Comparison of the effects of epithelium removal and of an enkephalinase inhibitor on the neurokinin‐induced contractions of guinea‐pig isolated trachea

1 The influence of epithelium removal and/or thiorphan on the effects of neurokinins (substance P (SP), neurokinin A (NKA), neurokinin B (NKB)) and related peptides on airway contractility was investigated on the guinea‐pig isolated trachea. 2 Removing the tracheal epithelium significantly enhanced...

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Veröffentlicht in:	British journal of pharmacology 1988-07, Vol.94 (3), p.675-684
Hauptverfasser:	Devillier, Philippe, Advenier, Charles, Drapeau, Guy, Marsac, Jean, Regoli, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Airway Resistance - drug effects Animals Biological and medical sciences Epithelium - physiology Fundamental and applied biological sciences. Psychology Guinea Pigs In Vitro Techniques Male Neprilysin - antagonists & inhibitors Neurokinin A - pharmacology Neurokinin B - pharmacology Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Substance P - pharmacology Tachykinins - pharmacology Thiorphan - pharmacology Trachea - drug effects Vertebrates: respiratory system
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