Bay K 8644‐induced changes in the ECG pattern of the rat and their inhibition by antianginal drugs
1 The effects of intracarotid administration of Bay K 8644 on the ECG pattern along with their reversal by antianginal drugs were investigated in anaesthetized rats. 2 Intracarotid injections of Bay K 8644 (0.5–50.0 μg kg−1) produced a dose‐related transient increase in systemic blood pressure. 3 Th...
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| Veröffentlicht in: | British journal of pharmacology 1987-11, Vol.92 (3), p.603-608 |
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| container_title | British journal of pharmacology |
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| creator | Abraham, S. Amitai, G. Oz, N. Weissman, B.A. |
| description | 1
The effects of intracarotid administration of Bay K 8644 on the ECG pattern along with their reversal by antianginal drugs were investigated in anaesthetized rats.
2
Intracarotid injections of Bay K 8644 (0.5–50.0 μg kg−1) produced a dose‐related transient increase in systemic blood pressure.
3
The pressor response was accompanied by ST segment elevation (0.5–10.0 μgkg−1), ST segment depression concomitant with the occurrence of arrhythmias (20.0 μgkg−1), or A‐V block (50.0 μgkg−1).
4
ST segment elevation reached its maximal value within 15 s and could be observed for 30–240 s.
5
The increase in blood pressure was immediate (within 5 s) and short lasting (30–120 s). After the initial increase it returned to control levels (0.5–20.0 μgkg−1) or dropped below (50.0 μgkg−1).
6
The ST segment elevation caused by 5.0 μgkg−1 Bay K 8644 (submaximal dose) was blocked by antianginal drugs (e.g. nitroglycerin, nifedipine and diltiazem) and by the peripheral benzodiazepine receptor antagonist PK 11195. However, the pressor response was not blocked by any of the drugs used.
7
ST segment elevation (or depression) induced by intracarotid administration of Bay K 8644 provides a useful tool for the evaluation of potential antianginal drugs. |
| doi_str_mv | 10.1111/j.1476-5381.1987.tb11362.x |
| format | Article |
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The effects of intracarotid administration of Bay K 8644 on the ECG pattern along with their reversal by antianginal drugs were investigated in anaesthetized rats.
2
Intracarotid injections of Bay K 8644 (0.5–50.0 μg kg−1) produced a dose‐related transient increase in systemic blood pressure.
3
The pressor response was accompanied by ST segment elevation (0.5–10.0 μgkg−1), ST segment depression concomitant with the occurrence of arrhythmias (20.0 μgkg−1), or A‐V block (50.0 μgkg−1).
4
ST segment elevation reached its maximal value within 15 s and could be observed for 30–240 s.
5
The increase in blood pressure was immediate (within 5 s) and short lasting (30–120 s). After the initial increase it returned to control levels (0.5–20.0 μgkg−1) or dropped below (50.0 μgkg−1).
6
The ST segment elevation caused by 5.0 μgkg−1 Bay K 8644 (submaximal dose) was blocked by antianginal drugs (e.g. nitroglycerin, nifedipine and diltiazem) and by the peripheral benzodiazepine receptor antagonist PK 11195. However, the pressor response was not blocked by any of the drugs used.
7
ST segment elevation (or depression) induced by intracarotid administration of Bay K 8644 provides a useful tool for the evaluation of potential antianginal drugs.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1987.tb11362.x</identifier><identifier>PMID: 2447988</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - antagonists & inhibitors ; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology ; Animals ; Antianginal agents. Coronary vasodilator agents ; Atropine - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Carotid Arteries ; Diltiazem - pharmacology ; Dose-Response Relationship, Drug ; Electrocardiography ; Injections, Intra-Arterial ; Isoquinolines - pharmacology ; Male ; Medical sciences ; Nifedipine - pharmacology ; Nitroglycerin - pharmacology ; Pharmacology. Drug treatments ; Phentolamine - pharmacology ; Rats ; Rats, Inbred Strains</subject><ispartof>British journal of pharmacology, 1987-11, Vol.92 (3), p.603-608</ispartof><rights>1987 British Pharmacological Society</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5072-72a345f79d742a4bd3cbe4f95fe26d89f4b3ccea12e3af3e9e4c6f35657dcfb53</citedby><cites>FETCH-LOGICAL-c5072-72a345f79d742a4bd3cbe4f95fe26d89f4b3ccea12e3af3e9e4c6f35657dcfb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853702/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853702/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7849348$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2447988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abraham, S.</creatorcontrib><creatorcontrib>Amitai, G.</creatorcontrib><creatorcontrib>Oz, N.</creatorcontrib><creatorcontrib>Weissman, B.A.</creatorcontrib><title>Bay K 8644‐induced changes in the ECG pattern of the rat and their inhibition by antianginal drugs</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
The effects of intracarotid administration of Bay K 8644 on the ECG pattern along with their reversal by antianginal drugs were investigated in anaesthetized rats.
2
Intracarotid injections of Bay K 8644 (0.5–50.0 μg kg−1) produced a dose‐related transient increase in systemic blood pressure.
3
The pressor response was accompanied by ST segment elevation (0.5–10.0 μgkg−1), ST segment depression concomitant with the occurrence of arrhythmias (20.0 μgkg−1), or A‐V block (50.0 μgkg−1).
4
ST segment elevation reached its maximal value within 15 s and could be observed for 30–240 s.
5
The increase in blood pressure was immediate (within 5 s) and short lasting (30–120 s). After the initial increase it returned to control levels (0.5–20.0 μgkg−1) or dropped below (50.0 μgkg−1).
