Identification of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Nontarget Tissue
Background: Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest. Objectives: The objective of this study was to compare gene expression change...
Gespeichert in:
| Veröffentlicht in: | Environmental health perspectives 2007-04, Vol.115 (4), p.572-578 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 578 |
|---|---|
| container_issue | 4 |
| container_start_page | 572 |
| container_title | Environmental health perspectives |
| container_volume | 115 |
| creator | J. Todd Auman Jeff Chou Kevin Gerrish Huang, Qihong Jayadev, Supriya Blanchard, Kerry Paules, Richard S. |
| description | Background: Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest. Objectives: The objective of this study was to compare gene expression changes in a nontarget tissue to the target tissue for toxicity to help identify toxicity-related genes. Methods: Male rats were given the hepatotoxicant methapyrilene at two dose levels, with livers and kidneys removed 24 hr after one, three, and seven doses for gene expression analysis. To identify gene changes likely to be related to toxicity, we analyzed genes on the basis of their temporal pattern of change using a program developed at the National Institute of Environmental Health Sciences, termed "EPIG" (extracting gene expression patterns and identifying co-expressed genes). Results: High-dose methapyrilene elicited hepatic damage that increased in severity with the number of doses, whereas no treatment-related lesions were observed in the kidney. High-dose methapyrilene elicited thousands of gene changes in the liver at each time point, whereas many fewer gene changes were observed in the kidney. EPIG analysis identified patterns of gene expression correlated to the observed toxicity, including genes associated with endoplasmic reticulum stress and the unfolded protein response. Conclusions: By factoring in dose level, number of doses, and tissue into the analysis of gene expression elicited by methapyrilene, we were able to identify genes likely to not be implicated in toxicity, thereby allowing us to focus on a subset of genes to identify toxicity-related processes. |
| doi_str_mv | 10.1289/ehp.9396 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1852695</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A168423787</galeid><jstor_id>4150358</jstor_id><sourcerecordid>A168423787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c722t-393a123c4df6b440d096108c2629ddfb13f5d834080ff98f211af7235c1cbb1b3</originalsourceid><addsrcrecordid>eNqNkt-K1DAUxoso7rgKPoBI8WLRi47506bNjbCM6-7A6oKO3oY0TToZ2qQmqcw8hy9s6gzrjiwouQjJ-eU7J-d8SfIcgjlEFX0r18OcYkoeJDNYFCijFOUPkxkAFGakJMVJ8sT7DQAAVoQ8Tk5gmRcAITJLfi4baYJWWvCgrUmtSi-lkT5d9kM3Xcom1Sb9KMOaDzunuxjMlqYZRQxcyYEHG-xWCx12ab1LF7YfuNOmTd9rpaSbtHn3WzK92A5Oej9liYor7loZUm6a9JM1YX9aae9H-TR5pHjn5bPDfpp8_XCxWlxl1zeXy8X5dSZKhEKGKeYQYZE3itR5DhpACQSVQATRplE1xKpoKpyDCihFK4Ug5KpEuBBQ1DWs8Wnybq87jHUvGxGLdbxjg9M9dztmuWbHEaPXrLU_GKwKRGgRBc4OAs5-H6UPrNdeyK7jRtrRs5ixQICgf4Iwr0Cc2QS--gvc2NGZ2AWG0PQxXNAIZXuo5Z1k2igbqxNt7HEs0hqp4pTYOSRVjnBZlZGf38PH1chei3sfvDl6EJkgt6Hlo_ds-eXz_7M3347ZszvsWvIurL3txsl5_hh8vQeFs947qW6HAgGbHM-i49nk-Ii-vDvEP-DB4hF4sQc2Plh3G89hAXBR4V-8awTz</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222629359</pqid></control><display><type>article</type><title>Identification of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Nontarget Tissue</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>J. Todd Auman ; Jeff Chou ; Kevin Gerrish ; Huang, Qihong ; Jayadev, Supriya ; Blanchard, Kerry ; Paules, Richard S.</creator><creatorcontrib>J. Todd Auman ; Jeff Chou ; Kevin Gerrish ; Huang, Qihong ; Jayadev, Supriya ; Blanchard, Kerry ; Paules, Richard S.</creatorcontrib><description>Background: Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest. Objectives: The objective of this study was to compare gene expression changes in a nontarget tissue to the target tissue for toxicity to help identify toxicity-related genes. Methods: Male rats were given the hepatotoxicant methapyrilene at two dose levels, with livers and kidneys removed 24 hr after one, three, and seven doses for gene expression analysis. To identify gene changes likely to be related to toxicity, we analyzed genes on the basis of their temporal pattern of change using a program developed at the National Institute of Environmental Health Sciences, termed "EPIG" (extracting gene expression patterns and identifying co-expressed genes). Results: High-dose methapyrilene elicited hepatic damage that increased in severity with the number of doses, whereas no treatment-related lesions were observed in the kidney. High-dose methapyrilene elicited thousands of gene changes in the liver at each time point, whereas many fewer gene changes were observed in the kidney. EPIG analysis identified patterns of gene expression correlated to the observed toxicity, including genes associated with endoplasmic reticulum stress and the unfolded protein response. Conclusions: By factoring in dose level, number of doses, and tissue into the analysis of gene expression elicited by methapyrilene, we were able to identify genes likely to not be implicated in toxicity, thereby allowing us to focus on a subset of genes to identify toxicity-related processes.