DMY gene induces male development in genetically female (XX) medaka fish
Although the sex-determining gene SRY/Sry has been identified in mammals, homologues and genes that have a similar function have yet to be identified in nonmammalian vertebrates. Recently, DMY (the DM-domain gene on the Y chromosome) was cloned from the sex-determining region on the Y chromosome of...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2007-03, Vol.104 (10), p.3865-3870 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Matsuda, Masaru Shinomiya, Ai Kinoshita, Masato Suzuki, Aya Kobayashi, Tohru Paul-Prasanth, Bindhu Lau, En-lieng Hamaguchi, Satoshi Sakaizumi, Mitsuru Nagahama, Yoshitaka |
| description | Although the sex-determining gene SRY/Sry has been identified in mammals, homologues and genes that have a similar function have yet to be identified in nonmammalian vertebrates. Recently, DMY (the DM-domain gene on the Y chromosome) was cloned from the sex-determining region on the Y chromosome of the teleost fish medaka (Oryzias latipes). DMY has been shown to be required for the normal development of male individuals. In this study, we show that a 117-kb genomic DNA fragment that carries DMY is able to induce testis differentiation and subsequent male development in XX (genetically female) medaka. In addition, overexpression of DMY cDNA under the control of the CMV promoter also caused XX sex reversal. These results demonstrate that DMY is sufficient for male development in medaka and suggest that the functional difference between the X and Y chromosomes in medaka is a single gene. Our data indicate that DMY is an additional sex-determining gene in vertebrates. |
| doi_str_mv | 10.1073/pnas.0611707104 |
| format | Article |
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Recently, DMY (the DM-domain gene on the Y chromosome) was cloned from the sex-determining region on the Y chromosome of the teleost fish medaka (Oryzias latipes). DMY has been shown to be required for the normal development of male individuals. In this study, we show that a 117-kb genomic DNA fragment that carries DMY is able to induce testis differentiation and subsequent male development in XX (genetically female) medaka. In addition, overexpression of DMY cDNA under the control of the CMV promoter also caused XX sex reversal. These results demonstrate that DMY is sufficient for male development in medaka and suggest that the functional difference between the X and Y chromosomes in medaka is a single gene. Our data indicate that DMY is an additional sex-determining gene in vertebrates.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0611707104</identifier><identifier>PMID: 17360444</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animal reproduction ; Animals ; Animals, Genetically Modified ; Base Sequence ; Biological Sciences ; Chromosomes ; Cloning ; Cytomegalovirus ; Deoxyribonucleic acid ; DNA ; DNA, Complementary - metabolism ; Embryos ; Female ; Fish ; Freshwater ; Genes ; Genes, sry ; Genomics ; Germ cells ; Gonads ; Male ; Models, Genetic ; Molecular Sequence Data ; Oryzias - genetics ; Oryzias latipes ; Phenotype ; Promoter Regions, Genetic ; Sex chromosomes ; Sex Determination Processes ; Sex Differentiation ; Somatic cells ; sry genes ; Teleostei ; Transgenic animals ; X Chromosome</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2007-03, Vol.104 (10), p.3865-3870</ispartof><rights>Copyright 2007 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Mar 6, 2007</rights><rights>2007 by The National Academy of Sciences of the USA 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-59c69a0c0b77a2c1dc6536ebc782cbc944cb813edd13b19bcc89882f1412f9ff3</citedby><cites>FETCH-LOGICAL-c552t-59c69a0c0b77a2c1dc6536ebc782cbc944cb813edd13b19bcc89882f1412f9ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/104/10.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25426748$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25426748$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17360444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuda, Masaru</creatorcontrib><creatorcontrib>Shinomiya, Ai</creatorcontrib><creatorcontrib>Kinoshita, Masato</creatorcontrib><creatorcontrib>Suzuki, Aya</creatorcontrib><creatorcontrib>Kobayashi, Tohru</creatorcontrib><creatorcontrib>Paul-Prasanth, Bindhu</creatorcontrib><creatorcontrib>Lau, En-lieng</creatorcontrib><creatorcontrib>Hamaguchi, Satoshi</creatorcontrib><creatorcontrib>Sakaizumi, Mitsuru</creatorcontrib><creatorcontrib>Nagahama, Yoshitaka</creatorcontrib><title>DMY gene induces male development in genetically female (XX) medaka fish</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Although the sex-determining gene SRY/Sry has been identified in mammals, homologues and