Insulin-Like Growth Factor-I Stimulates Histone H3 and H4 Acetylation in the Brain in Vivo

IGF-I is essential to normal brain growth and exerts actions on neural stem cells and each major neural cell lineage. Whereas many studies show that IGF-I regulates gene expression, mechanisms by which it modulates transcription have not been explored. Chromatin modifications, such as histone phosph...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2006-11, Vol.147 (11), p.5480-5490
Hauptverfasser:	Sun, Liou Y, D’Ercole, A. Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation AKT protein Animals Biological and medical sciences Brain Brain - metabolism Brain architecture Cell lineage Chromatin Chromatin - metabolism DNA methylation Fundamental and applied biological sciences. Psychology Gene expression Gene regulation Growth factors Histone H3 Histones Histones - metabolism Immunohistochemistry In vivo methods and tests Insulin-Like Growth Factor Binding Protein 1 - physiology Insulin-like growth factor I Insulin-Like Growth Factor I - physiology Kinases Mice Mice, Transgenic Neural stem cells Phosphatidylinositol 3-Kinases - physiology Phosphorylation Proto-Oncogene Proteins c-akt - physiology Signal transduction Stem cells Transgenic mice Vertebrates: endocrinology
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