Neutrophils, Nitric Oxide Synthase, and Mutations in the Mutatect Murine Tumor Model

Mutatect MN-11 is a tumor line that can be grown subcutaneously in syngeneic C57BL/6 mice. The frequency of spontaneously arising mutants at the hypoxanthine phosphoribosyltransferase (Hprt) locus was observed to be elevated as a result of in vivo growth. The objective of the present study was to id...

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Veröffentlicht in:	The American journal of pathology 2000-02, Vol.156 (2), p.509-518
Hauptverfasser:	Sandhu, Jagdeep K., Privora, Helen F., Wenckebach, Georg, Birnboim, H. Chaim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Movement - drug effects Dinoprostone - pharmacology Drug Combinations Female Fibrosarcoma - enzymology Fibrosarcoma - genetics Fibrosarcoma - pathology Gene Frequency - drug effects General aspects Genetic Variation Immunohistochemistry Injections Injections, Subcutaneous Interleukin-8 - pharmacology Medical sciences Mice Mice, Inbred C57BL Mutation - genetics Neoplasm Transplantation - methods Neutrophils - drug effects Neutrophils - physiology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Regular Tumor Cells, Cultured Tumors Tyrosine - analogs & derivatives Tyrosine - metabolism
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