6
The ST segment elevation caused by 5.0 μgkg−1 Bay K 8644 (submaximal dose) was blocked by antianginal drugs (e.g. nitroglycerin, nifedipine and diltiazem) and by the peripheral benzodiazepine receptor antagonist PK 11195. However, the pressor response was not blocked by any of the drugs used.
7
ST segment elevation (or depression) induced by intracarotid administration of Bay K 8644 provides a useful tool for the evaluation of potential antianginal drugs.</description><subject>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - antagonists & inhibitors</subject><subject>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology</subject><subject>Animals</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Carotid Arteries</subject><subject>Diltiazem - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrocardiography</subject><subject>Injections, Intra-Arterial</subject><subject>Isoquinolines - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nifedipine - pharmacology</subject><subject>Nitroglycerin - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phentolamine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc1u1DAUhS0EKkPhEZAshNgl2LEdOyxQ6ah_ohIsYG05_pnxKOMMdgKdHY_AM_IkdTrRiC7xxlf3nHvulT4A3mBU4vzeb0pMeV0wInCJG8HLocWY1FV59wQsjtJTsEAI8QJjIZ6DFyltEMoiZyfgpKKUN0IsgDlXe_gZiprSv7__-GBGbQ3UaxVWNkEf4LC28GJ5BXdqGGwMsHcPragGqIKZah-zb-1bP_g-wHaf-4PP8z6oDpo4rtJL8MypLtlX838Kvl9efFteF7dfrm6Wn24LzRCvCl4pQpnjjeG0UrQ1RLeWuoY5W9VGNI62RGurcGWJcsQ2luraEVYzbrRrGTkFHw-5u7HdWqNtGKLq5C76rYp72SsvHyvBr-Wq_ymxYISjKge8mwNi_2O0aZBbn7TtOhVsPybJeYORQDQbPxyMOvYpReuOSzCSEyO5kRMIOYGQEyM5M5J3efj1v2ceR2coWX876ypp1bmogvbpaOOCNoROtrOD7Zfv7P4_DpDnX68fSnIPQ_GxGQ</recordid><startdate>198711</startdate><enddate>198711</enddate><creator>Abraham, S.</creator><creator>Amitai, G.</creator><creator>Oz, N.</creator><creator>Weissman, B.A.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198711</creationdate><title>Bay K 8644‐induced changes in the ECG pattern of the rat and their inhibition by antianginal drugs</title><author>Abraham, S. ; Amitai, G. ; Oz, N. ; Weissman, B.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5072-72a345f79d742a4bd3cbe4f95fe26d89f4b3ccea12e3af3e9e4c6f35657dcfb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - antagonists & inhibitors</topic><topic>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology</topic><topic>Animals</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular system</topic><topic>Carotid Arteries</topic><topic>Diltiazem - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrocardiography</topic><topic>Injections, Intra-Arterial</topic><topic>Isoquinolines - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nifedipine - pharmacology</topic><topic>Nitroglycerin - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phentolamine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abraham, S.</creatorcontrib><creatorcontrib>Amitai, G.</creatorcontrib><creatorcontrib>Oz, N.</creatorcontrib><creatorcontrib>Weissman, B.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abraham, S.</au><au>Amitai, G.</au><au>Oz, N.</au><au>Weissman, B.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bay K 8644‐induced changes in the ECG pattern of the rat and their inhibition by antianginal drugs</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1987-11</date><risdate>1987</risdate><volume>92</volume><issue>3</issue><spage>603</spage><epage>608</epage><pages>603-608</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
The effects of intracarotid administration of Bay K 8644 on the ECG pattern along with their reversal by antianginal drugs were investigated in anaesthetized rats.
2
Intracarotid injections of Bay K 8644 (0.5–50.0 μg kg−1) produced a dose‐related transient increase in systemic blood pressure.
3
The pressor response was accompanied by ST segment elevation (0.5–10.0 μgkg−1), ST segment depression concomitant with the occurrence of arrhythmias (20.0 μgkg−1), or A‐V block (50.0 μgkg−1).
4
ST segment elevation reached its maximal value within 15 s and could be observed for 30–240 s.
5
The increase in blood pressure was immediate (within 5 s) and short lasting (30–120 s). After the initial increase it returned to control levels (0.5–20.0 μgkg−1) or dropped below (50.0 μgkg−1).
6
The ST segment elevation caused by 5.0 μgkg−1 Bay K 8644 (submaximal dose) was blocked by antianginal drugs (e.g. nitroglycerin, nifedipine and diltiazem) and by the peripheral benzodiazepine receptor antagonist PK 11195. However, the pressor response was not blocked by any of the drugs used.
7
ST segment elevation (or depression) induced by intracarotid administration of Bay K 8644 provides a useful tool for the evaluation of potential antianginal drugs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2447988</pmid><doi>10.1111/j.1476-5381.1987.tb11362.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 1987-11, Vol.92 (3), p.603-608 |
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| subjects | 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - antagonists & inhibitors 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Animals Antianginal agents. Coronary vasodilator agents Atropine - pharmacology Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Carotid Arteries Diltiazem - pharmacology Dose-Response Relationship, Drug Electrocardiography Injections, Intra-Arterial Isoquinolines - pharmacology Male Medical sciences Nifedipine - pharmacology Nitroglycerin - pharmacology Pharmacology. Drug treatments Phentolamine - pharmacology Rats Rats, Inbred Strains |
| title | Bay K 8644‐induced changes in the ECG pattern of the rat and their inhibition by antianginal drugs |
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