Structural analysis of the basal ganglia in schizophrenia
Abstract Increases in the total volume of basal ganglia structures have been reported in schizophrenia. However, patterns of basal ganglia shape change, which can reveal localized changes in substructure volumes, have not been investigated. In this study, the total volume and shape of several basal...
Gespeichert in:
| Veröffentlicht in: | Schizophrenia research 2007-01, Vol.89 (1), p.59-71 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 71 |
|---|---|
| container_issue | 1 |
| container_start_page | 59 |
| container_title | Schizophrenia research |
| container_volume | 89 |
| creator | Mamah, Daniel Wang, Lei Barch, Deanna de Erausquin, Gabriel A Gado, Mokhtar Csernansky, John G |
| description | Abstract Increases in the total volume of basal ganglia structures have been reported in schizophrenia. However, patterns of basal ganglia shape change, which can reveal localized changes in substructure volumes, have not been investigated. In this study, the total volume and shape of several basal ganglia structures were compared in subjects with and without schizophrenia. T1 -weighted magnetic resonance scans were collected in 54 schizophrenia and 70 comparison subjects. High-dimensional (large-deformation) brain mapping was used to assess the shape and volume of several basal ganglia structures. The relationships of shape and volume measures with psychopathology, cognition and motor function were also assessed. Left and right volumes of the caudate and putamen, as well as the right globus pallidus volume, were significantly increased in subjects with schizophrenia as compared to comparison subjects after total brain volume was included as a covariate. Significant differences in shape accompanied these volume changes in the caudate, putamen and globus pallidus, after their total volumes were included as covariates. There were few significant correlations between volume or shape measures and either cognitive function or clinical symptoms, other than a positive correlation between an attention/vigilance cognitive dimension and the volume of the caudate and putamen, and a negative correlation between nucleus accumbens volume and delusions. In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences. |
| doi_str_mv | 10.1016/j.schres.2006.08.031 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1839817</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0920996406003860</els_id><sourcerecordid>1_s2_0_S0920996406003860</sourcerecordid><originalsourceid>FETCH-LOGICAL-c612t-9e7a1aec1a7411dd044a8cd77fc2445178e18a42c1be6f8b06c8951f340f28b53</originalsourceid><addsrcrecordid>eNqFkU2P0zAQhi0EYsvCP0AoF44JM44TOxcktFo-pJU4LJytiTNpXbJOZacrlV-Pq1YUuHCyZL8f42eEeI1QIWD7blslt4mcKgnQVmAqqPGJWGGj61I20D0VK-gklF3XqivxIqUtAGAD-rm4Qg0aodEr0d0vce-WfaSpoEDTIflUzGOxbLjoKeXbNYX15KnwociF_ue8y63B00vxbKQp8avzeS2-f7z9dvO5vPv66cvNh7vStSiXsmNNSOyQtEIcBlCKjBu0Hp1UqkFtGA0p6bDndjQ9tM50DY61glGavqmvxftT7m7fP_DgOCx5WLuL_oHiwc7k7d8vwW_sen60aOrOoM4B6hTg4pxS5PG3F8EeUdqtPaG0R5QWjM0os-3Nn70X05ldFrw9Cyg5msZIwfl00RmV06S8fIAzpUfPMbd5Do4HH9ktdpj9_yb5N8BNPvjc-YMPnLbzPubNJYs2SQv2_rj249ahBahNC_Uv3_-p2w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Structural analysis of the basal ganglia in schizophrenia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mamah, Daniel ; Wang, Lei ; Barch, Deanna ; de Erausquin, Gabriel A ; Gado, Mokhtar ; Csernansky, John G</creator><creatorcontrib>Mamah, Daniel ; Wang, Lei ; Barch, Deanna ; de Erausquin, Gabriel A ; Gado, Mokhtar ; Csernansky, John G</creatorcontrib><description>Abstract Increases in the total volume of basal ganglia structures have been reported in schizophrenia. However, patterns of basal ganglia shape change, which can reveal localized changes in substructure volumes, have not been investigated. In this study, the total volume and shape of several basal ganglia structures were compared in subjects with and without schizophrenia. T1 -weighted magnetic resonance scans were collected in 54 schizophrenia and 70 comparison subjects. High-dimensional (large-deformation) brain mapping was used to assess the shape and volume of several basal ganglia structures. The relationships of shape and volume measures with psychopathology, cognition and motor function were also assessed. Left and right volumes of the caudate and putamen, as well as the right globus pallidus volume, were significantly increased in subjects with schizophrenia as compared to comparison subjects after total brain volume was included as a covariate. Significant differences in shape accompanied these volume changes in the caudate, putamen and globus pallidus, after their total volumes were included as covariates. There were few significant correlations between volume or shape measures and either cognitive function or clinical symptoms, other than a positive correlation between an attention/vigilance cognitive dimension and the volume of the caudate and putamen, and a negative correlation between nucleus accumbens volume and delusions. In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2006.08.031</identifier><identifier>PMID: 17071057</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - adverse effects ; Antipsychotic Agents - therapeutic use ; Basal ganglia ; Basal Ganglia - drug effects ; Basal Ganglia - pathology ; Biological and medical sciences ; Brain Mapping ; Caudate ; Caudate Nucleus - drug effects ; Caudate Nucleus - pathology ; Delusions - diagnosis ; Delusions - drug therapy ; Dominance, Cerebral - physiology ; Dyskinesia, Drug-Induced - diagnosis ; Female ; Globus pallidus ; Globus Pallidus - drug effects ; Globus Pallidus - pathology ; High-dimensional brain mapping ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Neurologic Examination - drug effects ; Neuropsychological Tests ; Nucleus accumbens ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - pathology ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Putamen ; Putamen - drug effects ; Putamen - pathology ; Reference Values ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - drug therapy ; Schizophrenic Psychology ; Shape analysis ; Statistics as Topic ; Structural neuroimaging ; Wechsler Scales</subject><ispartof>Schizophrenia research, 2007-01, Vol.89 (1), p.59-71</ispartof><rights>Elsevier B.V.