Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels
1. In vitro studies have been performed on human medium-sized muscular arteries (internal diameter 1-4 mm) in a classical organ bath and with human subcutaneous resistance arteries (internal diameter 103-626 microns) in a microvascular myograph. 2. Although the medium-sized muscular arteries showed...
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| Veröffentlicht in: | British journal of pharmacology 1989-07, Vol.97 (3), p.829-834 |
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| container_title | British journal of pharmacology |
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| creator | Nielsen, H Thom, S M Hughes, A D Martin, G N Mulvany, M J Sever, P S |
| description | 1. In vitro studies have been performed on human medium-sized muscular arteries (internal diameter 1-4 mm) in a classical organ bath and with human subcutaneous resistance arteries (internal diameter 103-626 microns) in a microvascular myograph. 2. Although the medium-sized muscular arteries showed no response to either of the alpha 2-agonists B-HT 933 or UK 14304 in concentrations up to 10 microM, the subcutaneous resistance arteries from all regions examined showed well-pronounced and concentration-dependent responses to B-HT 933, the pD2 (-log EC50) being 5.11 +/- 0.09. 3. In the resistance arteries the alpha 2-antagonist yohimbine caused a parallel shift to the right of the B-HT 933 concentration-response curve; the yohimbine pA2 for the B-HT 933 receptor was 7.86 +/- 0.12. 4. There was an inverse relationship between the maximum response to B-HT 933 and the calibre of the resistance vessels. 5. These results indicate the presence of a postjunctional alpha 2-adrenoceptor in human subcutaneous resistance arteries and not in medium sized muscular arteries. |
| doi_str_mv | 10.1111/j.1476-5381.1989.tb12022.x |
| format | Article |
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In vitro studies have been performed on human medium-sized muscular arteries (internal diameter 1-4 mm) in a classical organ bath and with human subcutaneous resistance arteries (internal diameter 103-626 microns) in a microvascular myograph. 2. Although the medium-sized muscular arteries showed no response to either of the alpha 2-agonists B-HT 933 or UK 14304 in concentrations up to 10 microM, the subcutaneous resistance arteries from all regions examined showed well-pronounced and concentration-dependent responses to B-HT 933, the pD2 (-log EC50) being 5.11 +/- 0.09. 3. In the resistance arteries the alpha 2-antagonist yohimbine caused a parallel shift to the right of the B-HT 933 concentration-response curve; the yohimbine pA2 for the B-HT 933 receptor was 7.86 +/- 0.12. 4. There was an inverse relationship between the maximum response to B-HT 933 and the calibre of the resistance vessels. 5. These results indicate the presence of a postjunctional alpha 2-adrenoceptor in human subcutaneous resistance arteries and not in medium sized muscular arteries.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1989.tb12022.x</identifier><identifier>PMID: 2547487</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antihypertensive Agents - pharmacology ; Arteries - drug effects ; Azepines - pharmacology ; Brimonidine Tartrate ; Doxazosin ; Female ; Humans ; In Vitro Techniques ; Male ; Middle Aged ; Norepinephrine - pharmacology ; Prazosin - analogs & derivatives ; Prazosin - pharmacology ; Quinoxalines - pharmacology ; Receptors, Adrenergic, alpha - physiology ; Regional Blood Flow - drug effects ; Skin - blood supply ; Vascular Resistance - drug effects ; Vasoconstriction ; Veins - drug effects ; Yohimbine - pharmacology</subject><ispartof>British journal of pharmacology, 1989-07, Vol.97 (3), p.829-834</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-371ecf259189ea5f3da30c3f0bbf8186f617f306e097e5bbfd73e183fa3b5dfa3</citedby><cites>FETCH-LOGICAL-c301t-371ecf259189ea5f3da30c3f0bbf8186f617f306e097e5bbfd73e183fa3b5dfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854570/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854570/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2547487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nielsen, H</creatorcontrib><creatorcontrib>Thom, S M</creatorcontrib><creatorcontrib>Hughes, A D</creatorcontrib><creatorcontrib>Martin, G N</creatorcontrib><creatorcontrib>Mulvany, M J</creatorcontrib><creatorcontrib>Sever, P S</creatorcontrib><title>Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1. In vitro studies have been performed on human medium-sized muscular arteries (internal diameter 1-4 mm) in a classical organ bath and with human subcutaneous resistance arteries (internal diameter 103-626 microns) in a microvascular myograph. 2. Although the medium-sized muscular arteries showed no response to either of the alpha 2-agonists B-HT 933 or UK 14304 in concentrations up to 10 microM, the subcutaneous resistance arteries from all regions examined showed well-pronounced and concentration-dependent responses to B-HT 933, the pD2 (-log EC50) being 5.11 +/- 0.09. 3. In the resistance arteries the alpha 2-antagonist yohimbine caused a parallel shift to the right of the B-HT 933 concentration-response curve; the yohimbine pA2 for the B-HT 933 receptor was 7.86 +/- 0.12. 