Actions of bradykinin and related peptides on rabbit coeliac artery rings
1 Rabbit coeliac artery rings were mounted in tissue baths containing Krebs solution at 37°C in order to determine whether their response to bradykinin is initiated by B1 or B2‐receptors. Tension was recorded isometrically. 2 Phenylephrine contracted the tissue. Subsequent addition of bradykinin or...
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| Veröffentlicht in: | British journal of pharmacology 1989-01, Vol.96 (1), p.23-28 |
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| creator | Ritter, J.M. Doktor, H.S. Cragoe, E.J. |
| description | 1
Rabbit coeliac artery rings were mounted in tissue baths containing Krebs solution at 37°C in order to determine whether their response to bradykinin is initiated by B1 or B2‐receptors. Tension was recorded isometrically.
2
Phenylephrine contracted the tissue. Subsequent addition of bradykinin or des Arg10‐kallidin caused relaxation which was not dependent on an intact endothelium. Des Arg10‐kallidin, a B1‐receptor selective agonist, was more potent than bradykinin.
3
[β‐Thienyl alanyl6,9, D‐Phe8]‐kallidin and [Leu9]‐des Arg10‐kallidin antagonized bradykinin and des Arg10‐kallidin. [Leu9]‐des Arg10‐kallidin, a B1‐receptor selective antagonist, was more potent than [Thi69, D‐Phe8]‐kallidin, a less selective drug that acts on both B1 and B2‐receptors.
4
Kinin‐induced relaxation was reversibly antagonized by ibuprofen (a cyclo‐oxygenase inhibitor) and by 5‐(N,N‐hexamethylene)amiloride (an inhibitor of Na+/H+ exchange). Ibuprofen caused a parallel shift to the right of a semi‐logarithmic plot of the agonist concentration‐effect relationship, whereas the amiloride analogue depressed the maximum response and reduced the slope.
5
We conclude that bradykinin and des Arg10‐kallidin relax rabbit coeliac artery by combining with B1‐receptors. The response is mediated by a cyclo‐oxygenase product and may be influenced by cellular Na+/H+ exchange. |
| doi_str_mv | 10.1111/j.1476-5381.1989.tb11779.x |
| format | Article |
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Rabbit coeliac artery rings were mounted in tissue baths containing Krebs solution at 37°C in order to determine whether their response to bradykinin is initiated by B1 or B2‐receptors. Tension was recorded isometrically.
2
Phenylephrine contracted the tissue. Subsequent addition of bradykinin or des Arg10‐kallidin caused relaxation which was not dependent on an intact endothelium. Des Arg10‐kallidin, a B1‐receptor selective agonist, was more potent than bradykinin.
3
[β‐Thienyl alanyl6,9, D‐Phe8]‐kallidin and [Leu9]‐des Arg10‐kallidin antagonized bradykinin and des Arg10‐kallidin. [Leu9]‐des Arg10‐kallidin, a B1‐receptor selective antagonist, was more potent than [Thi69, D‐Phe8]‐kallidin, a less selective drug that acts on both B1 and B2‐receptors.
4
Kinin‐induced relaxation was reversibly antagonized by ibuprofen (a cyclo‐oxygenase inhibitor) and by 5‐(N,N‐hexamethylene)amiloride (an inhibitor of Na+/H+ exchange). Ibuprofen caused a parallel shift to the right of a semi‐logarithmic plot of the agonist concentration‐effect relationship, whereas the amiloride analogue depressed the maximum response and reduced the slope.
