role of Notch signaling in Ewing sarcomas. We found that...

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Veröffentlicht in:	The American journal of pathology 2007-05, Vol.170 (5), p.1686-1694
Hauptverfasser:	Baliko, Frank, Bright, Tamara, Poon, Raymond, Cohen, Brenda, Egan, Sean E, Alman, Benjamin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases - antagonists & inhibitors Animals Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Bone Neoplasms - metabolism Cell Differentiation - physiology Cell Line, Tumor Cell Proliferation - drug effects Diseases of the osteoarticular system Enzyme Inhibitors - pharmacology Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Nude Neurons - cytology Neurons - drug effects Neurons - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Notch - drug effects Receptors, Notch - metabolism Regular Reverse Transcriptase Polymerase Chain Reaction Sarcoma, Ewing - metabolism Signal Transduction - drug effects Signal Transduction - physiology Transfection Tumors of striated muscle and skeleton
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