Functional and direct binding studies using subtype selective muscarinic receptor antagonists

1 Muscarinic receptor antagonists were examined in direct binding studies on guinea‐pig cardiac and cortical muscarinic receptors. Pirenzepine, dicyclomine and hexahydroadiphenine were shown to be selective ligands for the putative M1‐muscarinic receptor. 2 Functional affinity estimates of the musca...

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