5
We conclude that bradykinin and des Arg10‐kallidin relax rabbit coeliac artery by combining with B1‐receptors. The response is mediated by a cyclo‐oxygenase product and may be influenced by cellular Na+/H+ exchange.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1989.tb11779.x</identifier><identifier>PMID: 2647202</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; arteries ; Biological and medical sciences ; Blood vessels and receptors ; bradykinin ; Bradykinin - pharmacology ; Celiac Artery - drug effects ; Fundamental and applied biological sciences. Psychology ; Ibuprofen - pharmacology ; In Vitro Techniques ; Methacholine Chloride ; Methacholine Compounds - pharmacology ; Muscle Contraction - drug effects ; Peptides - pharmacology ; Phenylephrine - pharmacology ; Rabbits ; sodium ; Vertebrates: cardiovascular system</subject><ispartof>British journal of pharmacology, 1989-01, Vol.96 (1), p.23-28</ispartof><rights>1989 British Pharmacological Society</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4539-9837dbb75b485536357f7dfc1d976b0b884410d051a6c6e23190a0fa4b5214ce3</citedby><cites>FETCH-LOGICAL-c4539-9837dbb75b485536357f7dfc1d976b0b884410d051a6c6e23190a0fa4b5214ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854316/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854316/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7269438$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2647202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ritter, J.M.</creatorcontrib><creatorcontrib>Doktor, H.S.</creatorcontrib><creatorcontrib>Cragoe, E.J.</creatorcontrib><title>Actions of bradykinin and related peptides on rabbit coeliac artery rings</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Rabbit coeliac artery rings were mounted in tissue baths containing Krebs solution at 37°C in order to determine whether their response to bradykinin is initiated by B1 or B2‐receptors. Tension was recorded isometrically.
2
Phenylephrine contracted the tissue. Subsequent addition of bradykinin or des Arg10‐kallidin caused relaxation which was not dependent on an intact endothelium. Des Arg10‐kallidin, a B1‐receptor selective agonist, was more potent than bradykinin.
3
[β‐Thienyl alanyl6,9, D‐Phe8]‐kallidin and [Leu9]‐des Arg10‐kallidin antagonized bradykinin and des Arg10‐kallidin. [Leu9]‐des Arg10‐kallidin, a B1‐receptor selective antagonist, was more potent than [Thi69, D‐Phe8]‐kallidin, a less selective drug that acts on both B1 and B2‐receptors.
4
Kinin‐induced relaxation was reversibly antagonized by ibuprofen (a cyclo‐oxygenase inhibitor) and by 5‐(N,N‐hexamethylene)amiloride (an inhibitor of Na+/H+ exchange). Ibuprofen caused a parallel shift to the right of a semi‐logarithmic plot of the agonist concentration‐effect relationship, whereas the amiloride analogue depressed the maximum response and reduced the slope.
5
We conclude that bradykinin and des Arg10‐kallidin relax rabbit coeliac artery by combining with B1‐receptors. The response is mediated by a cyclo‐oxygenase product and may be influenced by cellular Na+/H+ exchange.</description><subject>Animals</subject><subject>arteries</subject><subject>Biological and medical sciences</subject><subject>Blood vessels and receptors</subject><subject>bradykinin</subject><subject>Bradykinin - pharmacology</subject><subject>Celiac Artery - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ibuprofen - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Methacholine Chloride</subject><subject>Methacholine Compounds - pharmacology</subject><subject>Muscle Contraction - drug effects</subject><subject>Peptides - pharmacology</subject><subject>Phenylephrine - pharmacology</subject><subject>Rabbits</subject><subject>sodium</subject><subject>Vertebrates: cardiovascular system</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV9rFDEUxYNU6lr9CEIoxbcZcyfJJNMHsRa1hUL7oM8h_6ZmO5tZk1ntfnuz7rDYJzEvCZzfPZybg9ApkBrKebesgYm24lRCDZ3s6skACNHVj8_Q4iAdoQUhRFQAUr5AL3NeElJEwY_RcdMy0ZBmga4v7BTGmPHYY5O02z6EGCLW0eHkBz15h9d-PQXnCxJx0saECdvRD0FbrNPk0xanEO_zK_S810P2r-f7BH37_Onr5VV1c_vl-vLiprKM067qJBXOGMENk5zTlnLRC9dbcJ1oDTFSMgbEEQ66ta1vKHREk14zwxtg1tMT9H7vu96YlXfWxynpQa1TWOm0VaMO6qkSw3d1P_5UIDmj0BaDt7NBGn9sfJ7UKmTrh0FHP26yElKWjCD-CQIHWX4fCni-B20ac06-P6QBonaNqaXa1aJ2tahdY2puTD2W4Td_73MYnSsq-tms62z10CcdbcgHTDRtx6gs2Ic99isMfvsfAdTHu6s_T_obnQiz6A</recordid><startdate>198901</startdate><enddate>198901</enddate><creator>Ritter, J.M.