Transgenic over‐expression of macrophage migration inhibitory factor renders mice markedly more susceptible to experimental colitis

Summary Enhanced production of macrophage migration inhibitory factor (MIF) is recognized in patients with inflammatory bowel disease (IBD) and mice with experimental colitis; however, the precise molecular function of MIF in colitis is not fully understood. To further investigate this matter, we ex...

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Veröffentlicht in:	Clinical and experimental immunology 2005-05, Vol.140 (2), p.241-248
Hauptverfasser:	Ohkawara, T., Miyashita, K., Nishihira, J., Mitsuyama, K., Takeda, H., Kato, M., Kondo, N., Yamasaki, Y., Sata, M., Yoshiki, T., Sugiyama, T., Asaka, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Studies Animals Colitis - chemically induced Colitis - metabolism Colitis - pathology Colon - metabolism corticosterone Corticosterone - blood Dextran Sulfate dextran sulphate sodium‐induced colitis Disease Susceptibility inflammatory bowel disease macrophage migration inhibitory factor Macrophage Migration-Inhibitory Factors - biosynthesis Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - physiology Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Transgenic neutrophil Neutrophil Infiltration Peroxidase - metabolism RNA, Messenger - genetics Severity of Illness Index
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