Indomethacin potentiates endotoxin‐induced blood flow reduction and histological injury in rat gastric mucosa

1 The effect of the intravenous administration of lipopolysaccharide from Salmonella typhosa endotoxin on arterial blood pressure (BP), gastric mucosal blood flow (GMBF) and gastric damage was studied in anaesthetized rats. The effect of the inhibition of endogenous prostaglandin generation by indom...

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Veröffentlicht in:	British journal of pharmacology 1988-04, Vol.93 (4), p.925-931
Hauptverfasser:	Piqué, Josep M., Yonei, Yoshikazu, Whittle, Brendan J.R., Leung, Felix W., Guth, Paul H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects Digestive system Dose-Response Relationship, Drug Drug Synergism Endotoxins - toxicity Gastric Mucosa - blood supply Gastric Mucosa - drug effects In Vitro Techniques Indomethacin - pharmacology Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Regional Blood Flow - drug effects Salmonella typhi Salmonella typhosa Shock, Septic - physiopathology Stomach Ulcer - chemically induced Stomach Ulcer - physiopathology
Online-Zugang:	Volltext
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