Investigation of the vasoconstrictor action of subarachnoid haemoglobin in the pig cerebral circulation in vivo
1 Angiographic techniques have been used to study the influence of intracisternally injected haemoglobin on the diameters of the main intrathecal and representative extrathecal (ascending pharyngeal and facial) cranial arteries of the anaesthetized pig. 2 Intracisternal injection of haemoglobin caus...
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| Veröffentlicht in: | British journal of pharmacology 1989-07, Vol.97 (3), p.669-674 |
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| container_title | British journal of pharmacology |
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| creator | Byrne, J.V. Griffith, T.M. Edwards, D.H. Harrison, T.J. Johnston, K.R. |
| description | 1
Angiographic techniques have been used to study the influence of intracisternally injected haemoglobin on the diameters of the main intrathecal and representative extrathecal (ascending pharyngeal and facial) cranial arteries of the anaesthetized pig.
2
Intracisternal injection of haemoglobin caused concentration‐dependent decreases in the diameters of intra‐ but not extrathecal arteries suggesting that haemoglobin possesses local vasoconstrictor activity.
3
When infused into one ascending pharyngeal artery, acetylcholine (ACh) caused slight dilatation of the intrathecal arteries but no change in the diameters of the ascending pharyngeal and facial arteries. The dilator response induced by ACh in the intrathecal arteries was converted into frank constriction after intracisternal injection of haemoglobin (cerebrospinal fluid concentration approximately 2 × 10−5 m).
4
These findings are consistent with the hypothesis that subarachnoid haemoglobin can induce cerebral artery constriction by acting as an extraluminal ‘sink’ for intimally released endothelium‐derived relaxing factor (EDRF) and may be relevant to the pathogenesis of vasospasm after subarachnoid haemorrhage in man. |
| doi_str_mv | 10.1111/j.1476-5381.1989.tb12002.x |
| format | Article |
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Angiographic techniques have been used to study the influence of intracisternally injected haemoglobin on the diameters of the main intrathecal and representative extrathecal (ascending pharyngeal and facial) cranial arteries of the anaesthetized pig.
2
Intracisternal injection of haemoglobin caused concentration‐dependent decreases in the diameters of intra‐ but not extrathecal arteries suggesting that haemoglobin possesses local vasoconstrictor activity.
3
When infused into one ascending pharyngeal artery, acetylcholine (ACh) caused slight dilatation of the intrathecal arteries but no change in the diameters of the ascending pharyngeal and facial arteries. The dilator response induced by ACh in the intrathecal arteries was converted into frank constriction after intracisternal injection of haemoglobin (cerebrospinal fluid concentration approximately 2 × 10−5 m).
4
These findings are consistent with the hypothesis that subarachnoid haemoglobin can induce cerebral artery constriction by acting as an extraluminal ‘sink’ for intimally released endothelium‐derived relaxing factor (EDRF) and may be relevant to the pathogenesis of vasospasm after subarachnoid haemorrhage in man.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1989.tb12002.x</identifier><identifier>PMID: 2788022</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetylcholine - pharmacology ; Animals ; Arteries - anatomy & histology ; Arteries - drug effects ; Biological and medical sciences ; Biological Factors - pharmacology ; Cerebral Angiography ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebrovascular Circulation - drug effects ; Fundamental and applied biological sciences. Psychology ; Hemoglobins - cerebrospinal fluid ; Humans ; Nitric Oxide ; Subarachnoid Hemorrhage - physiopathology ; Subarachnoid Space - drug effects ; Swine ; Vasoconstriction - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>British journal of pharmacology, 1989-07, Vol.97 (3), p.669-674</ispartof><rights>1989 British Pharmacological Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4232-8b06774f9fd3a06c629bb9506d69d814d52b10da5e2c37d0b50d5b755b6b4023</citedby><cites>FETCH-LOGICAL-c4232-8b06774f9fd3a06c629bb9506d69d814d52b10da5e2c37d0b50d5b755b6b4023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854559/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854559/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19702598$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2788022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Byrne, J.V.</creatorcontrib><creatorcontrib>Griffith, T.M.</creatorcontrib><creatorcontrib>Edwards, D.H.</creatorcontrib><creatorcontrib>Harrison, T.J.</creatorcontrib><creatorcontrib>Johnston, K.R.</creatorcontrib><title>Investigation of the vasoconstrictor action of subarachnoid haemoglobin in the pig cerebral circulation in vivo</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Angiographic techniques have been used to study the influence of intracisternally injected haemoglobin on the diameters of the main intrathecal and representative extrathecal (ascending pharyngeal and facial) cranial arteries of the anaesthetized pig.
2
Intracisternal injection of haemoglobin caused concentration‐dependent decreases in the diameters of intra‐ but not extrathecal arteries suggesting that haemoglobin possesses local vasoconstrictor activity.
3
When infused into one ascending pharyngeal artery, acetylcholine (ACh) caused slight dilatation of the intrathecal arteries but no change in the diameters of the ascending pharyngeal and facial arteries. The dilator response induced by ACh in the intrathecal arteries was converted into frank constriction after intracisternal injection of haemoglobin (cerebrospinal fluid concentration approximately 2 × 10−5 m).
