Diffusion tensor imaging in children and adolescents: Reproducibility, hemispheric, and age-related differences
We evaluated intra-rater, inter-rater, and between-scan reproducibility, hemispheric differences, and the effect of age on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in healthy children (age range 5.5–19.1 years) examined with a clinical diffusion tensor imaging (DTI) protoc...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2007-01, Vol.34 (2), p.733-742 |
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| creator | Bonekamp, David Nagae, Lidia M. Degaonkar, Mahaveer Matson, Melissa Abdalla, Wael M.A. Barker, Peter B. Mori, Susumu Horská, Alena |
| description | We evaluated intra-rater, inter-rater, and between-scan reproducibility, hemispheric differences, and the effect of age on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in healthy children (age range 5.5–19.1 years) examined with a clinical diffusion tensor imaging (DTI) protocol at 1.5 T, using a region of interest (ROI) methodology. Measures of reliability and precision were assessed in six ROIs using two different ROI shapes (polygonal and ellipsoidal).
Results: Highly reproducible values of ADC and FA were obtained with the polygonal method on intra-rater (coefficients of variation ≤
2.7%) and inter-rater (coefficients of variation ≤
4.8%) reproducibility. For between-scan reproducibility, the coefficients of variation were ≤
5.0%. Mean asymmetry indices were in the range from −
4% to 9% for FA and from −
6% to 3% for ADC. ADC showed significant negative correlation with age in 13 of 15 examined fiber tracts and FA increased significantly in three fiber tracts. Our results show that the evaluated DTI protocol is suitable for clinical application in pediatric population. |
| doi_str_mv | 10.1016/j.neuroimage.2006.09.020 |
| format | Article |
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Results: Highly reproducible values of ADC and FA were obtained with the polygonal method on intra-rater (coefficients of variation ≤
2.7%) and inter-rater (coefficients of variation ≤
4.8%) reproducibility. For between-scan reproducibility, the coefficients of variation were ≤
5.0%. Mean asymmetry indices were in the range from −
4% to 9% for FA and from −
6% to 3% for ADC. ADC showed significant negative correlation with age in 13 of 15 examined fiber tracts and FA increased significantly in three fiber tracts. Our results show that the evaluated DTI protocol is suitable for clinical application in pediatric population.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2006.09.020</identifier><identifier>PMID: 17092743</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Anisotropy ; Apparent diffusion coefficient ; Brain ; Brain - anatomy & histology ; Brain maturation ; Child ; Child, Preschool ; Children ; Confidence intervals ; Diffusion ; Diffusion Magnetic Resonance Imaging ; Diffusion tensor imaging ; Female ; Fractional anisotropy ; Hemispheric differences ; Humans ; Image Processing, Computer-Assisted ; Male ; Methods ; NMR ; Nuclear magnetic resonance ; Older people ; Reproducibility ; Reproducibility of Results ; Studies ; Teenagers</subject><ispartof>NeuroImage (Orlando, Fla.), 2007-01, Vol.34 (2), p.733-742</ispartof><rights>2006 Elsevier Inc.</rights><rights>Copyright Elsevier Limited Jan 15, 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-6e8478c3175de26772b3aebbc3283156d4b52084e25f7968669c8f60e19e23293</citedby><cites>FETCH-LOGICAL-c602t-6e8478c3175de26772b3aebbc3283156d4b52084e25f7968669c8f60e19e23293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1053811906009621$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17092743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonekamp, David</creatorcontrib><creatorcontrib>Nagae, Lidia M.</creatorcontrib><creatorcontrib>Degaonkar, Mahaveer</creatorcontrib><creatorcontrib>Matson, Melissa</creatorcontrib><creatorcontrib>Abdalla, Wael M.A.</creatorcontrib><creatorcontrib>Barker, Peter B.</creatorcontrib><creatorcontrib>Mori, Susumu</creatorcontrib><creatorcontrib>Horská, Alena</creatorcontrib><title>Diffusion tensor imaging in children and adolescents: Reproducibility, hemispheric, and age-related differences</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>We evaluated intra-rater, inter-rater, and between-scan reproducibility, hemispheric differences, and the effect of age on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in healthy children (age range 5.5–19.1 years) examined with a clinical diffusion tensor imaging (DTI) protocol at 1.5 T, using a region of interest (ROI) methodology. Measures of reliability and precision were assessed in six ROIs using two different ROI shapes (polygonal and ellipsoidal).
