Experimental quantification of the transmission of Porcine reproductive and respiratory syndrome virus
We conducted an experiment to determine the ability of vaccine against Porcine reproductive and respiratory syndrome virus (PRRSV) to reduce the transmission of PRRSV among pigs. At the end of the experiment, transmission rates did not differ significantly (P = 0.61) between the vaccinated and nonva...
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| Veröffentlicht in: | Canadian journal of veterinary research 2007-04, Vol.71 (2), p.157-160 |
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| container_title | Canadian journal of veterinary research |
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| creator | Mondaca-Fernandez, E Meyns, T Munoz-Zanzi, C Trincado, C Morrison, R.B |
| description | We conducted an experiment to determine the ability of vaccine against Porcine reproductive and respiratory syndrome virus (PRRSV) to reduce the transmission of PRRSV among pigs. At the end of the experiment, transmission rates did not differ significantly (P = 0.61) between the vaccinated and nonvaccinated pigs, the mean R-values being 0.598 (95% confidence interval [CI] 0.136 to 3.218) and 0.264 (95% CI 0.008 to 2.266), respectively. The unusually low rate of PRRSV transmission in both groups may not have provided a sufficient challenge to detect a vaccine effect. Several factors could affect the rate of PRRSV transmission: isolate virulence, inoculation dose, inoculation route, number of passages of the challenge virus in cell culture, and population size. Of these, isolate virulence appears to be the most important factor associated with the low transmissibility observed in this study. More studies comparing rates of transmission between PRRSV isolates with diverse levels of virulence are needed to better understand this association. |
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At the end of the experiment, transmission rates did not differ significantly (P = 0.61) between the vaccinated and nonvaccinated pigs, the mean R-values being 0.598 (95% confidence interval [CI] 0.136 to 3.218) and 0.264 (95% CI 0.008 to 2.266), respectively. The unusually low rate of PRRSV transmission in both groups may not have provided a sufficient challenge to detect a vaccine effect. Several factors could affect the rate of PRRSV transmission: isolate virulence, inoculation dose, inoculation route, number of passages of the challenge virus in cell culture, and population size. Of these, isolate virulence appears to be the most important factor associated with the low transmissibility observed in this study. More studies comparing rates of transmission between PRRSV isolates with diverse levels of virulence are needed to better understand this association.</description><identifier>ISSN: 0830-9000</identifier><identifier>PMID: 17479780</identifier><language>eng</language><publisher>Canada: Canadian Veterinary Medical Association</publisher><subject>Animals ; disease transmission ; Dose-Response Relationship, Immunologic ; piglets ; Population Density ; Porcine Reproductive and Respiratory Syndrome - prevention & control ; Porcine Reproductive and Respiratory Syndrome - transmission ; Porcine Reproductive and Respiratory Syndrome - virology ; Porcine reproductive and respiratory syndrome virus ; Porcine respiratory and reproductive syndrome virus - pathogenicity ; Random Allocation ; Short Communication ; Species Specificity ; Swine ; Time Factors ; vaccines ; Viral Vaccines - administration & dosage ; Viral Vaccines - immunology ; Virulence</subject><ispartof>Canadian journal of veterinary research, 2007-04, Vol.71 (2), p.157-160</ispartof><rights>Copyright and/or publishing rights held by the Canadian Veterinary Medical Association 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829187/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829187/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17479780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mondaca-Fernandez, E</creatorcontrib><creatorcontrib>Meyns, T</creatorcontrib><creatorcontrib>Munoz-Zanzi, C</creatorcontrib><creatorcontrib>Trincado, C</creatorcontrib><creatorcontrib>Morrison, R.B</creatorcontrib><title>Experimental quantification of the transmission of Porcine reproductive and respiratory syndrome virus</title><title>Canadian journal of veterinary research</title><addtitle>Can J Vet Res</addtitle><description>We conducted an experiment to determine the ability of vaccine against Porcine reproductive and respiratory syndrome virus (PRRSV) to reduce the transmission of PRRSV among pigs. At the end of the experiment, transmission rates did not differ significantly (P = 0.61) between the vaccinated and nonvaccinated pigs, the mean R-values being 0.598 (95% confidence interval [CI] 0.136 to 3.218) and 0.264 (95% CI 0.008 to 2.266), respectively. The unusually low rate of PRRSV transmission in both groups may not have provided a sufficient challenge to detect a vaccine effect. Several factors could affect the rate of PRRSV transmission: isolate virulence, inoculation dose, inoculation route, number of passages of the challenge virus in cell culture, and population size. Of these, isolate virulence appears to be the most important factor associated with the low transmissibility observed in this study. More studies comparing rates of transmission between PRRSV isolates with diverse levels of virulence are needed to better understand this association.