Activation of the cGMP/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves

In the present study we used a combination of patch clamping and fast confocal Ca 2+ imaging to examine the effects of activators of the nitric oxide (NO)/cGMP pathway on pacemaker activity in freshly dispersed ICC from the rabbit urethra, using the amphotericin B perforated patch configuration of t...

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Veröffentlicht in:	The Journal of physiology 2006-07, Vol.574 (1), p.167-181
Hauptverfasser:	Sergeant, G. P., Johnston, Louise, McHale, N. G., Thornbury, K. D., Hollywood, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Biological Clocks - physiology Calcium - metabolism Calcium Signaling - physiology Cells, Cultured Cellular Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - metabolism Female Male Neural Inhibition - physiology Nitric Oxide - metabolism Rabbits Signal Transduction - physiology Urethra - physiology
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