Vascular Endothelial Growth Factor Isoforms and Their Receptors Are Expressed in Human Osteoarthritic Cartilage

To assess the possible involvement of vascular endothelial growth factor (VEGF) in the pathology of osteoarthritic (OA) cartilage, we examined the expression of VEGF isoforms and their receptors in the articular cartilage, and the effects of VEGF on the production of matrix metalloproteinases (MMPs)...

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Veröffentlicht in:	The American journal of pathology 2003, Vol.162 (1), p.171-181
Hauptverfasser:	Enomoto, Hiroyuki, Inoki, Isao, Komiya, Koichiro, Shiomi, Takayuki, Ikeda, Eiji, Obata, Ken-ichi, Matsumoto, Hideo, Toyama, Yoshiaki, Okada, Yasunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Division - drug effects Cells, Cultured Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Culture Media, Conditioned - metabolism Diseases of the osteoarticular system Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - genetics Endothelial Growth Factors - pharmacology Humans Immunohistochemistry In Situ Hybridization In Vitro Techniques Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - pharmacology Lymphokines - biosynthesis Lymphokines - genetics Lymphokines - pharmacology Matrix Metalloproteinases - metabolism Medical sciences Osteoarthritis Osteoarthritis - metabolism Osteoarthritis - pathology Protein Isoforms - biosynthesis Protein Isoforms - genetics Receptors, Vascular Endothelial Growth Factor - biosynthesis Receptors, Vascular Endothelial Growth Factor - genetics Reference Values Regular RNA, Messenger - biosynthesis Tissue Inhibitor of Metalloproteinase-1 - metabolism Tissue Inhibitor of Metalloproteinase-2 - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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