15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer

Prostaglandin E2 (PGE2) can stimulate tumor progression by modulating several proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and apoptosis. Although steady-state tissue levels of PGE2 stem from relative rates of biosynthesis and breakdown, most reports exami...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (5), p.3217-3223
Hauptverfasser:	Backlund, Michael G., Mann, Jason R., Holla, Vijaykumar R., Buchanan, F. Gregory, Tai, Hsin-Hsiung, Musiek, Erik S., Milne, Ginger L., Katkuri, Sharada, DuBois, Raymond N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colon - enzymology Colorectal Neoplasms - metabolism Colorectal Neoplasms - physiopathology Cyclooxygenase 2 Dinoprostone - metabolism Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Hydroxyprostaglandin Dehydrogenases - genetics Hydroxyprostaglandin Dehydrogenases - metabolism Membrane Proteins Mice Mice, Inbred C57BL Mice, Mutant Strains Prostaglandin-Endoperoxide Synthases - metabolism Tumor Cells, Cultured
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