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.9396</identifier><identifier>PMID: 17450226</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Administered dose ; Animals ; Antihistamines ; Complications and side effects ; Dosage ; Dosage and administration ; Dose-Response Relationship, Drug ; Evaluation ; Gene expression ; Gene Expression Profiling ; Genes ; Genetic aspects ; Health aspects ; Hepatotoxicity ; Histamine H1 Antagonists - toxicity ; Kidney - drug effects ; Kidney - pathology ; Kidneys ; Liver ; Liver - drug effects ; Liver - pathology ; Liver cells ; Male ; Methapyrilene - toxicity ; Oxidative stress ; Physiological aspects ; Pyridine ; Rats ; Rats, Sprague-Dawley ; Receptors ; RNA ; Toxicogenetics ; Up-Regulation - drug effects</subject><ispartof>Environmental health perspectives, 2007-04, Vol.115 (4), p.572-578</ispartof><rights>COPYRIGHT 2007 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Apr 2007</rights><rights>2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c722t-393a123c4df6b440d096108c2629ddfb13f5d834080ff98f211af7235c1cbb1b3</citedby><cites>FETCH-LOGICAL-c722t-393a123c4df6b440d096108c2629ddfb13f5d834080ff98f211af7235c1cbb1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4150358$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4150358$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17450226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>J. Todd Auman</creatorcontrib><creatorcontrib>Jeff Chou</creatorcontrib><creatorcontrib>Kevin Gerrish</creatorcontrib><creatorcontrib>Huang, Qihong</creatorcontrib><creatorcontrib>Jayadev, Supriya</creatorcontrib><creatorcontrib>Blanchard, Kerry</creatorcontrib><creatorcontrib>Paules, Richard S.</creatorcontrib><title>Identification of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Nontarget Tissue</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Background: Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest. Objectives: The objective of this study was to compare gene expression changes in a nontarget tissue to the target tissue for toxicity to help identify toxicity-related genes. Methods: Male rats were given the hepatotoxicant methapyrilene at two dose levels, with livers and kidneys removed 24 hr after one, three, and seven doses for gene expression analysis. To identify gene changes likely to be related to toxicity, we analyzed genes on the basis of their temporal pattern of change using a program developed at the National Institute of Environmental Health Sciences, termed "EPIG" (extracting gene expression patterns and identifying co-expressed genes). Results: High-dose methapyrilene elicited hepatic damage that increased in severity with the number of doses, whereas no treatment-related lesions were observed in the kidney. High-dose methapyrilene elicited thousands of gene changes in the liver at each time point, whereas many fewer gene changes were observed in the kidney. EPIG analysis identified patterns of gene expression correlated to the observed toxicity, including genes associated with endoplasmic reticulum stress and the unfolded protein response. Conclusions: By factoring in dose level, number of doses, and tissue into the analysis of gene expression elicited by methapyrilene, we were able to identify genes likely to not be implicated in toxicity, thereby allowing us to focus on a subset of genes to identify toxicity-related processes.</description><subject>Administered dose</subject><subject>Animals</subject><subject>Antihistamines</subject><subject>Complications and side effects</subject><subject>Dosage</subject><subject>Dosage and administration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Evaluation</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hepatotoxicity</subject><subject>Histamine H1 Antagonists - toxicity</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Liver cells</subject><subject>Male</subject><subject>Methapyrilene - toxicity</subject><subject>Oxidative stress</subject><subject>Physiological aspects</subject><subject>Pyridine</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors</subject><subject>RNA</subject><subject>Toxicogenetics</subject><subject>Up-Regulation - drug effects</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkt-K1DAUxoso7rgKPoBI8WLRi47506bNjbCM6-7A6oKO3oY0TToZ2qQmqcw8hy9s6gzrjiwouQjJ-eU7J-d8SfIcgjlEFX0r18OcYkoeJDNYFCijFOUPkxkAFGakJMVJ8sT7DQAAVoQ8Tk5gmRcAITJLfi4baYJWWvCgrUmtSi-lkT5d9kM3Xcom1Sb9KMOaDzunuxjMlqYZRQxcyYEHG-xWCx12ab1LF7YfuNOmTd9rpaSbtHn3WzK92A5Oej9liYor7loZUm6a9JM1YX9aae9H-TR5pHjn5bPDfpp8_XCxWlxl1zeXy8X5dSZKhEKGKeYQYZE3itR5DhpACQSVQATRplE1xKpoKpyDCihFK4Ug5KpEuBBQ1DWs8Wnybq87jHUvGxGLdbxjg9M9dztmuWbHEaPXrLU_GKwKRGgRBc4OAs5-H6UPrNdeyK7jRtrRs5ixQICgf4Iwr0Cc2QS--gvc2NGZ2AWG0PQxXNAIZXuo5Z1k2igbqxNt7HEs0hqp4pTYOSRVjnBZlZGf38PH1chei3sfvDl6EJkgt6Hlo_ds-eXz_7M3347ZszvsWvIurL3txsl5_hh8vQeFs947qW6HAgGbHM-i49nk-Ii-vDvEP-DB4hF4sQc2Plh3G89hAXBR4V-8awTz</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>J. Todd Auman</creator><creator>Jeff Chou</creator><creator>Kevin Gerrish</creator><creator>Huang, Qihong</creator><creator>Jayadev, Supriya</creator><creator>Blanchard, Kerry</creator><creator>Paules, Richard S.