Identification of pyruvate kinase as an antigen associated with Tourette syndrome
Immune responses to β-hemolytic streptococcal infections are hypothesized to trigger tic disorders and early-onset obsessive–compulsive disorder (OCD) in some pediatric populations. Here we identify the M1 isoform of the glycolytic enzyme, pyruvate kinase (PK) as an autoimmune target in Tourette syn...
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| Veröffentlicht in: | Journal of neuroimmunology 2006-12, Vol.181 (1), p.165-176 |
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| container_title | Journal of neuroimmunology |
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| creator | Kansy, Janice W. Katsovich, Liliya McIver, Kevin S. Pick, Jennifer Zabriskie, John B. Lombroso, Paul J. Leckman, James F. Bibb, James A. |
| description | Immune responses to β-hemolytic streptococcal infections are hypothesized to trigger tic disorders and early-onset obsessive–compulsive disorder (OCD) in some pediatric populations. Here we identify the M1 isoform of the glycolytic enzyme, pyruvate kinase (PK) as an autoimmune target in Tourette syndrome and associated disorders. Antibodies to PK reacted strongly with surface antigens of infectious strains of streptococcus, and antibodies to streptococcal M proteins reacted with PK. Moreover, immunoreactivity to PK in patients with exacerbated symptoms who had recently acquired a streptococcal infection was 7-fold higher compared to patients with exacerbated symptoms and no evidence of a streptococcal infection. These data suggest that PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, OCD, and associated disorders. |
| doi_str_mv | 10.1016/j.jneuroim.2006.08.007 |
| format | Article |
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Here we identify the M1 isoform of the glycolytic enzyme, pyruvate kinase (PK) as an autoimmune target in Tourette syndrome and associated disorders. Antibodies to PK reacted strongly with surface antigens of infectious strains of streptococcus, and antibodies to streptococcal M proteins reacted with PK. Moreover, immunoreactivity to PK in patients with exacerbated symptoms who had recently acquired a streptococcal infection was 7-fold higher compared to patients with exacerbated symptoms and no evidence of a streptococcal infection. 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Here we identify the M1 isoform of the glycolytic enzyme, pyruvate kinase (PK) as an autoimmune target in Tourette syndrome and associated disorders. Antibodies to PK reacted strongly with surface antigens of infectious strains of streptococcus, and antibodies to streptococcal M proteins reacted with PK. Moreover, immunoreactivity to PK in patients with exacerbated symptoms who had recently acquired a streptococcal infection was 7-fold higher compared to patients with exacerbated symptoms and no evidence of a streptococcal infection. These data suggest that PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, OCD, and associated disorders.</description><subject>Adolescent</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens - genetics</subject><subject>Antigens - immunology</subject><subject>Antigens - metabolism</subject><subject>Autoantibodies - blood</subject><subject>Autoimmunity</subject><subject>Brain - enzymology</subject><subject>Brain - immunology</subject><subject>Child</subject><subject>Cross Reactions</subject><subject>Group A β-hemolytic streptococci</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>Obsessive–compulsive disorder</subject><subject>PANDAS</subject><subject>Prospective Studies</subject><subject>Pyruvate kinase</subject><subject>Pyruvate Kinase - genetics</subject><subject>Pyruvate Kinase - immunology</subject><subject>Pyruvate Kinase - metabolism</subject><subject>Rats</subject><subject>Seroepidemiologic Studies</subject><subject>Streptococcal Infections - epidemiology</subject><subject>Streptococcal Infections - immunology</subject><subject>Streptococcus</subject><subject>Tics - genetics</subject><subject>Tics - immunology</subject><subject>Tics - metabolism</subject><subject>Tourette syndrome</subject><subject>Tourette Syndrome - epidemiology</subject><subject>Tourette Syndrome - genetics</subject><subject>Tourette Syndrome - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkduKFDEQhoMo7jj6CktfeddtVR9yuBFl8bCwIMJ6HTLp6t2M08mYpEfm7c0y4-lqIVAJ9dWfqvoZu0RoEJC_2TZbT0sMbm5aAN6AbADEE7ZCKdpa9i0-ZasCDvUgWnnBXqS0BcCh69VzdoECEHkPK_b1eiSf3eSsyS74KkzV_hiXg8lUfXfeJKpMqowvJ7s7KjGlYF1Jj9VPl--r27BEyoVORz_GMNNL9mwyu0SvznHNvn38cHv1ub758un66v1NbQeAXBMXk2mRVK8s4GbCfrJG2mkiVJ1Skg_K9GYjJJRLB7K8JMGGIxLythPdmr096e6XzUyjLWNEs9P76GYTjzoYp__PeHev78JBoxy6TkAReH0WiOHHQinr2SVLu53xFJakuWxBil49CqKSQ98V0TXjJ9DGkFKk6U83CPrBNr3Vv23TD7ZpkLrYVgov_53lb9nZpwK8OwFUNnpwFHWyjryl0UWyWY_BPfbHL31Mrsw</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Kansy, Janice W.</creator><creator>Katsovich, Liliya</creator><creator>McIver, Kevin S.</creator><creator>Pick, Jennifer</creator><creator>Zabriskie, John B.</creator><creator>Lombroso, Paul J.</creator><creator>Leckman, James F.</creator><creator>Bibb, James A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TK</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20061201</creationdate><title>Identification of pyruvate kinase as an antigen associated with Tourette syndrome</title><author>Kansy, Janice W. ; 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| subjects | Adolescent Amino Acid Sequence Animals Antibodies, Bacterial - blood Antigens - genetics Antigens - immunology Antigens - metabolism Autoantibodies - blood Autoimmunity Brain - enzymology Brain - immunology Child Cross Reactions Group A β-hemolytic streptococci Humans Immunohistochemistry Longitudinal Studies Male Mice Mice, Inbred C57BL Molecular Sequence Data Obsessive–compulsive disorder PANDAS Prospective Studies Pyruvate kinase Pyruvate Kinase - genetics Pyruvate Kinase - immunology Pyruvate Kinase - metabolism Rats Seroepidemiologic Studies Streptococcal Infections - epidemiology Streptococcal Infections - immunology Streptococcus Tics - genetics Tics - immunology Tics - metabolism Tourette syndrome Tourette Syndrome - epidemiology Tourette Syndrome - genetics Tourette Syndrome - immunology |
| title | Identification of pyruvate kinase as an antigen associated with Tourette syndrome |
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