</rights><rights>2006 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c612t-9e7a1aec1a7411dd044a8cd77fc2445178e18a42c1be6f8b06c8951f340f28b53</citedby><cites>FETCH-LOGICAL-c612t-9e7a1aec1a7411dd044a8cd77fc2445178e18a42c1be6f8b06c8951f340f28b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0920996406003860$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18400622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17071057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mamah, Daniel</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Barch, Deanna</creatorcontrib><creatorcontrib>de Erausquin, Gabriel A</creatorcontrib><creatorcontrib>Gado, Mokhtar</creatorcontrib><creatorcontrib>Csernansky, John G</creatorcontrib><title>Structural analysis of the basal ganglia in schizophrenia</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Abstract Increases in the total volume of basal ganglia structures have been reported in schizophrenia. However, patterns of basal ganglia shape change, which can reveal localized changes in substructure volumes, have not been investigated. In this study, the total volume and shape of several basal ganglia structures were compared in subjects with and without schizophrenia. T1 -weighted magnetic resonance scans were collected in 54 schizophrenia and 70 comparison subjects. High-dimensional (large-deformation) brain mapping was used to assess the shape and volume of several basal ganglia structures. The relationships of shape and volume measures with psychopathology, cognition and motor function were also assessed. Left and right volumes of the caudate and putamen, as well as the right globus pallidus volume, were significantly increased in subjects with schizophrenia as compared to comparison subjects after total brain volume was included as a covariate. Significant differences in shape accompanied these volume changes in the caudate, putamen and globus pallidus, after their total volumes were included as covariates. There were few significant correlations between volume or shape measures and either cognitive function or clinical symptoms, other than a positive correlation between an attention/vigilance cognitive dimension and the volume of the caudate and putamen, and a negative correlation between nucleus accumbens volume and delusions. In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Basal ganglia</subject><subject>Basal Ganglia - drug effects</subject><subject>Basal Ganglia - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Caudate</subject><subject>Caudate Nucleus - drug effects</subject><subject>Caudate Nucleus - pathology</subject><subject>Delusions - diagnosis</subject><subject>Delusions - drug therapy</subject><subject>Dominance, Cerebral - physiology</subject><subject>Dyskinesia, Drug-Induced - diagnosis</subject><subject>Female</subject><subject>Globus pallidus</subject><subject>Globus Pallidus - drug effects</subject><subject>Globus Pallidus - pathology</subject><subject>High-dimensional brain mapping</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurologic Examination - drug effects</subject><subject>Neuropsychological Tests</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - pathology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Putamen</subject><subject>Putamen - drug effects</subject><subject>Putamen - pathology</subject><subject>Reference Values</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenic Psychology</subject><subject>Shape analysis</subject><subject>Statistics as Topic</subject><subject>Structural neuroimaging</subject><subject>Wechsler Scales</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EYsvCP0AoF44JM44TOxcktFo-pJU4LJytiTNpXbJOZacrlV-Pq1YUuHCyZL8f42eEeI1QIWD7blslt4mcKgnQVmAqqPGJWGGj61I20D0VK-gklF3XqivxIqUtAGAD-rm4Qg0aodEr0d0vce-WfaSpoEDTIflUzGOxbLjoKeXbNYX15KnwociF_ue8y63B00vxbKQp8avzeS2-f7z9dvO5vPv66cvNh7vStSiXsmNNSOyQtEIcBlCKjBu0Hp1UqkFtGA0p6bDndjQ9tM50DY61glGavqmvxftT7m7fP_DgOCx5WLuL_oHiwc7k7d8vwW_sen60aOrOoM4B6hTg4pxS5PG3F8EeUdqtPaG0R5QWjM0os-3Nn70X05ldFrw9Cyg5msZIwfl00RmV06S8fIAzpUfPMbd5Do4HH9ktdpj9_yb5N8BNPvjc-YMPnLbzPubNJYs2SQv2_rj249ahBahNC_Uv3_-p2w</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Mamah, Daniel</creator><creator>Wang, Lei</creator><creator>Barch, Deanna</creator><creator>de Erausquin, Gabriel A</creator><creator>Gado, Mokhtar</creator><creator>Csernansky, John G</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20070101</creationdate><title>Structural analysis of the basal ganglia in schizophrenia</title><author>Mamah, Daniel ; Wang, Lei ; Barch, Deanna ; de Erausquin, Gabriel A ; Gado, Mokhtar ; Csernansky, John