Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study
We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each...
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| Veröffentlicht in: | Neuro-oncology (Charlottesville, Va.) Va.), 2007-01, Vol.9 (1), p.75-77 |
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| container_title | Neuro-oncology (Charlottesville, Va.) |
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| creator | Rojas-Marcos, Iñigo Graus, Francesc Sanz, Gema Robledo, Arturo Diaz-Espejo, Carlos |
| description | We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each hippocampus. Ma2 antibodies were found in the patient's serum, and fiberbronchoscopy disclosed a lung carcinoma. After three months of steroid treatment, the results of the patient's neurological exam became normal. We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer. |
| doi_str_mv | 10.1215/15228517-2006-013 |
| format | Article |
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We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer.</description><subject>Aged</subject><subject>Antigens, Neoplasm - immunology</subject><subject>Antigens, Neoplasm - metabolism</subject><subject>Case Study</subject><subject>Disorders of Excessive Somnolence - diagnosis</subject><subject>Encephalitis - diagnosis</subject><subject>Encephalitis - immunology</subject><subject>Encephalitis - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Nerve Tissue Proteins - immunology</subject><subject>Nerve Tissue Proteins - metabolism</subject><issn>1522-8517</issn><issn>1523-5866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUUtLxDAQDqL4_gFepCdv0UyySVMPgiy-QBFBz2GaZjXSNrXTFfbf29X1dZph5nsM8zF2AOIYJOgT0FJaDTmXQhguQK2x7XGmuLbGrH_2ki8BW2yH6FWIkWRgk21BLsCawmyzh-tFF3pKTRsxQ8q6PlBoh9g-Z7RouiE1WZplOE74HUqORMlHHEKVhdaH7gXrOEQ6zTxSyGiYV4s9tjHDmsL-qu6yp8uLx-k1v72_upme33KvinzghTI4sSBEqStZiFxroYtQel1aK2VpJgolYqhmIngryomtSqW1L6wBLABQ7bKzL91uXjah8uPVPdau62OD_cIljO7_po0v7jm9O7By6TsKHK0E-vQ2DzS4JpIPdY1tSHNyxqocQOcjEL6Avk9EfZj9mIBwyyDcdxBuGYQbgxg5h3-v-2WsPq8-ABIWhKQ</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Rojas-Marcos, Iñigo</creator><creator>Graus, Francesc</creator><creator>Sanz, Gema</creator><creator>Robledo, Arturo</creator><creator>Diaz-Espejo, Carlos</creator><general>Duke University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200701</creationdate><title>Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study</title><author>Rojas-Marcos, Iñigo ; Graus, Francesc ; Sanz, Gema ; Robledo, Arturo ; Diaz-Espejo, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-936a48100b5d290755059ebc5b8822b643a2aaedf0ec80b48db355c9861a911a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Antigens, Neoplasm - metabolism</topic><topic>Case Study</topic><topic>Disorders of Excessive Somnolence - diagnosis</topic><topic>Encephalitis - diagnosis</topic><topic>Encephalitis - immunology</topic><topic>Encephalitis - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Nerve Tissue Proteins - immunology</topic><topic>Nerve Tissue Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rojas-Marcos, Iñigo</creatorcontrib><creatorcontrib>Graus, Francesc</creatorcontrib><creatorcontrib>Sanz, Gema</creatorcontrib><creatorcontrib>Robledo, Arturo</creatorcontrib><creatorcontrib>Diaz-Espejo, Carlos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rojas-Marcos, Iñigo</au><au>Graus, Francesc</au><au>Sanz, Gema</au><au>Robledo, Arturo</au><au>Diaz-Espejo, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><addtitle>Neuro Oncol</addtitle><date>2007-01</date><risdate>2007</risdate><volume>9</volume><issue>1</issue><spage>75</spage><epage>77</epage><pages>75-77</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each hippocampus. Ma2 antibodies were found in the patient's serum, and fiberbronchoscopy disclosed a lung carcinoma. After three months of steroid treatment, the results of the patient's neurological exam became normal. We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer.</abstract><cop>England</cop><pub>Duke University Press</pub><pmid>17018696</pmid><doi>10.1215/15228517-2006-013</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1522-8517 |
| ispartof | Neuro-oncology (Charlottesville, Va.), 2007-01, Vol.9 (1), p.75-77 |
| issn | 1522-8517 1523-5866 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aged Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Case Study Disorders of Excessive Somnolence - diagnosis Encephalitis - diagnosis Encephalitis - immunology Encephalitis - therapy Humans Male Nerve Tissue Proteins - immunology Nerve Tissue Proteins - metabolism |
| title | Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study |
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