PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress

Puma (p53-upregulated modulator of apoptosis), a proapoptotic BH3-only member of the Bcl-2 protein family, has been implicated in the pathomechanism of several diseases, including cancer, AIDS, and ischemic brain disease. We have recently shown that Puma is required for cardiac cell death upon ische...

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Veröffentlicht in:	Cardiovascular research 2007-01, Vol.73 (1), p.48-56
Hauptverfasser:	NICKSON, Philip, TOTH, Ambms, ERHARDT, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Apoptosis Regulatory Proteins Biological and medical sciences Biomarkers - analysis Blotting, Western - methods Calcium-Transporting ATPases - antagonists & inhibitors Cardiology. Vascular system Caspase 3 - analysis Cell Line Cells, Cultured Cytochromes c - analysis Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Gene Deletion Gene Expression Immunohistochemistry - methods In Situ Nick-End Labeling Medical sciences Mice Mice, Knockout Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Proto-Oncogene Proteins c-bcl-2 Rats Reverse Transcriptase Polymerase Chain Reaction RNA Interference Thapsigargin - pharmacology Transfection Tumor Suppressor Protein p53 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tunicamycin - pharmacology
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