genes that have a similar function have yet to be identified in nonmammalian vertebrates. Recently, DMY (the DM-domain gene on the Y chromosome) was cloned from the sex-determining region on the Y chromosome of the teleost fish medaka (Oryzias latipes). DMY has been shown to be required for the normal development of male individuals. In this study, we show that a 117-kb genomic DNA fragment that carries DMY is able to induce testis differentiation and subsequent male development in XX (genetically female) medaka. In addition, overexpression of DMY cDNA under the control of the CMV promoter also caused XX sex reversal. These results demonstrate that DMY is sufficient for male development in medaka and suggest that the functional difference between the X and Y chromosomes in medaka is a single gene. Our data indicate that DMY is an additional sex-determining gene in vertebrates.</description><subject>Animal reproduction</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Base Sequence</subject><subject>Biological Sciences</subject><subject>Chromosomes</subject><subject>Cloning</subject><subject>Cytomegalovirus</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Complementary - metabolism</subject><subject>Embryos</subject><subject>Female</subject><subject>Fish</subject><subject>Freshwater</subject><subject>Genes</subject><subject>Genes, sry</subject><subject>Genomics</subject><subject>Germ cells</subject><subject>Gonads</subject><subject>Male</subject><subject>Models, Genetic</subject><subject>Molecular Sequence Data</subject><subject>Oryzias - genetics</subject><subject>Oryzias latipes</subject><subject>Phenotype</subject><subject>Promoter Regions, Genetic</subject><subject>Sex chromosomes</subject><subject>Sex Determination Processes</subject><subject>Sex Differentiation</subject><subject>Somatic cells</subject><subject>sry genes</subject><subject>Teleostei</subject><subject>Transgenic animals</subject><subject>X Chromosome</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0b1v1DAYB2ALgehRmJmAiAGVIe3rb3tBQi1QpCIGqFQmy3Hsaw4nucZJ1f73OL1TDxhg8uDHP78fCD3HcIhB0qN1Z9MhCIwlSAzsAVpg0LgUTMNDtAAgslSMsD30JKUVAGiu4DHaw5IKYIwt0OnJlx_F0ne-aLp6cj4VrY2-qP21j_269d2YL-7A2Dgb420R_J04uLh4W7S-tj9tEZp0-RQ9CjYm_2x77qPzjx--H5-WZ18_fT5-f1Y6zslYcu2EtuCgktISh2snOBW-clIRVznNmKsUpr6uMa2wrpxTWikSMMMk6BDoPnq3yV1PVf7e5QoHG816aFo73JreNubPm665NMv-2mBFQEieA95sA4b-avJpNG2TnI_Rdr6fkpFA1DzR_0KsBaZKQ4av_4Krfhq6PAVDAFMstaYZHW2QG_qUBh_uS8Zg5l2aeZdmt8v84uXvne78dnkZHGzB_HIXx-ZIqgQ3YYpx9Ddjpq_-TbN4sRGrNPbDPSGcESGZ2iUE2xu7HJpkzr_N7QFIzkFK-gv3R8S7</recordid><startdate>20070306</startdate><enddate>20070306</enddate><creator>Matsuda, Masaru</creator><creator>Shinomiya, Ai</creator><creator>Kinoshita, Masato</creator><creator>Suzuki, Aya</creator><creator>Kobayashi, Tohru</creator><creator>Paul-Prasanth, Bindhu</creator><creator>Lau, En-lieng</creator><creator>Hamaguchi, Satoshi</creator><creator>Sakaizumi, Mitsuru</creator><creator>Nagahama, Yoshitaka</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070306</creationdate><title>DMY gene induces male development in genetically female (XX) medaka fish</title><author>Matsuda, Masaru ; 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Recently, DMY (the DM-domain gene on the Y chromosome) was cloned from the sex-determining region on the Y chromosome of the teleost fish medaka (Oryzias latipes). DMY has been shown to be required for the normal development of male individuals. In this study, we show that a 117-kb genomic DNA fragment that carries DMY is able to induce testis differentiation and subsequent male development in XX (genetically female) medaka. In addition, overexpression of DMY cDNA under the control of the CMV promoter also caused XX sex reversal. These results demonstrate that DMY is sufficient for male development in medaka and suggest that the functional difference between the X and Y chromosomes in medaka is a single gene. Our data indicate that DMY is an additional sex-determining gene in vertebrates.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>17360444</pmid><doi>10.1073/pnas.0611707104</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal reproduction Animals Animals, Genetically Modified Base Sequence Biological Sciences Chromosomes Cloning Cytomegalovirus Deoxyribonucleic acid DNA DNA, Complementary - metabolism Embryos Female Fish Freshwater Genes Genes, sry Genomics Germ cells Gonads Male Models, Genetic Molecular Sequence Data Oryzias - genetics Oryzias latipes Phenotype Promoter Regions, Genetic Sex chromosomes Sex Determination Processes Sex Differentiation Somatic cells sry genes Teleostei Transgenic animals X Chromosome |
| title | DMY gene induces male development in genetically female (XX) medaka fish |
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