Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome
While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. In a previous study of 78 breast carcinoma specimens, we noted an associa...
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| Veröffentlicht in: | The American journal of pathology 2002-12, Vol.161 (6), p.1991-1996 |
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| container_end_page | 1996 |
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| container_issue | 6 |
| container_start_page | 1991 |
| container_title | The American journal of pathology |
| container_volume | 161 |
| creator | van de Rijn, Matt Perou, Charles M. Tibshirani, Rob Haas, Phillippe Kallioniemi, Olli Kononen, Juha Torhorst, Joachim Sauter, Guido Zuber, Markus Köchli, Ossi R. Mross, Frank Dieterich, Holger Seitz, Rob Ross, Doug Botstein, David Brown, Pat |
| description | While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. In a previous study of 78 breast carcinoma specimens, we noted an association between poor clinical outcome and the expression of cytokeratin 17 and/or cytokeratin 5 mRNAs. Here we describe the results of immunohistochemistry studies using monoclonal antibodies against these markers to analyze more than 600 paraffin-embedded breast tumors in tissue microarrays. We found that expression of cytokeratin 17 and/or cytokeratin 5/6 in tumor cells was associated with a poor clinical outcome. Moreover, multivariate analysis showed that in node-negative breast carcinoma, expression of these cytokeratins was a prognostic factor independent of tumor size and tumor grade. |
| doi_str_mv | 10.1016/S0002-9440(10)64476-8 |
| format | Article |
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Better predictive markers are needed to help guide difficult treatment decisions. In a previous study of 78 breast carcinoma specimens, we noted an association between poor clinical outcome and the expression of cytokeratin 17 and/or cytokeratin 5 mRNAs. Here we describe the results of immunohistochemistry studies using monoclonal antibodies against these markers to analyze more than 600 paraffin-embedded breast tumors in tissue microarrays. We found that expression of cytokeratin 17 and/or cytokeratin 5/6 in tumor cells was associated with a poor clinical outcome. Moreover, multivariate analysis showed that in node-negative breast carcinoma, expression of these cytokeratins was a prognostic factor independent of tumor size and tumor grade.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>DOI: 10.1016/S0002-9440(10)64476-8</identifier><identifier>PMID: 12466114</identifier><identifier>CODEN: AJPAA4</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Breast - cytology ; Breast - metabolism ; Breast Neoplasms - diagnosis ; Breast Neoplasms - pathology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Keratin-5 ; Keratins - genetics ; Keratins - metabolism ; Mammary gland diseases ; Medical sciences ; Neoplasm Staging ; Oligonucleotide Array Sequence Analysis ; Prognosis ; Short Communications ; Survival Rate ; Treatment Outcome ; Tumors</subject><ispartof>The American journal of pathology, 2002-12, Vol.161 (6), p.1991-1996</ispartof><rights>2002 American Society for Investigative Pathology</rights><rights>2003 INIST-CNRS</rights><rights>Copyright American Society for Investigative Pathology Dec 2002</rights><rights>Copyright © 2002, American Society for Investigative Pathology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-f998eeb24ac9f7e88ca71447835a847399eedeb21ab6cb4b00c27ccf3f011c973</citedby><cites>FETCH-LOGICAL-c552t-f998eeb24ac9f7e88ca71447835a847399eedeb21ab6cb4b00c27ccf3f011c973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850928/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9440(10)64476-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3550,27924,27925,45995,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14399322$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12466114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van de Rijn, Matt</creatorcontrib><creatorcontrib>Perou, Charles M.</creatorcontrib><creatorcontrib>Tibshirani, Rob</creatorcontrib><creatorcontrib>Haas, Phillippe</creatorcontrib><creatorcontrib>Kallioniemi, Olli</creatorcontrib><creatorcontrib>Kononen, Juha</creatorcontrib><creatorcontrib>Torhorst, Joachim</creatorcontrib><creatorcontrib>Sauter, Guido</creatorcontrib><creatorcontrib>Zuber, Markus</creatorcontrib><creatorcontrib>Köchli, Ossi R.