Mucosa-Associated Lymphoid Tissue Lymphomas with t(11;18)(q21;q21) and Mucosa-Associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways
t(11;18)(q21;q21) and aneuploidy are recurrent chromosomal aberrations in mucosa-associated lymphoid tissue (MALT) lymphomas. To investigate their relationship and clinical significance, we developed a two-color fluorescence in situ hybridization (FISH) technique to detect t(11;18) and aneuploidy in...
Gespeichert in:
| Veröffentlicht in: | The American journal of pathology 2002-07, Vol.161 (1), p.63-71 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 71 |
|---|---|
| container_issue | 1 |
| container_start_page | 63 |
| container_title | The American journal of pathology |
| container_volume | 161 |
| creator | Remstein, Ellen D. Kurtin, Paul J. James, C. David Wang, Xiao-Yang Meyer, Reid G. Dewald, Gordon W. |
| description | t(11;18)(q21;q21) and aneuploidy are recurrent chromosomal aberrations in mucosa-associated lymphoid tissue (MALT) lymphomas. To investigate their relationship and clinical significance, we developed a two-color fluorescence
in situ
hybridization (FISH) technique to detect t(11;18) and aneuploidy in nuclei isolated from paraffin-embedded tissue. Thirty-seven MALT lymphomas (all previously evaluated for t(11;18) by reverse transcriptase-polymerase chain reaction), 1 large cell lymphoma (LCL) arising subsequent to MALT lymphoma, and 16 controls were tested by FISH using the t(11;18) probe set and multiple centromeric probes. t(11;18)(q21;q21) was present by FISH in 11 of 12 polymerase chain reaction-positive MALT lymphomas (92%). The LCL and its clonally identical antecedent MALT lymphoma both showed t(11;18). The LCL had trisomy 12, and a small subset of MALT lymphoma cells had trisomy 3 and/or 12. Only one other MALT lymphoma with t(11;18) showed aneuploidy (trisomy 3) in a small clone, whereas 15 of 25 t(11;18)-negative MALT lymphomas (60%) showed trisomy of chromosomes 18 (
n
= 12), 3 (
n
= 8), 7 (
n
= 2), and/or 11 (
n
= 1). t(11;18) and aneuploidy are primarily mutually exclusive events, suggesting different pathogenetic pathways in the development of MALT lymphomas. Both t(11;18) and aneuploidy were seen disproportionately in lung, and both were associated with recurrent disease. |
| doi_str_mv | 10.1016/S0002-9440(10)64157-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1850705</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002944010641570</els_id><sourcerecordid>71888918</sourcerecordid><originalsourceid>FETCH-LOGICAL-c523t-29bd83d285bd5adad14149918a53c621cb71e4426981708dbab65011be5a57dd3</originalsourceid><addsrcrecordid>eNqVkd1u1DAQhSMEotvCI4ByA9q9CHiSOHFUqWjV8ictAolybU3s2Y2rJE7jZFf7Vn1EvD_qwhXiwrLG883x0ZwgeAXsHTDI3v9kjMVRkaZsCmyWpcDziD0JJsBjHsVQwNNg8oicBefO3fkySwR7HpxBDCxnBZsED99GZR1Gc-esMjiQDhfbpqus0eGtcW6kY92gCzdmqMJhCnAJYja9j-HSn1mIrQ7_W2be0tjVvr8Nb2hNte3CeW3bVXhjlkvqqR3CHzhUdkUtDUbtiw1u3Yvg2RJrRy-P90Xw69PH2-sv0eL756_X80WkeJwMUVyUWiQ6FrzUHDVqSCEtChDIE5XFoMocKE3jrBCQM6FLLDPOAEriyHOtk4vg6qDbjWVDWnlDPday602D_VZaNPLvTmsqubJrCYL73XIv8PYo0Nv7kdwgG-MU1TW2ZEcncxBCeEMe5AdQ9da5npaPnwCTu6zlPmu5C3L3tM9aMj_3-k-Hp6ljuB54cwTQKayXPbbKuBOX5HmSZsWJq8yq2piepGuwrr0sSLzrIAMJMks89-HAkd_72lAvnTLUKtJ-Rg1SW_MPy78BAJTVmQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71888918</pqid></control><display><type>article</type><title>Mucosa-Associated Lymphoid Tissue Lymphomas with t(11;18)(q21;q21) and Mucosa-Associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Remstein, Ellen D. ; Kurtin, Paul J. ; James, C. David ; Wang, Xiao-Yang ; Meyer, Reid G. ; Dewald, Gordon W.</creator><creatorcontrib>Remstein, Ellen D. ; Kurtin, Paul J. ; James, C. David ; Wang, Xiao-Yang ; Meyer, Reid G. ; Dewald, Gordon W.</creatorcontrib><description>t(11;18)(q21;q21) and aneuploidy are recurrent chromosomal aberrations in mucosa-associated lymphoid tissue (MALT) lymphomas. To investigate their relationship and clinical significance, we developed a two-color fluorescence
