Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast

DNA replication of eukaryotic chromosomes initiates at a number of discrete loci, called replication origins. Distribution and regulation of origins are important for complete duplication of the genome. Here, we determined locations of Orc1 and Mcm6, components of pre‐replicative complex (pre‐RC), o...

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Veröffentlicht in:	The EMBO journal 2007-03, Vol.26 (5), p.1327-1339
Hauptverfasser:	Hayashi, Makoto, Katou, Yuki, Itoh, Takehiko, Tazumi, Mitsutoshi, Yamada, Yoshiki, Takahashi, Tatsuro, Nakagawa, Takuro, Shirahige, Katsuhiko, Masukata, Hisao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell cycle Cell Cycle - genetics Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism centromere Centromere - metabolism Checkpoint Kinase 2 Chromosomes Chromosomes, Fungal Deoxyribonucleic acid Dideoxynucleosides - metabolism DNA DNA microarray DNA Replication - drug effects DNA Replication - genetics DNA, Intergenic - genetics Electrophoresis, Gel, Two-Dimensional EMBO06 EMBO43 fission yeast Genome, Fungal Genomics Heterochromatin - metabolism Hydroxyurea - pharmacology Inactivation Minichromosome Maintenance Complex Component 6 Molecular biology Oligonucleotide Array Sequence Analysis Origin Recognition Complex - genetics Origin Recognition Complex - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism replication origin Replication Origin - genetics Schizosaccharomyces - drug effects Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism subtelomere Yeast Yeasts
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