Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: A population-based study

Summary Polymorphisms in CYP1A1 and CYP1B1 genes in humans are associated with reduction of enzymatic activity towards several substrates, including those found in tobacco smoke. To investigate the potential role these polymorphisms have as modulators of early-onset lung cancer risk, a population-ba...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2007-03, Vol.55 (3), p.255-262
Hauptverfasser:	Cote, M.L, Wenzlaff, A.S, Bock, C.H, Land, S.J, Santer, S.K, Schwartz, D.R, Schwartz, A.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - ethnology Adenocarcinoma - genetics Adult African Americans African Americans - genetics Amino Acids, Branched-Chain - genetics Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Case-Control Studies Caucasians Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1B1 Cytochrome p-450 polymorphisms European Continental Ancestry Group - genetics Exons Female Genotype Hematology, Oncology and Palliative Medicine Humans Lung cancer Lung Neoplasms - ethnology Lung Neoplasms - genetics Male Medical sciences Pneumology Polymorphism, Genetic Pulmonary/Respiratory Smoking Smoking - ethnology Tobacco, tobacco smoking Toxicology Tumors Tumors of the respiratory system and mediastinum
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