4
These findings are consistent with the hypothesis that subarachnoid haemoglobin can induce cerebral artery constriction by acting as an extraluminal ‘sink’ for intimally released endothelium‐derived relaxing factor (EDRF) and may be relevant to the pathogenesis of vasospasm after subarachnoid haemorrhage in man.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Arteries - anatomy & histology</subject><subject>Arteries - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biological Factors - pharmacology</subject><subject>Cerebral Angiography</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemoglobins - cerebrospinal fluid</subject><subject>Humans</subject><subject>Nitric Oxide</subject><subject>Subarachnoid Hemorrhage - physiopathology</subject><subject>Subarachnoid Space - drug effects</subject><subject>Swine</subject><subject>Vasoconstriction - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc1u1DAUhS1EVaaFR0CKkGCXYDtxbLNAhQpopUqw6N7yX2Y8ytiDnYT27et0wkCXtSzZ0nfuuVf3APAOwQrl83FboYa2JakZqhBnvBoUwhDi6u4FWB3RS7CCENISIcZegbOUthBmSMkpOMWUMYjxCoRrP9k0uLUcXPBF6IphY4tJpqCDT0N0egixkPovTaOSUeqND84UG2l3Yd0H5XyR71y5d-tC22hVlH2hXdRjf3DOfHJTeA1OOtkn-2Z5z8Ht92-3l1flzc8f15dfbkrd4BqXTMGW0qbjnaklbHWLuVKcwNa03DDUGIIVgkYSi3VNDVQEGqIoIapVDcT1Ofh8sN2PameNtn7IA4l9dDsZ70WQTjwl3m3EOkwCMdIQwrPBh8Ught9j3pDYuaRt30tvw5gE5QjnJbdZ-Okg1DGkFG13bIKgmNMSWzFHIuZIxJyWWNISd7n47f9jHkuXeDJ_v3CZtOy7KL126V8HTiEmnGXdxUH3x_X2_hkTiK-_rh6_9QMQabV6</recordid><startdate>198907</startdate><enddate>198907</enddate><creator>Byrne, J.V.</creator><creator>Griffith, T.M.</creator><creator>Edwards, D.H.</creator><creator>Harrison, T.J.</creator><creator>Johnston, K.R.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198907</creationdate><title>Investigation of the vasoconstrictor action of subarachnoid haemoglobin in the pig cerebral circulation in vivo</title><author>Byrne, J.V. ; Griffith, T.M. ; Edwards, D.H. ; Harrison, T.J. ; Johnston, K.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4232-8b06774f9fd3a06c629bb9506d69d814d52b10da5e2c37d0b50d5b755b6b4023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Arteries - anatomy & histology</topic><topic>Arteries - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biological Factors - pharmacology</topic><topic>Cerebral Angiography</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemoglobins - cerebrospinal fluid</topic><topic>Humans</topic><topic>Nitric Oxide</topic><topic>Subarachnoid Hemorrhage - physiopathology</topic><topic>Subarachnoid Space - drug effects</topic><topic>Swine</topic><topic>Vasoconstriction - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Byrne, J.V.</creatorcontrib><creatorcontrib>Griffith, T.M.</creatorcontrib><creatorcontrib>Edwards, D.H.</creatorcontrib><creatorcontrib>Harrison, T.J.</creatorcontrib><creatorcontrib>Johnston, K.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Byrne, J.V.</au><au>Griffith, T.M.</au><au>Edwards, D.H.</au><au>Harrison, T.J.</au><au>Johnston, K.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the vasoconstrictor action of subarachnoid haemoglobin in the pig cerebral circulation in vivo</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1989-07</date><risdate>1989</risdate><volume>97</volume><issue>3</issue><spage>669</spage><epage>674</epage><pages>669-674</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
Angiographic techniques have been used to study the influence of intracisternally injected haemoglobin on the diameters of the main intrathecal and representative extrathecal (ascending pharyngeal and facial) cranial arteries of the anaesthetized pig.
2
Intracisternal injection of haemoglobin caused concentration‐dependent decreases in the diameters of intra‐ but not extrathecal arteries suggesting that haemoglobin possesses local vasoconstrictor activity.
3
When infused into one ascending pharyngeal artery, acetylcholine (ACh) caused slight dilatation of the intrathecal arteries but no change in the diameters of the ascending pharyngeal and facial arteries. The dilator response induced by ACh in the intrathecal arteries was converted into frank constriction after intracisternal injection of haemoglobin (cerebrospinal fluid concentration approximately 2 × 10−5 m).
4
These findings are consistent with the hypothesis that subarachnoid haemoglobin can induce cerebral artery constriction by acting as an extraluminal ‘sink’ for intimally released endothelium‐derived relaxing factor (EDRF) and may be relevant to the pathogenesis of vasospasm after subarachnoid haemorrhage in man.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2788022</pmid><doi>10.1111/j.1476-5381.1989.tb12002.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetylcholine - pharmacology Animals Arteries - anatomy & histology Arteries - drug effects Biological and medical sciences Biological Factors - pharmacology Cerebral Angiography Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - drug effects Fundamental and applied biological sciences. Psychology Hemoglobins - cerebrospinal fluid Humans Nitric Oxide Subarachnoid Hemorrhage - physiopathology Subarachnoid Space - drug effects Swine Vasoconstriction - drug effects Vertebrates: nervous system and sense organs |
| title | Investigation of the vasoconstrictor action of subarachnoid haemoglobin in the pig cerebral circulation in vivo |
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