Increase in granzyme B+ lymphocytes and soluble granzyme B in bronchoalveolar lavage of allergen challenged patients with atopic asthma

SUMMARY Asthma has been linked to a chronic, T‐cell‐mediated bronchial inflammation. Because other T‐lymphocyte‐mediated, chronic inflammatory disorders have been associated with elevated granzyme B (grB) expression we tested the hypothesis that atopic asthma might be associated with elevated grB le...

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Veröffentlicht in:	Clinical and experimental immunology 2004-06, Vol.136 (3), p.542-548
Hauptverfasser:	BRATKE, K., BÖTTCHER, B., LEEDER, K., SCHMIDT, S., KÜPPER, M., VIRCHOW, J.C., LUTTMANN, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergens asthma Asthma - immunology B-Lymphocytes - immunology Biological and medical sciences Bronchial Provocation Tests Bronchoalveolar Lavage Fluid - chemistry Chronic obstructive pulmonary disease, asthma Clinical Studies cytotoxic lymphocytes Female granzyme B Granzymes Humans inflammation Interleukin-5 - analysis Male Medical sciences NK cell Pneumology Serine Endopeptidases - analysis
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