Resveratrol and curcumin suppress immune response through CD28/CTLA‐4 and CD80 co‐stimulatory pathway
Summary The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and cu...
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| Veröffentlicht in: | Clinical and experimental immunology 2007-01, Vol.147 (1), p.155-163 |
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| creator | Sharma, S. Chopra, K. Kulkarni, S. K. Agrewala, J. N. |
| description | Summary
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down‐regulating the expression of CD28 and CD80 and up‐regulating CTLA‐4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)‐10. |
| doi_str_mv | 10.1111/j.1365-2249.2006.03257.x |
| format | Article |
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The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down‐regulating the expression of CD28 and CD80 and up‐regulating CTLA‐4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)‐10.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/j.1365-2249.2006.03257.x</identifier><identifier>PMID: 17177975</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Antigens, CD - immunology ; Antigens, Differentiation - immunology ; Antineoplastic Agents - pharmacology ; B-Lymphocytes - drug effects ; B7-1 Antigen - immunology ; Basic Immunology ; Biological and medical sciences ; CD28 ; CD28 Antigens - immunology ; CD4-Positive T-Lymphocytes - immunology ; CD40 ; CD40 Antigens - immunology ; CD80 ; Cell Proliferation - drug effects ; Cell Survival ; Cells, Cultured ; Concanavalin A ; CTLA-4 Antigen ; CTLA‐4 ; curcumin ; Curcumin - pharmacology ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; IL‐10 ; Immunoglobulin G - immunology ; Immunopathology ; Lipopolysaccharides ; Lymphocytes - immunology ; Macrophage Activation - drug effects ; Macrophages - drug effects ; Medical sciences ; Mice ; Mice, Inbred BALB C ; resveratrol ; Stilbenes - pharmacology</subject><ispartof>Clinical and experimental immunology, 2007-01, Vol.147 (1), p.155-163</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Jan 2007</rights><rights>2006 British Society for Immunology 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5957-3f7f32e9931fb69bdabdf4f9dc9b61a0546991aa6dd86a490fda89eee59087453</citedby><cites>FETCH-LOGICAL-c5957-3f7f32e9931fb69bdabdf4f9dc9b61a0546991aa6dd86a490fda89eee59087453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810449/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810449/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18488184$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17177975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, S.</creatorcontrib><creatorcontrib>Chopra, K.</creatorcontrib><creatorcontrib>Kulkarni, S. K.</creatorcontrib><creatorcontrib>Agrewala, J. N.</creatorcontrib><title>Resveratrol and curcumin suppress immune response through CD28/CTLA‐4 and CD80 co‐stimulatory pathway</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Summary
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down‐regulating the expression of CD28 and CD80 and up‐regulating CTLA‐4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)‐10.</description><subject>Animals</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, Differentiation - immunology</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>B-Lymphocytes - drug effects</subject><subject>B7-1 Antigen - immunology</subject><subject>Basic Immunology</subject><subject>Biological and medical sciences</subject><subject>CD28</subject><subject>CD28 Antigens - immunology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD40</subject><subject>CD40 Antigens - immunology</subject><subject>CD80</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival</subject><subject>Cells, Cultured</subject><subject>Concanavalin A</subject><subject>CTLA-4 Antigen</subject><subject>CTLA‐4</subject><subject>curcumin</subject><subject>Curcumin - pharmacology</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>IL‐10</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunopathology</subject><subject>Lipopolysaccharides</subject><subject>Lymphocytes - immunology</subject><subject>Macrophage Activation - drug effects</subject><subject>Macrophages - drug