Differential Expression of Fibromodulin, a Transforming Growth Factor-β Modulator, in Fetal Skin Development and Scarless Repair

Transforming growth factor-β (TGF-β1, -β2, and -β3) has been implicated in the ontogenetic transition from scarless fetal repair to adult repair with scar. Generally, TGF-β exerts its effects through type I and II receptors; however, TGF-β modulators such as latent TGF-β binding protein-1 (LTBP-1),...

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Veröffentlicht in:	The American journal of pathology 2000-08, Vol.157 (2), p.423-433
Hauptverfasser:	Soo, Chia, Hu, Fei-Ya, Zhang, Xinli, Wang, Yubert, Beanes, Steven R., Lorenz, H. Peter, Hedrick, Marc H., Mackool, Richard J., Plaas, Ana, Kim, Soo-Jin, Longaker, Michael T., Freymiller, Earl, Ting, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biglycan Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Cicatrix - metabolism Decorin Dermatology Down-Regulation Extracellular Matrix Proteins Female Fetus Fibromodulin Gene Expression Gestational Age Immunohistochemistry Intracellular Signaling Peptides and Proteins Latent TGF-beta Binding Proteins Male Medical sciences Proteoglycans - metabolism Rats Rats, Sprague-Dawley Receptors, Transforming Growth Factor beta - metabolism Regular RNA, Messenger - genetics RNA, Messenger - metabolism Skin - embryology Skin - metabolism Skin - pathology Skin involvement in other diseases. Miscellaneous. General aspects Transforming Growth Factor beta - metabolism Up-Regulation Wound Healing - genetics
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