No Gene Is an Island: The Flip-Flop Phenomenon

An increasing number of publications are replicating a previously reported disease-marker association but with the risk allele reversed from the previous report. Do such “flip-flop” associations confirm or refute the previous association findings? We hypothesized that these associations may indeed b...

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Veröffentlicht in:	American journal of human genetics 2007-03, Vol.80 (3), p.531-538
Hauptverfasser:	Lin, Ping-I, Vance, Jeffery M., Pericak-Vance, Margaret A., Martin, Eden R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Computer Simulation Fundamental and applied biological sciences. Psychology Gene Frequency General aspects. Genetic counseling Genes Genes - physiology Genetic Linkage Genetic Markers Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Humans Hypotheses Linkage Disequilibrium Medical genetics Medical sciences Models, Genetic Molecular and cellular biology Penetrance Polymorphism, Genetic Probability
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