Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation

Long stretches of glutamine (Q) residues are found in many cellular proteins. Expansion of these polyglutamine (polyQ) sequences is the underlying cause of several neurodegenerative diseases (e.g. Huntington's disease). Eukaryotic proteasomes have been found to digest polyQ sequences in protein...

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Veröffentlicht in:	The EMBO journal 2007-03, Vol.26 (5), p.1385-1396
Hauptverfasser:	Bhutani, N, Venkatraman, P, Goldberg, A L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopeptidases - genetics Aminopeptidases - metabolism Biodegradation cytosol alanyl aminopeptidase Dipeptidyl-Peptidases and Tripeptidyl-Peptidases EMBO24 EMBO31 Endopeptidases - genetics Endopeptidases - metabolism Enzymes Fluorescence glutamine expansion diseases HeLa Cells Humans Immunology Leucyl Aminopeptidase - metabolism Microbiology Models, Biological Molecular biology Neurosciences oligopeptidase Peptide Fragments - chemistry Peptide Fragments - metabolism Peptide Hydrolases - metabolism Peptides Peptides - chemistry Peptides - metabolism polyQ proteins proteasome Proteasome Endopeptidase Complex - metabolism Proteins Residues RNA, Small Interfering - genetics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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