Results: Highly reproducible values of ADC and FA were obtained with the polygonal method on intra-rater (coefficients of variation ≤
2.7%) and inter-rater (coefficients of variation ≤
4.8%) reproducibility. For between-scan reproducibility, the coefficients of variation were ≤
5.0%. Mean asymmetry indices were in the range from −
4% to 9% for FA and from −
6% to 3% for ADC. ADC showed significant negative correlation with age in 13 of 15 examined fiber tracts and FA increased significantly in three fiber tracts. Our results show that the evaluated DTI protocol is suitable for clinical application in pediatric population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Anisotropy</subject><subject>Apparent diffusion coefficient</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain maturation</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Confidence intervals</subject><subject>Diffusion</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Diffusion tensor imaging</subject><subject>Female</subject><subject>Fractional anisotropy</subject><subject>Hemispheric differences</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Methods</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Older people</subject><subject>Reproducibility</subject><subject>Reproducibility of Results</subject><subject>Studies</subject><subject>Teenagers</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkV1rFDEUhoNYbF39CxIQvOpMk8xMPrwQaq1WKAii1yGTnNnNMpusyUyh_94Mu7Tam14lkOe8Oec8CGFKakoov9jWAeYU_c6soWaE8JqomjDyAp1RorpKdYK9XO5dU0lK1Sl6nfOWEKJoK1-hUyqIYqJtzlD84odhzj4GPEHIMeEl1Ic19gHbjR9dgoBNcNi4OEK2EKb8Ef-EfYputr73o5_uz_EGdj7vN5C8PT_ga6gSjGYCh135A0qOhfwGnQxmzPD2eK7Q76_Xv65uqtsf375fXd5WlhM2VRxkK6RtqOgcMC4E6xsDfW8bJhvacdf2HSOyBdYNQnHJubJy4ASoAtYw1azQp0Pufu534Ja2kxn1PpXx0r2Oxuv_X4Lf6HW801TSri2rWaEPx4AU_8yQJ10GtDCOJkCcs-ay4aK4eBakquWtYkvi-yfgNs4plC1o2hEuKBdqoeSBsinmnGB46JkSvcjXW_0oXy_yNVG6yC-l7_6d-bHwaLsAnw8AlM3feUg6W79ocT6BnbSL_vlf_gJU8scM</recordid><startdate>20070115</startdate><enddate>20070115</enddate><creator>Bonekamp, David</creator><creator>Nagae, Lidia M.</creator><creator>Degaonkar, Mahaveer</creator><creator>Matson, Melissa</creator><creator>Abdalla, Wael M.A.</creator><creator>Barker, Peter B.</creator><creator>Mori, Susumu</creator><creator>Horská, Alena</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7QO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070115</creationdate><title>Diffusion tensor imaging in children and adolescents: Reproducibility, hemispheric, and age-related differences</title><author>Bonekamp, David ; Nagae, Lidia M. ; Degaonkar, Mahaveer ; Matson, Melissa ; Abdalla, Wael M.A. ; Barker, Peter B. ; Mori, Susumu ; Horská, Alena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-6e8478c3175de26772b3aebbc3283156d4b52084e25f7968669c8f60e19e23293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Anisotropy</topic><topic>Apparent diffusion coefficient</topic><topic>Brain</topic><topic>Brain - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonekamp, David</au><au>Nagae, Lidia M.</au><au>Degaonkar, Mahaveer</au><au>Matson, Melissa</au><au>Abdalla, Wael M.A.</au><au>Barker, Peter B.</au><au>Mori, Susumu</au><au>Horská, Alena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion tensor imaging in children and adolescents: Reproducibility, hemispheric, and age-related differences</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2007-01-15</date><risdate>2007</risdate><volume>34</volume><issue>2</issue><spage>733</spage><epage>742</epage><pages>733-742</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>We evaluated intra-rater, inter-rater, and between-scan reproducibility, hemispheric differences, and the effect of age on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in healthy children (age range 5.5–19.1 years) examined with a clinical diffusion tensor imaging (DTI) protocol at 1.5 T, using a region of interest (ROI) methodology. Measures of reliability and precision were assessed in six ROIs using two different ROI shapes (polygonal and ellipsoidal).
Results: Highly reproducible values of ADC and FA were obtained with the polygonal method on intra-rater (coefficients of variation ≤
2.7%) and inter-rater (coefficients of variation ≤
4.8%) reproducibility. For between-scan reproducibility, the coefficients of variation were ≤
5.0%. Mean asymmetry indices were in the range from −
4% to 9% for FA and from −
6% to 3% for ADC. ADC showed significant negative correlation with age in 13 of 15 examined fiber tracts and FA increased significantly in three fiber tracts. Our results show that the evaluated DTI protocol is suitable for clinical application in pediatric population.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17092743</pmid><doi>10.1016/j.neuroimage.2006.09.020</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-8119 |
| ispartof | NeuroImage (Orlando, Fla.), 2007-01, Vol.34 (2), p.733-742 |
| issn | 1053-8119 1095-9572 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1815474 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Age Factors Anisotropy Apparent diffusion coefficient Brain Brain - anatomy & histology Brain maturation Child Child, Preschool Children Confidence intervals Diffusion Diffusion Magnetic Resonance Imaging Diffusion tensor imaging Female Fractional anisotropy Hemispheric differences Humans Image Processing, Computer-Assisted Male Methods NMR Nuclear magnetic resonance Older people Reproducibility Reproducibility of Results Studies Teenagers |
| title | Diffusion tensor imaging in children and adolescents: Reproducibility, hemispheric, and age-related differences |
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