in situ
hybridization (FISH) technique to detect t(11;18) and aneuploidy in nuclei isolated from paraffin-embedded tissue. Thirty-seven MALT lymphomas (all previously evaluated for t(11;18) by reverse transcriptase-polymerase chain reaction), 1 large cell lymphoma (LCL) arising subsequent to MALT lymphoma, and 16 controls were tested by FISH using the t(11;18) probe set and multiple centromeric probes. t(11;18)(q21;q21) was present by FISH in 11 of 12 polymerase chain reaction-positive MALT lymphomas (92%). The LCL and its clonally identical antecedent MALT lymphoma both showed t(11;18). The LCL had trisomy 12, and a small subset of MALT lymphoma cells had trisomy 3 and/or 12. Only one other MALT lymphoma with t(11;18) showed aneuploidy (trisomy 3) in a small clone, whereas 15 of 25 t(11;18)-negative MALT lymphomas (60%) showed trisomy of chromosomes 18 (
n
= 12), 3 (
n
= 8), 7 (
n
= 2), and/or 11 (
n
= 1). t(11;18) and aneuploidy are primarily mutually exclusive events, suggesting different pathogenetic pathways in the development of MALT lymphomas. Both t(11;18) and aneuploidy were seen disproportionately in lung, and both were associated with recurrent disease.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>DOI: 10.1016/S0002-9440(10)64157-0</identifier><identifier>PMID: 12107090</identifier><identifier>CODEN: AJPAA4</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aneuploidy ; Biological and medical sciences ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 12 ; Chromosomes, Human, Pair 18 ; Female ; Hematologic and hematopoietic diseases ; Humans ; In Situ Hybridization, Fluorescence ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, B-Cell, Marginal Zone - genetics ; Lymphoma, Large B-Cell, Diffuse - genetics ; Male ; Medical sciences ; Middle Aged ; Regular ; Translocation, Genetic ; Trisomy</subject><ispartof>The American journal of pathology, 2002-07, Vol.161 (1), p.63-71</ispartof><rights>2002 American Society for Investigative Pathology</rights><rights>2002 INIST-CNRS</rights><rights>Copyright © 2002, American Society for Investigative Pathology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-29bd83d285bd5adad14149918a53c621cb71e4426981708dbab65011be5a57dd3</citedby><cites>FETCH-LOGICAL-c523t-29bd83d285bd5adad14149918a53c621cb71e4426981708dbab65011be5a57dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850705/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002944010641570$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3537,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13773469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12107090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Remstein, Ellen D.</creatorcontrib><creatorcontrib>Kurtin, Paul J.</creatorcontrib><creatorcontrib>James, C. David</creatorcontrib><creatorcontrib>Wang, Xiao-Yang</creatorcontrib><creatorcontrib>Meyer, Reid G.</creatorcontrib><creatorcontrib>Dewald, Gordon W.</creatorcontrib><title>Mucosa-Associated Lymphoid Tissue Lymphomas with t(11;18)(q21;q21) and Mucosa-Associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>t(11;18)(q21;q21) and aneuploidy are recurrent chromosomal aberrations in mucosa-associated lymphoid tissue (MALT) lymphomas. To investigate their relationship and clinical significance, we developed a two-color fluorescence