4. There was an inverse relationship between the maximum response to B-HT 933 and the calibre of the resistance vessels. 5. These results indicate the presence of a postjunctional alpha 2-adrenoceptor in human subcutaneous resistance arteries and not in medium sized muscular arteries.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Arteries - drug effects</subject><subject>Azepines - pharmacology</subject><subject>Brimonidine Tartrate</subject><subject>Doxazosin</subject><subject>Female</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Norepinephrine - pharmacology</subject><subject>Prazosin - analogs & derivatives</subject><subject>Prazosin - pharmacology</subject><subject>Quinoxalines - pharmacology</subject><subject>Receptors, Adrenergic, alpha - physiology</subject><subject>Regional Blood Flow - drug effects</subject><subject>Skin - blood supply</subject><subject>Vascular Resistance - drug effects</subject><subject>Vasoconstriction</subject><subject>Veins - drug effects</subject><subject>Yohimbine - pharmacology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFv1DAQhS1EVbaFn4AUceCW4InjtcMBCVVQkCrRQzlbjjNmvcrGi8ep2n-Pl12twAdb4zfveayPsXfAGyjrw7aBTq1rKTQ00Ou-yQO0vG2bpxdsdZZeshXnXNUAWr9iV0Rbzouo5CW7bGWnOq1WzN9HyttldjnE2U6VnfYbW7W1HRPO0eE-x0TVDsdgM1aPlqKLM-UU_hqqMFebZWfnipbBLdnOGBeqElKgUrjiQCKc6DW78HYifHM6r9nPr18ebr7Vdz9uv998vqud4JBroQCdb2UPukcrvRit4E54Pgxeg177NSgv-Bp5r1CWy1EJBC28FYMcy37NPh1z98tQhnY452Qns09hZ9OziTaY_5U5bMyv-GhAy04qXgLenwJS_L0gZbML5HCajl8zqgcBXQel8eOx0aVIlNCfHwFuDpTM1hxQmAMKc6BkTpTMUzG__XfMs_WERfwBZn6UyA</recordid><startdate>198907</startdate><enddate>198907</enddate><creator>Nielsen, H</creator><creator>Thom, S M</creator><creator>Hughes, A D</creator><creator>Martin, G N</creator><creator>Mulvany, M J</creator><creator>Sever, P S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198907</creationdate><title>Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels</title><author>Nielsen, H ; Thom, S M ; Hughes, A D ; Martin, G N ; Mulvany, M J ; Sever, P S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-371ecf259189ea5f3da30c3f0bbf8186f617f306e097e5bbfd73e183fa3b5dfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Arteries - drug effects</topic><topic>Azepines - pharmacology</topic><topic>Brimonidine Tartrate</topic><topic>Doxazosin</topic><topic>Female</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Norepinephrine - pharmacology</topic><topic>Prazosin - analogs & derivatives</topic><topic>Prazosin - pharmacology</topic><topic>Quinoxalines - pharmacology</topic><topic>Receptors, Adrenergic, alpha - physiology</topic><topic>Regional Blood Flow - drug effects</topic><topic>Skin - blood supply</topic><topic>Vascular Resistance - drug effects</topic><topic>Vasoconstriction</topic><topic>Veins - drug effects</topic><topic>Yohimbine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nielsen, H</creatorcontrib><creatorcontrib>Thom, S M</creatorcontrib><creatorcontrib>Hughes, A D</creatorcontrib><creatorcontrib>Martin, G N</creatorcontrib><creatorcontrib>Mulvany, M J</creatorcontrib><creatorcontrib>Sever, P S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nielsen, H</au><au>Thom, S M</au><au>Hughes, A D</au><au>Martin, G N</au><au>Mulvany, M J</au><au>Sever, P S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1989-07</date><risdate>1989</risdate><volume>97</volume><issue>3</issue><spage>829</spage><epage>834</epage><pages>829-834</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>1. In vitro studies have been performed on human medium-sized muscular arteries (internal diameter 1-4 mm) in a classical organ bath and with human subcutaneous resistance arteries (internal diameter 103-626 microns) in a microvascular myograph. 2. Although the medium-sized muscular arteries showed no response to either of the alpha 2-agonists B-HT 933 or UK 14304 in concentrations up to 10 microM, the subcutaneous resistance arteries from all regions examined showed well-pronounced and concentration-dependent responses to B-HT 933, the pD2 (-log EC50) being 5.11 +/- 0.09. 3. In the resistance arteries the alpha 2-antagonist yohimbine caused a parallel shift to the right of the B-HT 933 concentration-response curve; the yohimbine pA2 for the B-HT 933 receptor was 7.86 +/- 0.12. 4. There was an inverse relationship between the maximum response to B-HT 933 and the calibre of the resistance vessels. 5. These results indicate the presence of a postjunctional alpha 2-adrenoceptor in human subcutaneous resistance arteries and not in medium sized muscular arteries.</abstract><cop>England</cop><pmid>2547487</pmid><doi>10.1111/j.1476-5381.1989.tb12022.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Antihypertensive Agents - pharmacology Arteries - drug effects Azepines - pharmacology Brimonidine Tartrate Doxazosin Female Humans In Vitro Techniques Male Middle Aged Norepinephrine - pharmacology Prazosin - analogs & derivatives Prazosin - pharmacology Quinoxalines - pharmacology Receptors, Adrenergic, alpha - physiology Regional Blood Flow - drug effects Skin - blood supply Vascular Resistance - drug effects Vasoconstriction Veins - drug effects Yohimbine - pharmacology |
| title | Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels |
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