</description><subject>Animals</subject><subject>disease transmission</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>piglets</subject><subject>Population Density</subject><subject>Porcine Reproductive and Respiratory Syndrome - prevention & control</subject><subject>Porcine Reproductive and Respiratory Syndrome - transmission</subject><subject>Porcine Reproductive and Respiratory Syndrome - virology</subject><subject>Porcine reproductive and respiratory syndrome virus</subject><subject>Porcine respiratory and reproductive syndrome virus - pathogenicity</subject><subject>Random Allocation</subject><subject>Short Communication</subject><subject>Species Specificity</subject><subject>Swine</subject><subject>Time Factors</subject><subject>vaccines</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - immunology</subject><subject>Virulence</subject><issn>0830-9000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOwzAQRbMA0fL4BciKXaSxk8bJBglV5SFVAgm6tiaO3Roldmo7Ff17jFoQLEYjzVzdO2dOkilUOWQ1AEySc-8_ACgraX6WTAgrWM0qmCZq8TlIp3tpAnbpdkQTtNICg7YmtSoNG5kGh8b32vvj7NU6oY1MnRycbUcR9E6maNo48IN2GKzbp35vWmd7me60G_1lcqqw8_Lq2C-S1cPiff6ULV8en-f3y0zRqgoZUklFXQJtYNYUFEryXUJKYGrWENayvIaKIeaiQgagBNJZXhSCCNE2pcovkruD7zA2vWxFxHLY8SESottzi5r_3xi94Wu746SiNalYNLg9Gji7HaUPPIIL2XVopB09Z1CUQBiJwuu_Sb8RP6-NgpuDQKHluHba89UbBZJDJGAQ7_4Cp_WBog</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Mondaca-Fernandez, E</creator><creator>Meyns, T</creator><creator>Munoz-Zanzi, C</creator><creator>Trincado, C</creator><creator>Morrison, R.B</creator><general>Canadian Veterinary Medical Association</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070401</creationdate><title>Experimental quantification of the transmission of Porcine reproductive and respiratory syndrome virus</title><author>Mondaca-Fernandez, E ; Meyns, T ; Munoz-Zanzi, C ; Trincado, C ; Morrison, R.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f288t-a2e2c9602b05b420612061cee07f5b17d739087aa3c8a700fca25344c1ccdb6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>disease transmission</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>piglets</topic><topic>Population Density</topic><topic>Porcine Reproductive and Respiratory Syndrome - prevention & control</topic><topic>Porcine Reproductive and Respiratory Syndrome - transmission</topic><topic>Porcine Reproductive and Respiratory Syndrome - virology</topic><topic>Porcine reproductive and respiratory syndrome virus</topic><topic>Porcine respiratory and reproductive syndrome virus - pathogenicity</topic><topic>Random Allocation</topic><topic>Short Communication</topic><topic>Species Specificity</topic><topic>Swine</topic><topic>Time Factors</topic><topic>vaccines</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viral Vaccines - immunology</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mondaca-Fernandez, E</creatorcontrib><creatorcontrib>Meyns, T</creatorcontrib><creatorcontrib>Munoz-Zanzi, C</creatorcontrib><creatorcontrib>Trincado, C</creatorcontrib><creatorcontrib>Morrison, R.B</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mondaca-Fernandez, E</au><au>Meyns, T</au><au>Munoz-Zanzi, C</au><au>Trincado, C</au><au>Morrison, R.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental quantification of the transmission of Porcine reproductive and respiratory syndrome virus</atitle><jtitle>Canadian journal of veterinary research</jtitle><addtitle>Can J Vet Res</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>71</volume><issue>2</issue><spage>157</spage><epage>160</epage><pages>157-160</pages><issn>0830-9000</issn><abstract>We conducted an experiment to determine the ability of vaccine against Porcine reproductive and respiratory syndrome virus (PRRSV) to reduce the transmission of PRRSV among pigs. At the end of the experiment, transmission rates did not differ significantly (P = 0.61) between the vaccinated and nonvaccinated pigs, the mean R-values being 0.598 (95% confidence interval [CI] 0.136 to 3.218) and 0.264 (95% CI 0.008 to 2.266), respectively. The unusually low rate of PRRSV transmission in both groups may not have provided a sufficient challenge to detect a vaccine effect. Several factors could affect the rate of PRRSV transmission: isolate virulence, inoculation dose, inoculation route, number of passages of the challenge virus in cell culture, and population size. Of these, isolate virulence appears to be the most important factor associated with the low transmissibility observed in this study. More studies comparing rates of transmission between PRRSV isolates with diverse levels of virulence are needed to better understand this association.</abstract><cop>Canada</cop><pub>Canadian Veterinary Medical Association</pub><pmid>17479780</pmid><tpages>4</tpages></addata></record> |
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| subjects | Animals disease transmission Dose-Response Relationship, Immunologic piglets Population Density Porcine Reproductive and Respiratory Syndrome - prevention & control Porcine Reproductive and Respiratory Syndrome - transmission Porcine Reproductive and Respiratory Syndrome - virology Porcine reproductive and respiratory syndrome virus Porcine respiratory and reproductive syndrome virus - pathogenicity Random Allocation Short Communication Species Specificity Swine Time Factors vaccines Viral Vaccines - administration & dosage Viral Vaccines - immunology Virulence |
| title | Experimental quantification of the transmission of Porcine reproductive and respiratory syndrome virus |
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