</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><general>National Institute of Environmental Health Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>S0X</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20070401</creationdate><title>Identification of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Nontarget Tissue</title><author>J. Todd Auman ; Jeff Chou ; Kevin Gerrish ; Huang, Qihong ; Jayadev, Supriya ; Blanchard, Kerry ; Paules, Richard S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c722t-393a123c4df6b440d096108c2629ddfb13f5d834080ff98f211af7235c1cbb1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Administered dose</topic><topic>Animals</topic><topic>Antihistamines</topic><topic>Complications and side effects</topic><topic>Dosage</topic><topic>Dosage and administration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Evaluation</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hepatotoxicity</topic><topic>Histamine H1 Antagonists - toxicity</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Liver cells</topic><topic>Male</topic><topic>Methapyrilene - toxicity</topic><topic>Oxidative stress</topic><topic>Physiological aspects</topic><topic>Pyridine</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors</topic><topic>RNA</topic><topic>Toxicogenetics</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>J. Todd Auman</creatorcontrib><creatorcontrib>Jeff Chou</creatorcontrib><creatorcontrib>Kevin Gerrish</creatorcontrib><creatorcontrib>Huang, Qihong</creatorcontrib><creatorcontrib>Jayadev, Supriya</creatorcontrib><creatorcontrib>Blanchard, Kerry</creatorcontrib><creatorcontrib>Paules, Richard S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>J. Todd Auman</au><au>Jeff Chou</au><au>Kevin Gerrish</au><au>Huang, Qihong</au><au>Jayadev, Supriya</au><au>Blanchard, Kerry</au><au>Paules, Richard S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Nontarget Tissue</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>115</volume><issue>4</issue><spage>572</spage><epage>578</epage><pages>572-578</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Background: Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest. Objectives: The objective of this study was to compare gene expression changes in a nontarget tissue to the target tissue for toxicity to help identify toxicity-related genes. Methods: Male rats were given the hepatotoxicant methapyrilene at two dose levels, with livers and kidneys removed 24 hr after one, three, and seven doses for gene expression analysis. To identify gene changes likely to be related to toxicity, we analyzed genes on the basis of their temporal pattern of change using a program developed at the National Institute of Environmental Health Sciences, termed "EPIG" (extracting gene expression patterns and identifying co-expressed genes). Results: High-dose methapyrilene elicited hepatic damage that increased in severity with the number of doses, whereas no treatment-related lesions were observed in the kidney. High-dose methapyrilene elicited thousands of gene changes in the liver at each time point, whereas many fewer gene changes were observed in the kidney. EPIG analysis identified patterns of gene expression correlated to the observed toxicity, including genes associated with endoplasmic reticulum stress and the unfolded protein response. Conclusions: By factoring in dose level, number of doses, and tissue into the analysis of gene expression elicited by methapyrilene, we were able to identify genes likely to not be implicated in toxicity, thereby allowing us to focus on a subset of genes to identify toxicity-related processes.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>17450226</pmid><doi>10.1289/ehp.9396</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2007-04, Vol.115 (4), p.572-578 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1852695 |
| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Administered dose Animals Antihistamines Complications and side effects Dosage Dosage and administration Dose-Response Relationship, Drug Evaluation Gene expression Gene Expression Profiling Genes Genetic aspects Health aspects Hepatotoxicity Histamine H1 Antagonists - toxicity Kidney - drug effects Kidney - pathology Kidneys Liver Liver - drug effects Liver - pathology Liver cells Male Methapyrilene - toxicity Oxidative stress Physiological aspects Pyridine Rats Rats, Sprague-Dawley Receptors RNA Toxicogenetics Up-Regulation - drug effects |
| title | Identification of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Nontarget Tissue |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A14%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identification%20of%20Genes%20Implicated%20in%20Methapyrilene-Induced%20Hepatotoxicity%20by%20Comparing%20Differential%20Gene%20Expression%20in%20Target%20and%20Nontarget%20Tissue&rft.jtitle=Environmental%20health%20perspectives&rft.au=J.%20Todd%20Auman&rft.date=2007-04-01&rft.volume=115&rft.issue=4&rft.spage=572&rft.epage=578&rft.pages=572-578&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/ehp.9396&rft_dat=%3Cgale_pubme%3EA168423787%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222629359&rft_id=info:pmid/17450226&rft_galeid=A168423787&rft_jstor_id=4150358&rfr_iscdi=true |