Impact of solitary involved lymph node on outcome in localized cancer of the esophagus and esophagogastric junction
Node-positive esophageal cancer is associated with a dismal prognosis. The impact of a solitary involved node, however, is unclear, and this study examined the implications of a solitary node compared with greater nodal involvement and node-negative disease. The clinical and pathologic details of 60...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2007-04, Vol.11 (4), p.493-499 |
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| creator | O'Riordan, James M Rowley, Suzanne Murphy, James O Ravi, Narayasami Byrne, Patrick J Reynolds, John V |
| description | Node-positive esophageal cancer is associated with a dismal prognosis. The impact of a solitary involved node, however, is unclear, and this study examined the implications of a solitary node compared with greater nodal involvement and node-negative disease. The clinical and pathologic details of 604 patients were entered prospectively into a database from1993 and 2005. Four pathologic groups were analyzed: node-negative, one lymph node positive, two or three lymph nodes positive, and greater than three lymph nodes positive. Three hundred and fifteen patients (52%) were node-positive and 289 were node-negative. The median survival was 26 months in the node-negative group. Patients (n=84) who had one node positive had a median survival of 16 months (p=0.03 vs node-negative). Eighty-four patients who had two or three nodes positive had a median survival of 11 months compared with a median survival of 8 months in the 146 patients who had greater than three nodes positive (p=0.01). The survival of patients with one node positive [number of nodes (N)=1] was also significantly greater than the survival of patients with 2-3 nodes positive (N=2-3) (p=0.049) and greater than three nodes positive (p |
| doi_str_mv | 10.1007/s11605-006-0027-5 |
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The impact of a solitary involved node, however, is unclear, and this study examined the implications of a solitary node compared with greater nodal involvement and node-negative disease. The clinical and pathologic details of 604 patients were entered prospectively into a database from1993 and 2005. Four pathologic groups were analyzed: node-negative, one lymph node positive, two or three lymph nodes positive, and greater than three lymph nodes positive. Three hundred and fifteen patients (52%) were node-positive and 289 were node-negative. The median survival was 26 months in the node-negative group. Patients (n=84) who had one node positive had a median survival of 16 months (p=0.03 vs node-negative). Eighty-four patients who had two or three nodes positive had a median survival of 11 months compared with a median survival of 8 months in the 146 patients who had greater than three nodes positive (p=0.01). The survival of patients with one node positive [number of nodes (N)=1] was also significantly greater than the survival of patients with 2-3 nodes positive (N=2-3) (p=0.049) and greater than three nodes positive (p<0001). The presence of a solitary involved lymph node has a negative impact on survival compared with node-negative disease, but it is associated with significantly improved overall survival compared with all other nodal groups.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-006-0027-5</identifier><identifier>PMID: 17436135</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Aged ; Carcinoma - mortality ; Carcinoma - secondary ; Carcinoma - surgery ; Disease-Free Survival ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophagectomy ; Esophagogastric Junction ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Lymphatic system ; Medical research ; Middle Aged</subject><ispartof>Journal of gastrointestinal surgery, 2007-04, Vol.11 (4), p.493-499</ispartof><rights>Springer-Verlag 2007.</rights><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-8412bf08bbc143aacae9aeb3fdc2cc8e196b25b50fa4976300555e3fb1b442923</citedby><cites>FETCH-LOGICAL-c425t-8412bf08bbc143aacae9aeb3fdc2cc8e196b25b50fa4976300555e3fb1b442923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17436135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Riordan, James M</creatorcontrib><creatorcontrib>Rowley, Suzanne</creatorcontrib><creatorcontrib>Murphy, James O</creatorcontrib><creatorcontrib>Ravi, Narayasami</creatorcontrib><creatorcontrib>Byrne, Patrick J</creatorcontrib><creatorcontrib>Reynolds, John V</creatorcontrib><title>Impact of solitary involved lymph node on outcome in localized cancer of the esophagus and esophagogastric junction</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><description>Node-positive esophageal cancer is associated with a dismal prognosis. The impact of a solitary involved node, however, is unclear, and this study examined the implications of a solitary node compared with greater nodal involvement and node-negative disease. The clinical and pathologic details of 604 patients were entered prospectively into a database from1993 and 2005. Four pathologic groups were analyzed: node-negative, one lymph node positive, two or three lymph nodes positive, and greater than three lymph nodes positive. Three hundred and fifteen patients (52%) were node-positive and 289 were node-negative. The median survival was 26 months in the node-negative group. Patients (n=84) who had one node positive had a median survival of 16 months (p=0.03 vs node-negative). Eighty-four patients who had two or three nodes positive had a median survival of 11 months compared with a median survival of 8 months in the 146 patients who had greater than three nodes positive (p=0.01). The survival of patients with one node positive [number of nodes (N)=1] was also significantly greater than the survival of patients with 2-3 nodes positive (N=2-3) (p=0.049) and greater than three nodes positive (p<0001). The presence of a solitary involved lymph node has a negative impact on survival compared with node-negative disease, but it is associated with significantly improved overall survival compared with all other nodal groups.</description><subject>Aged</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - secondary</subject><subject>Carcinoma - surgery</subject><subject>Disease-Free Survival</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy</subject><subject>Esophagogastric Junction</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Medical research</subject><subject>Middle Aged</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkUuLHCEUhSUkZB7JD8gmCIHsKvH6KKs2gTAkmYGB2cxAdqKW1V2NpRW1Gia_fmy681yIyj3ncA8fQm-AfABC5McM0BLRENLWQ2UjnqFz6CRreEvb5_VNemioEN_P0EXOO0JAEuheojOQnLXAxDnKN_OibcFxxDn6qej0iKewj37vBuwf52WLQxwcjgHHtdg4uzrGPlrtp59VYnWwLh3sZeuwy3HZ6s2asQ7Dr1_c6FzSZPFuDbZMMbxCL0bts3t9ui_Rw9cv91fXze3dt5urz7eN5VSUpuNAzUg6YyxwprXVrtfOsHGw1NrOQd8aKowgo-a9bBkhQgjHRgOGc9pTdok-HXOX1cxusC6UpL1a0jTXmirqSf07CdNWbeJeQScok6wGvD8FpPhjdbmoecrWea-Di2tWkjDZtYxX4bv_hLu4plDLKQCglLWCy6qCo8qmmHNy4-9VgKgDUHUEqipQdQCqRPW8_bvDH8eJIHsCL5ue3A</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>O'Riordan, James M</creator><creator>Rowley, Suzanne</creator><creator>Murphy, James O</creator><creator>Ravi, Narayasami</creator><creator>Byrne, Patrick J</creator><creator>Reynolds, John V</creator><general>Springer Nature B.V</general><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070401</creationdate><title>Impact of solitary involved lymph node on outcome in localized cancer of the esophagus and esophagogastric junction</title><author>O'Riordan, James M ; 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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Carcinoma - mortality Carcinoma - secondary Carcinoma - surgery Disease-Free Survival Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagectomy Esophagogastric Junction Humans Lymph Node Excision Lymphatic Metastasis Lymphatic system Medical research Middle Aged |
| title | Impact of solitary involved lymph node on outcome in localized cancer of the esophagus and esophagogastric junction |
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