Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification

BACKGROUND:Historic reports on the treatment of pernicious anemia with folic acid suggest that high-level folic acid fortification delays the diagnosis of or exacerbates the effects of vitamin B-12 deficiency, which affects many seniors. This idea is controversial, however, because observational dat...

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Veröffentlicht in:	The American journal of clinical nutrition 2007, Vol.85 (1), p.193-200
Hauptverfasser:	Morris, Martha Savaria, Jacques, Paul F, Rosenberg, Irwin H, Selhub, Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging - blood Americans anemia (disease) Anemia - blood Anemia - epidemiology Anemia - prevention & control Anemia, Macrocytic - blood Anemia, Macrocytic - epidemiology Anemia, Macrocytic - prevention & control Biological and medical sciences cognition Cognition Disorders - blood Cognition Disorders - epidemiology Cognition Disorders - prevention & control Confidence Intervals Creatinine - blood elderly elderly nutrition Feeding. Feeding behavior Female folic acid Folic Acid - administration & dosage Folic Acid - blood Folic Acid - metabolism food fortification Food, Fortified Fundamental and applied biological sciences. Psychology Humans macrocytosis Male men Nutrition Surveys Nutritional Status Odds Ratio Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B 12 - blood Vitamin B 12 Deficiency - complications Vitamin B 12 Deficiency - diagnosis vitamin B12 vitamin deficiencies women
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