Polyreactive antigen‐binding B (PAB+) cells are widely distributed and the PAB+ population consists of both B‐1+ and B‐1– phenotypes
SUMMARY B cells that make polyreactive antibodies (PAB+ cells) express polyreactive Ig receptors on their surface and can bind a variety of different antigens. The present study shows that PAB+ cells are widely distributed, are present in varying numbers in different lymphoid organs and that their p...
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| Veröffentlicht in: | Clinical and experimental immunology 2004-07, Vol.137 (1), p.88-100 |
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| creator | ZHOU, ZHAO‐HUA NOTKINS, A. L. |
| description | SUMMARY
B cells that make polyreactive antibodies (PAB+ cells) express polyreactive Ig receptors on their surface and can bind a variety of different antigens. The present study shows that PAB+ cells are widely distributed, are present in varying numbers in different lymphoid organs and that their phenotype varies depending on the organs from which they are isolated. Up to 10 times more cells in PAB+ enriched populations bind antigens as compared to PAB– populations. Comparison of PAB+ with B‐1+ cells showed that a high percentage of PAB+ cells are B‐1+, but that many PAB+ cells do not express B‐1 cell surface markers and, in fact, are B‐1–. It is concluded that the B cell population consists of PAB+/B‐1+, PAB+/B‐1–, PAB–/B‐1+, and PAB–/B‐1– cells. The presence of PAB+ cells in the thymus points to the possibility that PAB+ cells may carry endogenous host antigens from peripheral tissues to the thymus where they may contribute to immunological tolerance. |
| doi_str_mv | 10.1111/j.1365-2249.2004.02511.x |
| format | Article |
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B cells that make polyreactive antibodies (PAB+ cells) express polyreactive Ig receptors on their surface and can bind a variety of different antigens. The present study shows that PAB+ cells are widely distributed, are present in varying numbers in different lymphoid organs and that their phenotype varies depending on the organs from which they are isolated. Up to 10 times more cells in PAB+ enriched populations bind antigens as compared to PAB– populations. Comparison of PAB+ with B‐1+ cells showed that a high percentage of PAB+ cells are B‐1+, but that many PAB+ cells do not express B‐1 cell surface markers and, in fact, are B‐1–. It is concluded that the B cell population consists of PAB+/B‐1+, PAB+/B‐1–, PAB–/B‐1+, and PAB–/B‐1– cells. The presence of PAB+ cells in the thymus points to the possibility that PAB+ cells may carry endogenous host antigens from peripheral tissues to the thymus where they may contribute to immunological tolerance.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/j.1365-2249.2004.02511.x</identifier><identifier>PMID: 15196248</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Animals ; Antibodies - immunology ; Antigen-Antibody Reactions - immunology ; Antigens - immunology ; Antigens, CD - immunology ; Antigens, Surface - immunology ; B cell receptor ; B-Lymphocyte Subsets - immunology ; B-Lymphocytes - immunology ; Basic Immunology ; Biological and medical sciences ; Cells, Cultured ; Endotoxins - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immune Tolerance - immunology ; Immunity, Innate - immunology ; Immunoglobulin M - immunology ; immunological tolerance ; Immunopathology ; innate immunity ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred Strains ; natural antibodies ; natural immunity ; Phenotype ; Receptors, Antigen, B-Cell - immunology ; Thymus Gland - immunology</subject><ispartof>Clinical and experimental immunology, 2004-07, Vol.137 (1), p.88-100</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jul 2004</rights><rights>2004 Blackwell Publishing Ltd 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5271-73ceb6122238a5c3cda6179e600d3719b7549f868752e6c446817e217029937b3</citedby><cites>FETCH-LOGICAL-c5271-73ceb6122238a5c3cda6179e600d3719b7549f868752e6c446817e217029937b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809069/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809069/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15877756$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15196248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZHOU, ZHAO‐HUA</creatorcontrib><creatorcontrib>NOTKINS, A. L.</creatorcontrib><title>Polyreactive antigen‐binding B (PAB+) cells are widely distributed and the PAB+ population consists of both B‐1+ and B‐1– phenotypes</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>SUMMARY
B cells that make polyreactive antibodies (PAB+ cells) express polyreactive Ig receptors on their surface and can bind a variety of different antigens. The present study shows that PAB+ cells are widely distributed, are present in varying numbers in different lymphoid organs and that their phenotype varies depending on the organs from which they are isolated. Up to 10 times more cells in PAB+ enriched populations bind antigens as compared to PAB– populations. Comparison of PAB+ with B‐1+ cells showed that a high percentage of PAB+ cells are B‐1+, but that many PAB+ cells do not express B‐1 cell surface markers and, in fact, are B‐1–. It is concluded that the B cell population consists of PAB+/B‐1+, PAB+/B‐1–, PAB–/B‐1+, and PAB–/B‐1– cells. The presence of PAB+ cells in the thymus points to the possibility that PAB+ cells may carry endogenous host antigens from peripheral tissues to the thymus where they may contribute to immunological tolerance.