</creatorcontrib><creatorcontrib>Mross, Frank</creatorcontrib><creatorcontrib>Dieterich, Holger</creatorcontrib><creatorcontrib>Seitz, Rob</creatorcontrib><creatorcontrib>Ross, Doug</creatorcontrib><creatorcontrib>Botstein, David</creatorcontrib><creatorcontrib>Brown, Pat</creatorcontrib><title>Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. In a previous study of 78 breast carcinoma specimens, we noted an association between poor clinical outcome and the expression of cytokeratin 17 and/or cytokeratin 5 mRNAs. Here we describe the results of immunohistochemistry studies using monoclonal antibodies against these markers to analyze more than 600 paraffin-embedded breast tumors in tissue microarrays. We found that expression of cytokeratin 17 and/or cytokeratin 5/6 in tumor cells was associated with a poor clinical outcome. Moreover, multivariate analysis showed that in node-negative breast carcinoma, expression of these cytokeratins was a prognostic factor independent of tumor size and tumor grade.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast - cytology</subject><subject>Breast - metabolism</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - pathology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratin-5</subject><subject>Keratins - genetics</subject><subject>Keratins - metabolism</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Prognosis</subject><subject>Short Communications</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9v1DAQxSMEokvhI4AsJP4dAh7HcewLCFalVKpUJOBseZ1J10tib-2kpd8ep7tqgQsnazy_eXozryieAn0LFMS7b5RSVirO6WugbwTnjSjlvWIBNatLBgruF4tb5KB4lNIml6KS9GFxAIwLAcAXRXf0axsxJRc8CR1ZXo_hJ0YzOp8INMT4ltTkpEU_us5hIoYcxzBtZ_ZTRJNGsjTROh8Gk8iVG9fkawiRLHvnnTU9OZtGGwZ8XDzoTJ_wyf49LH58Pvq-_FKenh2fLD-elrau2Vh2SknEFePGqq5BKa1pIK8mq9pI3lRKIba5D2Yl7IqvKLWssbarOgpgVVMdFu93uttpNWBrs-9oer2NbjDxWgfj9N8d79b6PFxqkDVVTGaBl3uBGC4mTKMeXLLY98ZjmJJuWFMJyngGn_8DbsIUfV5OM5BK1kLOavUOsjGkFLG7dQJUzzHqmxj1nNH8dROjnuee_bnG3dQ-twy82AMm5TN30Xjr0h3H86kqxjL3aset3fn6ykXUaTB9n2VBm80WBGihQSnI5IcdiTmeS4dRJ-vQW2zzlB11G9x_TP8GdK_Hcw</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>van de Rijn, Matt</creator><creator>Perou, Charles M.</creator><creator>Tibshirani, Rob</creator><creator>Haas, Phillippe</creator><creator>Kallioniemi, Olli</creator><creator>Kononen, Juha</creator><creator>Torhorst, Joachim</creator><creator>Sauter, Guido</creator><creator>Zuber, Markus</creator><creator>Köchli, Ossi R.</creator><creator>Mross, Frank</creator><creator>Dieterich, Holger</creator><creator>Seitz, Rob</creator><creator>Ross, Doug</creator><creator>Botstein, David</creator><creator>Brown, Pat</creator><general>Elsevier Inc</general><general>ASIP</general><general>American Society for Investigative Pathology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20021201</creationdate><title>Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome</title><author>van de Rijn, Matt ; Perou, Charles M. ; Tibshirani, Rob ; Haas, Phillippe ; Kallioniemi, Olli ; Kononen, Juha ; Torhorst, Joachim ; Sauter, Guido ; Zuber, Markus ; Köchli, Ossi R. ; Mross, Frank ; Dieterich, Holger ; Seitz, Rob ; Ross, Doug ; Botstein, David ; Brown, Pat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-f998eeb24ac9f7e88ca71447835a847399eedeb21ab6cb4b00c27ccf3f011c973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast - cytology</topic><topic>Breast - metabolism</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - pathology</topic><topic>Female</topic><topic>Gynecology. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); PubMed Central |
| subjects | Animals Biological and medical sciences Biomarkers, Tumor - metabolism Breast - cytology Breast - metabolism Breast Neoplasms - diagnosis Breast Neoplasms - pathology Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Keratin-5 Keratins - genetics Keratins - metabolism Mammary gland diseases Medical sciences Neoplasm Staging Oligonucleotide Array Sequence Analysis Prognosis Short Communications Survival Rate Treatment Outcome Tumors |
| title | Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome |
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