GSK-3 Phosphorylation of the Alzheimer Epitope within Collapsin Response Mediator Proteins Regulates Axon Elongation in Primary Neurons

Elevated glycogen synthase kinase-3 (GSK-3) activity is associated with Alzheimer disease. We have found that collapsin response mediator proteins (CRMP) 2 and 4 are physiological substrates of GSK-3. The amino acids targeted by GSK-3 comprise a hyperphosphorylated epitope first identified in plaque...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (48), p.50176-50180
Hauptverfasser:	Cole, Adam R., Knebel, Axel, Morrice, Nick A., Robertson, Laura A., Irving, Andrew J., Connolly, Chris N., Sutherland, Calum
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - immunology Animals Axons - metabolism Epitopes - immunology Glycogen Synthase Kinase 3 - metabolism Intercellular Signaling Peptides and Proteins Nerve Tissue Proteins - immunology Nerve Tissue Proteins - metabolism Phosphorylation Rats Semaphorin-3A - immunology Semaphorin-3A - metabolism
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