in situ
hybridization (FISH) technique to detect t(11;18) and aneuploidy in nuclei isolated from paraffin-embedded tissue. Thirty-seven MALT lymphomas (all previously evaluated for t(11;18) by reverse transcriptase-polymerase chain reaction), 1 large cell lymphoma (LCL) arising subsequent to MALT lymphoma, and 16 controls were tested by FISH using the t(11;18) probe set and multiple centromeric probes. t(11;18)(q21;q21) was present by FISH in 11 of 12 polymerase chain reaction-positive MALT lymphomas (92%). The LCL and its clonally identical antecedent MALT lymphoma both showed t(11;18). The LCL had trisomy 12, and a small subset of MALT lymphoma cells had trisomy 3 and/or 12. Only one other MALT lymphoma with t(11;18) showed aneuploidy (trisomy 3) in a small clone, whereas 15 of 25 t(11;18)-negative MALT lymphomas (60%) showed trisomy of chromosomes 18 (
n
= 12), 3 (
n
= 8), 7 (
n
= 2), and/or 11 (
n
= 1). t(11;18) and aneuploidy are primarily mutually exclusive events, suggesting different pathogenetic pathways in the development of MALT lymphomas. Both t(11;18) and aneuploidy were seen disproportionately in lung, and both were associated with recurrent disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Chromosomes, Human, Pair 12</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, B-Cell, Marginal Zone - genetics</subject><subject>Lymphoma, Large B-Cell, Diffuse - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Regular</subject><subject>Translocation, Genetic</subject><subject>Trisomy</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd1u1DAQhSMEotvCI4ByA9q9CHiSOHFUqWjV8ictAolybU3s2Y2rJE7jZFf7Vn1EvD_qwhXiwrLG883x0ZwgeAXsHTDI3v9kjMVRkaZsCmyWpcDziD0JJsBjHsVQwNNg8oicBefO3fkySwR7HpxBDCxnBZsED99GZR1Gc-esMjiQDhfbpqus0eGtcW6kY92gCzdmqMJhCnAJYja9j-HSn1mIrQ7_W2be0tjVvr8Nb2hNte3CeW3bVXhjlkvqqR3CHzhUdkUtDUbtiw1u3Yvg2RJrRy-P90Xw69PH2-sv0eL756_X80WkeJwMUVyUWiQ6FrzUHDVqSCEtChDIE5XFoMocKE3jrBCQM6FLLDPOAEriyHOtk4vg6qDbjWVDWnlDPday602D_VZaNPLvTmsqubJrCYL73XIv8PYo0Nv7kdwgG-MU1TW2ZEcncxBCeEMe5AdQ9da5npaPnwCTu6zlPmu5C3L3tM9aMj_3-k-Hp6ljuB54cwTQKayXPbbKuBOX5HmSZsWJq8yq2piepGuwrr0sSLzrIAMJMks89-HAkd_72lAvnTLUKtJ-Rg1SW_MPy78BAJTVmQ</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Remstein, Ellen D.</creator><creator>Kurtin, Paul J.</creator><creator>James, C. David</creator><creator>Wang, Xiao-Yang</creator><creator>Meyer, Reid G.</creator><creator>Dewald, Gordon W.</creator><general>Elsevier Inc</general><general>ASIP</general><general>American Society for Investigative Pathology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20020701</creationdate><title>Mucosa-Associated Lymphoid Tissue Lymphomas with t(11;18)(q21;q21) and Mucosa-Associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways</title><author>Remstein, Ellen D. ; Kurtin, Paul J. ; James, C. David ; Wang, Xiao-Yang ; Meyer, Reid G. ; Dewald, Gordon W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-29bd83d285bd5adad14149918a53c621cb71e4426981708dbab65011be5a57dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Chromosomes, Human, Pair 12</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, B-Cell, Marginal Zone - genetics</topic><topic>Lymphoma, Large B-Cell, Diffuse - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Regular</topic><topic>Translocation, Genetic</topic><topic>Trisomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Remstein, Ellen D.</creatorcontrib><creatorcontrib>Kurtin, Paul J.</creatorcontrib><creatorcontrib>James, C. David</creatorcontrib><creatorcontrib>Wang, Xiao-Yang</creatorcontrib><creatorcontrib>Meyer, Reid G.