IL‐17 enhances the susceptibility of U‐2 OS osteosarcoma cells to NK cell lysis

SUMMARY We investigated the effect of the proinflammatory cytokine interleukin 17 (IL‐17) on the lysis of osteosarcoma cells by human NK cells. NK cells and U‐2 OS, MG‐63, HOS osteosarcoma cell lines express the IL‐17 receptor, the highest amount being found on U‐2 OS. Pre‐incubation of NK cells wit...

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Veröffentlicht in:	Clinical and experimental immunology 2003-09, Vol.133 (3), p.344-349
Hauptverfasser:	HONORATI, M. C., NERI, S., CATTINI, L., FACCHINI, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion molecules Adult Basic Immunology Biological and medical sciences Bone Neoplasms - immunology Bone Neoplasms - metabolism Cytotoxicity Tests, Immunologic Diseases of the osteoarticular system Fibronectins - metabolism Flow Cytometry Humans IL‐17 Integrin alpha2 - metabolism Integrin alpha6 - metabolism Interferon-gamma - therapeutic use Interleukin-17 - therapeutic use Killer Cells, Natural - immunology Medical sciences NK activity osteosarcoma Osteosarcoma - immunology Osteosarcoma - metabolism Receptors, Interleukin - analysis Receptors, Interleukin-17 Recombinant Proteins - analysis Stimulation, Chemical Tumor Cells, Cultured Tumors of striated muscle and skeleton
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