effects</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>resveratrol</subject><subject>Stilbenes - pharmacology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxi0EokvhFZCFBLekdpz4zwGkKi1QaSUkVM6W4zhdr5I42HHbvfEIPGOfpE531QInfLBnNL9vNOMPAIhRjtM52eaY0CorilLkBUI0R6SoWH77DKweC8_BCiEkMoFReQRehbBNKaW0eAmOMMOMCVatgP1uwrXxavauh2psoY5ex8GOMMRp8iYEaIchjgameHJjMHDeeBevNrA-K_hJfbk-vfv1u3zQ1mccQe1SHmY7xF7Nzu_gpObNjdq9Bi861Qfz5vAegx-fzy_rr9n625eL-nSd6UpULCMd60hhhCC4a6hoWtW0XdmJVouGYoWqkgqBlaJty6kqBepaxYUxphKIs7Iix-DTvu8Um8G02oyzV72cvB2U30mnrPy7MtqNvHLXEvP0U6VIDT4cGnj3M5owy8EGbfpejcbFICknHBesSOC7f8Cti35My0ksKBeUEJYgvoe0dyF40z1OgpFczJRbuXgmF8_kYqZ8MFPeJunbPzd5Eh7cS8D7A6CCVn3n1ahteOJ4yXm6Evdxz93Y3uz-ewBZn18sEbkH7Ii93Q</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Sharma, S.</creator><creator>Chopra, K.</creator><creator>Kulkarni, S. K.</creator><creator>Agrewala, J. N.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200701</creationdate><title>Resveratrol and curcumin suppress immune response through CD28/CTLA‐4 and CD80 co‐stimulatory pathway</title><author>Sharma, S. ; Chopra, K. ; Kulkarni, S. K. ; Agrewala, J. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5957-3f7f32e9931fb69bdabdf4f9dc9b61a0546991aa6dd86a490fda89eee59087453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, Differentiation - immunology</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>B-Lymphocytes - drug effects</topic><topic>B7-1 Antigen - immunology</topic><topic>Basic Immunology</topic><topic>Biological and medical sciences</topic><topic>CD28</topic><topic>CD28 Antigens - immunology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD40</topic><topic>CD40 Antigens - immunology</topic><topic>CD80</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival</topic><topic>Cells, Cultured</topic><topic>Concanavalin A</topic><topic>CTLA-4 Antigen</topic><topic>CTLA‐4</topic><topic>curcumin</topic><topic>Curcumin - pharmacology</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>IL‐10</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunopathology</topic><topic>Lipopolysaccharides</topic><topic>Lymphocytes - immunology</topic><topic>Macrophage Activation - drug effects</topic><topic>Macrophages - drug effects</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>resveratrol</topic><topic>Stilbenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, S.</creatorcontrib><creatorcontrib>Chopra, K.</creatorcontrib><creatorcontrib>Kulkarni, S. K.</creatorcontrib><creatorcontrib>Agrewala, J. N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, S.</au><au>Chopra, K.</au><au>Kulkarni, S. K.</au><au>Agrewala, J. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol and curcumin suppress immune response through CD28/CTLA‐4 and CD80 co‐stimulatory pathway</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2007-01</date><risdate>2007</risdate><volume>147</volume><issue>1</issue><spage>155</spage><epage>163</epage><pages>155-163</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>Summary
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down‐regulating the expression of CD28 and CD80 and up‐regulating CTLA‐4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)‐10.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17177975</pmid><doi>10.1111/j.1365-2249.2006.03257.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antigens, CD - immunology Antigens, Differentiation - immunology Antineoplastic Agents - pharmacology B-Lymphocytes - drug effects B7-1 Antigen - immunology Basic Immunology Biological and medical sciences CD28 CD28 Antigens - immunology CD4-Positive T-Lymphocytes - immunology CD40 CD40 Antigens - immunology CD80 Cell Proliferation - drug effects Cell Survival Cells, Cultured Concanavalin A CTLA-4 Antigen CTLA‐4 curcumin Curcumin - pharmacology Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology IL‐10 Immunoglobulin G - immunology Immunopathology Lipopolysaccharides Lymphocytes - immunology Macrophage Activation - drug effects Macrophages - drug effects Medical sciences Mice Mice, Inbred BALB C resveratrol Stilbenes - pharmacology |
| title | Resveratrol and curcumin suppress immune response through CD28/CTLA‐4 and CD80 co‐stimulatory pathway |
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