</creator><creator>Doktor, H.S.</creator><creator>Cragoe, E.J.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198901</creationdate><title>Actions of bradykinin and related peptides on rabbit coeliac artery rings</title><author>Ritter, J.M. ; Doktor, H.S. ; Cragoe, E.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4539-9837dbb75b485536357f7dfc1d976b0b884410d051a6c6e23190a0fa4b5214ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>arteries</topic><topic>Biological and medical sciences</topic><topic>Blood vessels and receptors</topic><topic>bradykinin</topic><topic>Bradykinin - pharmacology</topic><topic>Celiac Artery - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ibuprofen - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Methacholine Chloride</topic><topic>Methacholine Compounds - pharmacology</topic><topic>Muscle Contraction - drug effects</topic><topic>Peptides - pharmacology</topic><topic>Phenylephrine - pharmacology</topic><topic>Rabbits</topic><topic>sodium</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ritter, J.M.</creatorcontrib><creatorcontrib>Doktor, H.S.</creatorcontrib><creatorcontrib>Cragoe, E.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ritter, J.M.</au><au>Doktor, H.S.</au><au>Cragoe, E.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Actions of bradykinin and related peptides on rabbit coeliac artery rings</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1989-01</date><risdate>1989</risdate><volume>96</volume><issue>1</issue><spage>23</spage><epage>28</epage><pages>23-28</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
Rabbit coeliac artery rings were mounted in tissue baths containing Krebs solution at 37°C in order to determine whether their response to bradykinin is initiated by B1 or B2‐receptors. Tension was recorded isometrically.
2
Phenylephrine contracted the tissue. Subsequent addition of bradykinin or des Arg10‐kallidin caused relaxation which was not dependent on an intact endothelium. Des Arg10‐kallidin, a B1‐receptor selective agonist, was more potent than bradykinin.
3
[β‐Thienyl alanyl6,9, D‐Phe8]‐kallidin and [Leu9]‐des Arg10‐kallidin antagonized bradykinin and des Arg10‐kallidin. [Leu9]‐des Arg10‐kallidin, a B1‐receptor selective antagonist, was more potent than [Thi69, D‐Phe8]‐kallidin, a less selective drug that acts on both B1 and B2‐receptors.
4
Kinin‐induced relaxation was reversibly antagonized by ibuprofen (a cyclo‐oxygenase inhibitor) and by 5‐(N,N‐hexamethylene)amiloride (an inhibitor of Na+/H+ exchange). Ibuprofen caused a parallel shift to the right of a semi‐logarithmic plot of the agonist concentration‐effect relationship, whereas the amiloride analogue depressed the maximum response and reduced the slope.
5
We conclude that bradykinin and des Arg10‐kallidin relax rabbit coeliac artery by combining with B1‐receptors. The response is mediated by a cyclo‐oxygenase product and may be influenced by cellular Na+/H+ exchange.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2647202</pmid><doi>10.1111/j.1476-5381.1989.tb11779.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals arteries Biological and medical sciences Blood vessels and receptors bradykinin Bradykinin - pharmacology Celiac Artery - drug effects Fundamental and applied biological sciences. Psychology Ibuprofen - pharmacology In Vitro Techniques Methacholine Chloride Methacholine Compounds - pharmacology Muscle Contraction - drug effects Peptides - pharmacology Phenylephrine - pharmacology Rabbits sodium Vertebrates: cardiovascular system |
| title | Actions of bradykinin and related peptides on rabbit coeliac artery rings |
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