</description><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Antigen-Antibody Reactions - immunology</subject><subject>Antigens - immunology</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, Surface - immunology</subject><subject>B cell receptor</subject><subject>B-Lymphocyte Subsets - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Basic Immunology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Endotoxins - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immune Tolerance - immunology</subject><subject>Immunity, Innate - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>immunological tolerance</subject><subject>Immunopathology</subject><subject>innate immunity</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred Strains</subject><subject>natural antibodies</subject><subject>natural immunity</subject><subject>Phenotype</subject><subject>Receptors, Antigen, B-Cell - immunology</subject><subject>Thymus Gland - immunology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhiMEotvCKyALCQSqNthOYscHkLqrApUq0QOcLceZ7HqVtVM7abu3PkAPSLxhnwRnd1UKJ3zxWPPNr_n9JwkiOCXxfFilJGPFlNJcpBTjPMW0ICS9eZJMHhpPkwnGWEwFwflBchjCKj4ZY_R5ckAKIhjNy0lyd-HajQele3MFSNneLMDe3_6sjK2NXaAZendxMjt-jzS0bUDKA7o2NbQbVJvQe1MNPdRxrkb9EtCIos51Q6t64yzSzoaIBeQaVLl-iWZRmhxv-W15f_sLdUuwrt90EF4kzxrVBni5v4-SH59Pv8-_Ts-_fTmbn5xPdUE5mfJMQ8UIpTQrVaEzXStGuACGcZ1xIipe5KIpWckLCkznOSsJB0o4pkJkvMqOkk873W6o1lBrsL1Xrey8WSu_kU4Z-XfHmqVcuCtJSiwwE1Hg7V7Au8sBQi_XJow_pCy4IUhOMc0ZJhF8_Q-4coO30ZyMCZQijxYiVO4g7V0IHpqHTQiWY95yJcdY5RirHPOW27zlTRx99djJn8F9wBF4swdU0KptvLLahEdcyTkvWOQ-7rhr08LmvxeQ89Ozscp-A2gcyIE</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>ZHOU, ZHAO‐HUA</creator><creator>NOTKINS, A. L.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200407</creationdate><title>Polyreactive antigen‐binding B (PAB+) cells are widely distributed and the PAB+ population consists of both B‐1+ and B‐1– phenotypes</title><author>ZHOU, ZHAO‐HUA ; NOTKINS, A. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5271-73ceb6122238a5c3cda6179e600d3719b7549f868752e6c446817e217029937b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antibodies - immunology</topic><topic>Antigen-Antibody Reactions - immunology</topic><topic>Antigens - immunology</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, Surface - immunology</topic><topic>B cell receptor</topic><topic>B-Lymphocyte Subsets - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Basic Immunology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Endotoxins - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immune Tolerance - immunology</topic><topic>Immunity, Innate - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>immunological tolerance</topic><topic>Immunopathology</topic><topic>innate immunity</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred Strains</topic><topic>natural antibodies</topic><topic>natural immunity</topic><topic>Phenotype</topic><topic>Receptors, Antigen, B-Cell - immunology</topic><topic>Thymus Gland - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZHOU, ZHAO‐HUA</creatorcontrib><creatorcontrib>NOTKINS, A. L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZHOU, ZHAO‐HUA</au><au>NOTKINS, A. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyreactive antigen‐binding B (PAB+) cells are widely distributed and the PAB+ population consists of both B‐1+ and B‐1– phenotypes</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2004-07</date><risdate>2004</risdate><volume>137</volume><issue>1</issue><spage>88</spage><epage>100</epage><pages>88-100</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>SUMMARY
B cells that make polyreactive antibodies (PAB+ cells) express polyreactive Ig receptors on their surface and can bind a variety of different antigens. The present study shows that PAB+ cells are widely distributed, are present in varying numbers in different lymphoid organs and that their phenotype varies depending on the organs from which they are isolated. Up to 10 times more cells in PAB+ enriched populations bind antigens as compared to PAB– populations. Comparison of PAB+ with B‐1+ cells showed that a high percentage of PAB+ cells are B‐1+, but that many PAB+ cells do not express B‐1 cell surface markers and, in fact, are B‐1–. It is concluded that the B cell population consists of PAB+/B‐1+, PAB+/B‐1–, PAB–/B‐1+, and PAB–/B‐1– cells. The presence of PAB+ cells in the thymus points to the possibility that PAB+ cells may carry endogenous host antigens from peripheral tissues to the thymus where they may contribute to immunological tolerance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15196248</pmid><doi>10.1111/j.1365-2249.2004.02511.x</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antibodies - immunology Antigen-Antibody Reactions - immunology Antigens - immunology Antigens, CD - immunology Antigens, Surface - immunology B cell receptor B-Lymphocyte Subsets - immunology B-Lymphocytes - immunology Basic Immunology Biological and medical sciences Cells, Cultured Endotoxins - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Immune Tolerance - immunology Immunity, Innate - immunology Immunoglobulin M - immunology immunological tolerance Immunopathology innate immunity Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains natural antibodies natural immunity Phenotype Receptors, Antigen, B-Cell - immunology Thymus Gland - immunology |
| title | Polyreactive antigen‐binding B (PAB+) cells are widely distributed and the PAB+ population consists of both B‐1+ and B‐1– phenotypes |
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