G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c612t-9e7a1aec1a7411dd044a8cd77fc2445178e18a42c1be6f8b06c8951f340f28b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Basal ganglia</topic><topic>Basal Ganglia - drug effects</topic><topic>Basal Ganglia - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Caudate</topic><topic>Caudate Nucleus - drug effects</topic><topic>Caudate Nucleus - pathology</topic><topic>Delusions - diagnosis</topic><topic>Delusions - drug therapy</topic><topic>Dominance, Cerebral - physiology</topic><topic>Dyskinesia, Drug-Induced - diagnosis</topic><topic>Female</topic><topic>Globus pallidus</topic><topic>Globus Pallidus - drug effects</topic><topic>Globus Pallidus - pathology</topic><topic>High-dimensional brain mapping</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurologic Examination - drug effects</topic><topic>Neuropsychological Tests</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - pathology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Putamen</topic><topic>Putamen - drug effects</topic><topic>Putamen - pathology</topic><topic>Reference Values</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenic Psychology</topic><topic>Shape analysis</topic><topic>Statistics as Topic</topic><topic>Structural neuroimaging</topic><topic>Wechsler Scales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mamah, Daniel</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Barch, Deanna</creatorcontrib><creatorcontrib>de Erausquin, Gabriel A</creatorcontrib><creatorcontrib>Gado, Mokhtar</creatorcontrib><creatorcontrib>Csernansky, John G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mamah, Daniel</au><au>Wang, Lei</au><au>Barch, Deanna</au><au>de Erausquin, Gabriel A</au><au>Gado, Mokhtar</au><au>Csernansky, John G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural analysis of the basal ganglia in schizophrenia</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>89</volume><issue>1</issue><spage>59</spage><epage>71</epage><pages>59-71</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Increases in the total volume of basal ganglia structures have been reported in schizophrenia. However, patterns of basal ganglia shape change, which can reveal localized changes in substructure volumes, have not been investigated. In this study, the total volume and shape of several basal ganglia structures were compared in subjects with and without schizophrenia. T1 -weighted magnetic resonance scans were collected in 54 schizophrenia and 70 comparison subjects. High-dimensional (large-deformation) brain mapping was used to assess the shape and volume of several basal ganglia structures. The relationships of shape and volume measures with psychopathology, cognition and motor function were also assessed. Left and right volumes of the caudate and putamen, as well as the right globus pallidus volume, were significantly increased in subjects with schizophrenia as compared to comparison subjects after total brain volume was included as a covariate. Significant differences in shape accompanied these volume changes in the caudate, putamen and globus pallidus, after their total volumes were included as covariates. There were few significant correlations between volume or shape measures and either cognitive function or clinical symptoms, other than a positive correlation between an attention/vigilance cognitive dimension and the volume of the caudate and putamen, and a negative correlation between nucleus accumbens volume and delusions. In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17071057</pmid><doi>10.1016/j.schres.2006.08.031</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-9964 |
| ispartof | Schizophrenia research, 2007-01, Vol.89 (1), p.59-71 |
| issn | 0920-9964 1573-2509 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1839817 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Adult and adolescent clinical studies Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Basal ganglia Basal Ganglia - drug effects Basal Ganglia - pathology Biological and medical sciences Brain Mapping Caudate Caudate Nucleus - drug effects Caudate Nucleus - pathology Delusions - diagnosis Delusions - drug therapy Dominance, Cerebral - physiology Dyskinesia, Drug-Induced - diagnosis Female Globus pallidus Globus Pallidus - drug effects Globus Pallidus - pathology High-dimensional brain mapping Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging Male Medical sciences Middle Aged Neurologic Examination - drug effects Neuropsychological Tests Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - pathology Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Putamen Putamen - drug effects Putamen - pathology Reference Values Schizophrenia Schizophrenia - diagnosis Schizophrenia - drug therapy Schizophrenic Psychology Shape analysis Statistics as Topic Structural neuroimaging Wechsler Scales |
| title | Structural analysis of the basal ganglia in schizophrenia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T01%3A16%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structural%20analysis%20of%20the%20basal%20ganglia%20in%20schizophrenia&rft.jtitle=Schizophrenia%20research&rft.au=Mamah,%20Daniel&rft.date=2007-01-01&rft.volume=89&rft.issue=1&rft.spage=59&rft.epage=71&rft.pages=59-71&rft.issn=0920-9964&rft.eissn=1573-2509&rft_id=info:doi/10.1016/j.schres.2006.08.031&rft_dat=%3Celsevier_pubme%3E1_s2_0_S0920996406003860%3C/elsevier_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/17071057&rft_els_id=1_s2_0_S0920996406003860&rfr_iscdi=true |