The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport

Alcadeinα (Alcα) is an evolutionarily conserved type I membrane protein expressed in neurons. We show here that Alcα strongly associates with kinesin light chain ( K D ≈4–8 × 10 −9 M) through a novel tryptophan‐ and aspartic acid‐containing sequence. Alcα can induce kinesin‐1 association with vesicl...

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