Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes

We have previously shown that stretching cardiac myocytes evokes activation of protein kinase C (PKC), mitogen-activated protein kinases (MAPKs), and 90-kD ribosomal S6 kinase (p90rsk). To clarify the signal transduction pathways from external mechanical stress to nuclear gene expression in stretch-...

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Veröffentlicht in:	The Journal of clinical investigation 1995-07, Vol.96 (1), p.438-446
Hauptverfasser:	Yamazaki, T, Komuro, I, Kudoh, S, Zou, Y, Shiojima, I, Mizuno, T, Takano, H, Hiroi, Y, Ueki, K, Tobe, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiotensin II - pharmacology Animals Animals, Newborn Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cardiomegaly - metabolism Cells, Cultured Enzyme Activation MAP Kinase Kinase Kinases Molecular Sequence Data Myocardium - metabolism Phosphorylation Protein Kinase C - physiology Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-raf Rats Rats, Wistar Ribosomal Protein S6 Kinases Signal Transduction Space life sciences Stress, Mechanical
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