Interferon‐γ independent formation of pulmonary granuloma in mice by injections with trehalose dimycolate (cord factor), lipoarabinomannan and phosphatidylinositol mannosides isolated from Mycobacterium tuberculosis

Summary The mechanisms by which pulmonary granuloma formation is caused by administration of mycobacterial glycolipids such as trehalose dimycolate (TDM), lipoarabinomannan (LAM) and phosphatidylinositol mannosides (PIM) were investigated. When peritoneal and alveolar macrophages were stimulated wit...

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Veröffentlicht in:	Clinical and experimental immunology 2006-04, Vol.144 (1), p.134-141
Hauptverfasser:	Takimoto, H., Maruyama, H., Shimada, K.‐I., Yakabe, R., Yano, I., Kumazawa, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Animal Studies Animals Antigens, Bacterial - immunology Cord Factors - administration & dosage Female Glycolipids - administration & dosage Granuloma - immunology granuloma formation Injections Interferon-gamma - immunology Lipopolysaccharides - administration & dosage Lung Diseases - immunology Macrophages - immunology Macrophages, Alveolar - immunology Macrophages, Peritoneal - immunology Mice Mice, Inbred BALB C mycobacterial glycolipids Mycobacterium tuberculosis Mycobacterium tuberculosis - chemistry Phosphatidylinositols - administration & dosage Toll-Like Receptor 4 - immunology Tumor Necrosis Factor-alpha - immunology
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