Weak binding affinity of human 4EHP for mRNA cap analogs

Ribosome recruitment to the majority of eukaryotic mRNAs is facilitated by the interaction of the cap binding protein, eIF4E, with the mRNA 5' cap structure. eIF4E stimulates translation through its interaction with a scaffolding protein, eIF4G, which helps to recruit the ribosome. Metazoans al...

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Veröffentlicht in:	RNA (Cambridge) 2007-05, Vol.13 (5), p.691-697
Hauptverfasser:	Zuberek, Joanna, Kubacka, Dorota, Jablonowska, Agnieszka, Jemielity, Jacek, Stepinski, Janusz, Sonenberg, Nahum, Darzynkiewicz, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Binding Sites Binding, Competitive Dinucleoside Phosphates - metabolism Eukaryotic Initiation Factor-4E - metabolism Fluorescence Metazoa Molecular Sequence Data RNA Cap Analogs - chemistry RNA Cap Analogs - metabolism RNA Cap-Binding Proteins - genetics RNA Cap-Binding Proteins - metabolism RNA, Messenger - metabolism Titrimetry Tryptophan - metabolism Tyrosine - metabolism
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