</creatorcontrib><creatorcontrib>Dewald, Gordon W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remstein, Ellen D.</au><au>Kurtin, Paul J.</au><au>James, C. David</au><au>Wang, Xiao-Yang</au><au>Meyer, Reid G.</au><au>Dewald, Gordon W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucosa-Associated Lymphoid Tissue Lymphomas with t(11;18)(q21;q21) and Mucosa-Associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>161</volume><issue>1</issue><spage>63</spage><epage>71</epage><pages>63-71</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><coden>AJPAA4</coden><abstract>t(11;18)(q21;q21) and aneuploidy are recurrent chromosomal aberrations in mucosa-associated lymphoid tissue (MALT) lymphomas. To investigate their relationship and clinical significance, we developed a two-color fluorescence
in situ
hybridization (FISH) technique to detect t(11;18) and aneuploidy in nuclei isolated from paraffin-embedded tissue. Thirty-seven MALT lymphomas (all previously evaluated for t(11;18) by reverse transcriptase-polymerase chain reaction), 1 large cell lymphoma (LCL) arising subsequent to MALT lymphoma, and 16 controls were tested by FISH using the t(11;18) probe set and multiple centromeric probes. t(11;18)(q21;q21) was present by FISH in 11 of 12 polymerase chain reaction-positive MALT lymphomas (92%). The LCL and its clonally identical antecedent MALT lymphoma both showed t(11;18). The LCL had trisomy 12, and a small subset of MALT lymphoma cells had trisomy 3 and/or 12. Only one other MALT lymphoma with t(11;18) showed aneuploidy (trisomy 3) in a small clone, whereas 15 of 25 t(11;18)-negative MALT lymphomas (60%) showed trisomy of chromosomes 18 (
n
= 12), 3 (
n
= 8), 7 (
n
= 2), and/or 11 (
n
= 1). t(11;18) and aneuploidy are primarily mutually exclusive events, suggesting different pathogenetic pathways in the development of MALT lymphomas. Both t(11;18) and aneuploidy were seen disproportionately in lung, and both were associated with recurrent disease.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>12107090</pmid><doi>10.1016/S0002-9440(10)64157-0</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9440 |
| ispartof | The American journal of pathology, 2002-07, Vol.161 (1), p.63-71 |
| issn | 0002-9440 1525-2191 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1850705 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Aged, 80 and over Aneuploidy Biological and medical sciences Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 18 Female Hematologic and hematopoietic diseases Humans In Situ Hybridization, Fluorescence Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell, Marginal Zone - genetics Lymphoma, Large B-Cell, Diffuse - genetics Male Medical sciences Middle Aged Regular Translocation, Genetic Trisomy |
| title | Mucosa-Associated Lymphoid Tissue Lymphomas with t(11;18)(q21;q21) and Mucosa-Associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T22%3A48%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mucosa-Associated%20Lymphoid%20Tissue%20Lymphomas%20with%20t(11;18)(q21;q21)%20and%20Mucosa-Associated%20Lymphoid%20Tissue%20Lymphomas%20with%20Aneuploidy%20Develop%20Along%20Different%20Pathogenetic%20Pathways&rft.jtitle=The%20American%20journal%20of%20pathology&rft.au=Remstein,%20Ellen%20D.&rft.date=2002-07-01&rft.volume=161&rft.issue=1&rft.spage=63&rft.epage=71&rft.pages=63-71&rft.issn=0002-9440&rft.eissn=1525-2191&rft.coden=AJPAA4&rft_id=info:doi/10.1016/S0002-9440(10)64157-0&rft_dat=%3Cproquest_pubme%3E71888918%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71888918&rft_id=info:pmid/12107090&rft_els_id=S0002944010641570&rfr_iscdi=true |